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Entry version 19 (29 Sep 2021)
Sequence version 1 (09 Jul 2014)
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Protein

MAM and LDL-receptor class A domain-containing protein 2

Gene
N/A
Organism
Acropora millepora (Staghorn coral) (Heteropora millepora)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MAM and LDL-receptor class A domain-containing protein 2
Alternative name(s):
Skeletal organic matrix MAM and LDL-receptor 21 Publication
Short name:
SOM MAM and LDL-receptor 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcropora millepora (Staghorn coral) (Heteropora millepora)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri45264 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaScleractiniaAstrocoeniinaAcroporidaeAcropora

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000429551‹1 – ›7311MAM and LDL-receptor class A domain-containing protein 2Add BLAST›7311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2773 ↔ 2802Sequence analysis
Disulfide bondi2784 ↔ 2801Sequence analysis
Disulfide bondi2795 ↔ 2813Sequence analysis
Disulfide bondi2820 ↔ 2847Sequence analysis
Disulfide bondi2831 ↔ 2846Sequence analysis
Disulfide bondi2841 ↔ 2858Sequence analysis
Disulfide bondi3594 ↔ 3605Sequence analysis
Disulfide bondi3600 ↔ 3618Sequence analysis
Disulfide bondi3612 ↔ 3627Sequence analysis
Disulfide bondi3815 ↔ 3827Sequence analysis
Disulfide bondi3822 ↔ 3840Sequence analysis
Disulfide bondi3834 ↔ 3849Sequence analysis
Disulfide bondi4017 ↔ 4029Sequence analysis
Disulfide bondi4024 ↔ 4042Sequence analysis
Disulfide bondi4036 ↔ 4053Sequence analysis
Disulfide bondi4240 ↔ 4253Sequence analysis
Disulfide bondi4247 ↔ 4266Sequence analysis
Disulfide bondi4260 ↔ 4275Sequence analysis
Disulfide bondi4445 ↔ 4458Sequence analysis
Disulfide bondi4453 ↔ 4471Sequence analysis
Disulfide bondi4465 ↔ 4482Sequence analysis
Disulfide bondi4668 ↔ 4687Sequence analysis
Disulfide bondi4681 ↔ 4698Sequence analysis
Disulfide bondi4860 ↔ 4876Sequence analysis
Disulfide bondi4871 ↔ 4889Sequence analysis
Disulfide bondi4883 ↔ 4898Sequence analysis
Disulfide bondi5086 ↔ 5099Sequence analysis
Disulfide bondi5093 ↔ 5112Sequence analysis
Disulfide bondi5106 ↔ 5121Sequence analysis
Disulfide bondi5288 ↔ 5299Sequence analysis
Disulfide bondi5294 ↔ 5312Sequence analysis
Disulfide bondi5306 ↔ 5321Sequence analysis
Disulfide bondi5514 ↔ 5529Sequence analysis
Disulfide bondi5521 ↔ 5542Sequence analysis
Disulfide bondi5536 ↔ 5551Sequence analysis
Disulfide bondi5726 ↔ 5738Sequence analysis
Disulfide bondi5733 ↔ 5751Sequence analysis
Disulfide bondi5745 ↔ 5762Sequence analysis
Disulfide bondi5958 ↔ 5970Sequence analysis
Disulfide bondi5965 ↔ 5983Sequence analysis
Disulfide bondi5977 ↔ 5992Sequence analysis
Disulfide bondi6162 ↔ 6175Sequence analysis
Disulfide bondi6169 ↔ 6188Sequence analysis
Disulfide bondi6182 ↔ 6199Sequence analysis
Disulfide bondi6378 ↔ 6391Sequence analysis
Disulfide bondi6385 ↔ 6404Sequence analysis
Disulfide bondi6398 ↔ 6413Sequence analysis

