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Entry version 28 (02 Jun 2021)
Sequence version 1 (22 Jul 2008)
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Protein

Cingulin

Gene

CGN

Organism
Sorex araneus (Eurasian common shrew) (European shrew)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.

By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cingulin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CGN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSorex araneus (Eurasian common shrew) (European shrew)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri42254 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaEulipotyphlaSoricidaeSoricinaeSorex

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Tight junction

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003714321 – 1153CingulinAdd BLAST1153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei86PhosphoserineBy similarity1
Modified residuei126PhosphoserineBy similarity1
Modified residuei128PhosphoserineBy similarity1
Modified residuei131PhosphoserineBy similarity1
Modified residuei146PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1
Modified residuei208PhosphoserineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei562N6-acetyllysineBy similarity1
Modified residuei1125PhosphoserineBy similarity1
Modified residuei1126PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
B3EX63

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts with TJP1/ZO1 and SPEF1 (By similarity).

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B3EX63

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 342HeadBy similarityAdd BLAST342
Regioni17 – 37DisorderedSequence analysisAdd BLAST21
Regioni44 – 57Interaction with TJP1/ZO1By similarityAdd BLAST14
Regioni131 – 151DisorderedSequence analysisAdd BLAST21
Regioni177 – 253DisorderedSequence analysisAdd BLAST77
Regioni755 – 796DisorderedSequence analysisAdd BLAST42
Regioni823 – 861DisorderedSequence analysisAdd BLAST39
Regioni1110 – 1131DisorderedSequence analysisAdd BLAST22
Regioni1111 – 1153TailBy similarityAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili343 – 1110Sequence analysisAdd BLAST768

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi38 – 52ZIMAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi191 – 219Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi231 – 253Polar residuesSequence analysisAdd BLAST23
Compositional biasi771 – 796Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi825 – 849Basic and acidic residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Deletion of the TJP1/ZO1 interaction motif (ZIM) decreases but does not abolish colocalization with TJP1/ZO1.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cingulin family.Curated

Keywords - Domaini

Coiled coil

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002928, Myosin_tail

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01576, Myosin_tail_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3EX63-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEPRGPVDH GVQIRFITEP AGDAQMRTGR RPAKDARANT YGVAVRVQGI
60 70 80 90 100
AGQPFVVLNS GEKGSESFGV QIKGAHRQGP PGAPHSDLEL PAEHSRPLAQ
110 120 130 140 150
ENAGTWQGSV SDEELGDPWR GRLLRSQSQA SLLGPAPLGP GHRSTSLLEL
160 170 180 190 200
GPPGLGAGSA IDTAPLSSVD TLIHKFDRHQ GGQARGRTGR RMRALPAEQR
210 220 230 240 250
KRSQSLDSRH LRDPPEDRRS PIPWAPPSRP GSAGSSKQPA PKPIPTSSYS
260 270 280 290 300
RARQTQDWVL QNFEEPRTRA QDPAVLQFKS TPDLLRDQQE AAPPGSVEHV
310 320 330 340 350
KAALYGILRE GSSESDASVR RKVSLVLEQM QPLVMTTGSA KVLAGQGELA
360 370 380 390 400
QKVEELQRKL DEEVKKRQVL EPSRLELEQQ LEEKAEECLR LQELLERQKG
410 420 430 440 450
ETRQSGTELQ NLRLLLDQAG RVRSELETQV MELQDQLKQG PVPAKEGLMK
460 470 480 490 500
DLLETRELLE EVLEGKQRVE EQLRQREREL TALKGALKEE VASRDQEVEH
510 520 530 540 550
VRQQCQRDTE QLRKSIQDAS QDQAALEAER QKMSALVRGL QRELEETSEE
560 570 580 590 600
TGHWQTMFQK NKEELRAAKQ ELLQLRMEKD EMEEELGEKM EALQRELGQA
610 620 630 640 650
RAGAGGSRQV EELRKLQGEA ERVRELEQQN LQLQKKTQQL SQDCAEATKA
660 670 680 690 700
RGARMAAEAE AALLVQRRTA VETTLQETQG ENDEFRRRIL GLEQQLKETR
710 720 730 740 750
GLAEGGEAAE ARLRDKLQRL EVEKQRLEEA LSEAQAEEGS LAAAKRALEA
760 770 780 790 800
RLEEAQRGLS RMGQEQQALS RALEEEGKQR EALRRGKAEL EEQKRLLDRT
810 820 830 840 850
VERLNKELEQ IGEDSKQALH QLQSQLEDYK EKSRREVADA QRQAKEWASE
860 870 880 890 900
AEKSSGGLSR LQDETQRLRQ TLQASQADLD TARLDKELLA QRLQGLEQEA
910 920 930 940 950
EKKRRSQDDR TRQVKSLEEK VSRLEMELDE ERNTVELLTD RINRSRDQVD
960 970 980 990 1000
QLRTELMQER SARQDLECDK ISLERQNKDL KGRLASLEGF QKPSASLSQL
1010 1020 1030 1040 1050
ESQNRELQER LQAEDREKTV LQSTNRKLER RVKELSIQID DERQHVNDQK
1060 1070 1080 1090 1100
DQLSLKVKAL KRQVDEAEEE IERLDGLRKK AQRELEEQHE ANEQLQARIR
1110 1120 1130 1140 1150
ALEKDSWRKA ARSAAESSLQ QEGLSSDEEF DGVYNPNSIA SLLTESGLQT

SSC
Length:1,153
Mass (Da):130,489
Last modified:July 22, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1016BA2D69A7EA86
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DP000772 Genomic DNA Translation: ACE75821.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DP000772 Genomic DNA Translation: ACE75821.1

3D structure databases

SMRiB3EX63
ModBaseiSearch...

Proteomic databases

PRIDEiB3EX63

Family and domain databases

InterProiView protein in InterPro
IPR002928, Myosin_tail
PfamiView protein in Pfam
PF01576, Myosin_tail_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCING_SORAR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3EX63
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: July 22, 2008
Last modified: June 2, 2021
This is version 28 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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