Keywords - PTMi

Disulfide bond

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Component of the acid-insoluble and acid-soluble organic matrix of the aragonitic skeleton (at protein level).1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B3EWZ6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 171MAM 1PROSITE-ProRule annotationAdd BLAST168
Domaini199 – 361MAM 2PROSITE-ProRule annotationAdd BLAST163
Domaini363 – 530MAM 3PROSITE-ProRule annotationAdd BLAST168
Domaini532 – 695MAM 4PROSITE-ProRule annotationAdd BLAST164
Domaini727 – 887MAM 5PROSITE-ProRule annotationAdd BLAST161
Domaini889 – 1050MAM 6PROSITE-ProRule annotationAdd BLAST162
Domaini1052 – 1220MAM 7PROSITE-ProRule annotationAdd BLAST169
Domaini1228 – 1392MAM 8PROSITE-ProRule annotationAdd BLAST165
Domaini1394 – 1557MAM 9PROSITE-ProRule annotationAdd BLAST164
Domaini1559 – 1722MAM 10PROSITE-ProRule annotationAdd BLAST164
Domaini1755 – 1918MAM 11PROSITE-ProRule annotationAdd BLAST164
Domaini1920 – 2087MAM 12PROSITE-ProRule annotationAdd BLAST168
Domaini2089 – 2254MAM 13PROSITE-ProRule annotationAdd BLAST166
Domaini2274 – 2437MAM 14PROSITE-ProRule annotationAdd BLAST164
Domaini2439 – 2601MAM 15PROSITE-ProRule annotationAdd BLAST163
Domaini2603 – 2771MAM 16PROSITE-ProRule annotationAdd BLAST169
Domaini2771 – 2817P-type 1PROSITE-ProRule annotationAdd BLAST47
Domaini2818 – 2862P-type 2PROSITE-ProRule annotationAdd BLAST45
Domaini2883 – 3048MAM 17PROSITE-ProRule annotationAdd BLAST166
Domaini3050 – 3214MAM 18PROSITE-ProRule annotationAdd BLAST165
Domaini3216 – 3384MAM 19PROSITE-ProRule annotationAdd BLAST169
Domaini3429 – 3587MAM 20PROSITE-ProRule annotationAdd BLAST159
Domaini3593 – 3628LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST36
Domaini3632 – 3794MAM 21PROSITE-ProRule annotationAdd BLAST163
Domaini3814 – 3850LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST37
Domaini3850 – 4011MAM 22PROSITE-ProRule annotationAdd BLAST162
Domaini4016 – 4054LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST39
Domaini4058 – 4221MAM 23PROSITE-ProRule annotationAdd BLAST164
Domaini4239 – 4276LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST38
Domaini4277 – 4438MAM 24PROSITE-ProRule annotationAdd BLAST162
Domaini4444 – 4483LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST40
Domaini4486 – 4646MAM 25PROSITE-ProRule annotationAdd BLAST161
Domaini4660 – 4699LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST40
Domaini4700 – 4862MAM 26PROSITE-ProRule annotationAdd BLAST163
Domaini4859 – 4899LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST41
Domaini4903 – 5063MAM 27PROSITE-ProRule annotationAdd BLAST161
Domaini5085 – 5122LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST38
Domaini5123 – 5281MAM 28PROSITE-ProRule annotationAdd BLAST159
Domaini5287 – 5322LDL-receptor class A 9PROSITE-ProRule annotationAdd BLAST36
Domaini5326 – 5489MAM 29PROSITE-ProRule annotationAdd BLAST164
Domaini5513 – 5552LDL-receptor class A 10PROSITE-ProRule annotationAdd BLAST40
Domaini5554 – 5719MAM 30PROSITE-ProRule annotationAdd BLAST166
Domaini5725 – 5763LDL-receptor class A 11PROSITE-ProRule annotationAdd BLAST39
Domaini5768 – 5935MAM 31PROSITE-ProRule annotationAdd BLAST168
Domaini5957 – 5993LDL-receptor class A 12PROSITE-ProRule annotationAdd BLAST37
Domaini5994 – 6156MAM 32PROSITE-ProRule annotationAdd BLAST163
Domaini6161 – 6200LDL-receptor class A 13PROSITE-ProRule annotationAdd BLAST40
Domaini6204 – 6365MAM 33PROSITE-ProRule annotationAdd BLAST162
Domaini6377 – 6414LDL-receptor class A 14PROSITE-ProRule annotationAdd BLAST38
Domaini6430 – 6590MAM 34PROSITE-ProRule annotationAdd BLAST161
Domaini6606 – 6779MAM 35PROSITE-ProRule annotationAdd BLAST174
Domaini6808 – 6965MAM 36PROSITE-ProRule annotationAdd BLAST158
Domaini7173 – ›7311MAM 37PROSITE-ProRule annotationAdd BLAST›139

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2461 – 2481DisorderedSequence analysisAdd BLAST21
Regioni6014 – 6034DisorderedSequence analysisAdd BLAST21

Keywords - Domaini

Repeat

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 15 hits
cd06263, MAM, 37 hits
cd00111, Trefoil, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.400.10, 15 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR000998, MAM_dom
IPR017957, P_trefoil_CS
IPR000519, P_trefoil_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00057, Ldl_recept_a, 8 hits
PF00629, MAM, 37 hits
PF00088, Trefoil, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR
PR00020, MAMDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00192, LDLa, 15 hits
SM00137, MAM, 37 hits
SM00018, PD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 37 hits
SSF57424, SSF57424, 14 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01209, LDLRA_1, 12 hits
PS50068, LDLRA_2, 14 hits
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 37 hits
PS00025, P_TREFOIL_1, 1 hit
PS51448, P_TREFOIL_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

B3EWZ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
NQPAYCDFEK DNWCTWTNSD KEDDFDWLLG SGSTPSVYTG PSNDHTTGLG
60 70 80 90 100
IGKYMFIETS SPRKSGDKAR FYSERLSPTS LRGRCVKFWY HMYGSSIGTL
110 120 130 140 150
KVFVKTGAGN RSESLVWSLS GNQRNRWNFG QVTIASYRSA YQIVFEGIRG
160 170 180 190 200
NSYRGDIAID DITYTVGSCV TLPRGAVPTT PPTTVRPTTS PTVPPKGALD
210 220 230 240 250
CDFERGFCSW VQDSSDKFNW TRQSRGTASS NTGPSADHTL KNATGYYAYI
260 270 280 290 300
EASFPRRAND TARLISPLIP ANSRPGMCIS FWYHMYGPHI DTLNVYTKVG
310 320 330 340 350
SSLGSAIWKK TGNQGNKWRY GQVFVRMVLN FQIVFEGVRG RSYQGDIAID
360 370 380 390 400
DVTVRNGFCS PLKQCTFEDA GMCGWRNEKS AGVDDFDWTR QSGATSSSGT
410 420 430 440 450
GPTFDHTLGT ARGFYMYIET SFPRKQGDKA QLLSPSYPST SGKCLRFWYH
460 470 480 490 500
MYGNHIGTLN IRIKQMVLGR PTYFLQWSRS GDHGNNWRVA QVTIRSGSQF
510 520 530 540 550
QVVFEGIRGS GYQGDIAIDD VELKDNVCPP PGDCNFETGT CNWVNVQNTD
560 570 580 590 600
NFDWLRGRGS TPSSFTGPSV DHTTNSSSGY YMFIETSSPR RIGDKARFES
610 620 630 640 650
EEFQPTGSSG RCLKFWYHMY GSSVRGLNVW MSSNGSTGQI WTLSGNQRQD
660 670 680 690 700
KWFYAQAPVR SANVYQVIFE GVRGLSYAGD IAIDDVQFIV GNCPVLPSKA
710 720 730 740 750
KPLNPWTPRP VPTVAPTNST TPAPSIYDCT FEQSMCTWTQ ALDDSFNWTR
760 770 780 790 800
TKGRTPSRFT GPVSDHTTGG SAGYYVYIET SSPRKANETA RIESVTIPAT
810 820 830 840 850
QQKCLQFWYH MYGPHVDTLN VYTKINNQLG VPVWTLNGTQ GNKWRHAVVS
860 870 880 890 900
LTVSSKFKVV FEGRRGVSWA GDIALDDISF QDGQCPVQMQ CSFENPNLCG
910 920 930 940 950
WSNVQGDNFD WTRSNGYTSS SGTGPSVDHT SGTSNGYYMY IETSSPRSRG
960 970 980 990 1000
HKAWFVSSPF KATNGRCLQF WYHMYGATIG ALNVLLLQNR TRSAPIWNLS
1010 1020 1030 1040 1050
GNQGNLWRMA QVTLKSPTDF KVIFEGVTGT SYTGDIAIDD VEIMDGACPL
1060 1070 1080 1090 1100
PGDCTFEKGT CTWVNSLNVV DDEFDWTRGS GGTPSSFTGP STDHTTGTKN
1110 1120 1130 1140 1150
GNYMFIETSF PRKRGDRARL ESEVFPPTTS TGRCMSFWYH MMGGHIGTLN
1160 1170 1180 1190 1200
VYMKIYGQSE TKLWSMTLDQ GNNWNSARVP IVSGNRYYQI ILEGVRGSSY
1210 1220 1230 1240 1250
QGDIAIDDIS FVATARRCRL SPSNAVPFDC NFELGTCSWT QSFRDQFHWT
1260 1270 1280 1290 1300
RHQGSTGSFL TGPSIDHTTA TNKGWYIYIE TSGPRRPNDT ARIVSPTIAG
1310 1320 1330 1340 1350
NGTVKVIRCV SFWYHMYGPH VDELRLYKKE GFSLGKPQWV RQGDQGNKWI
1360 1370 1380 1390 1400
KGEYTVEHTN GIQIVFEGVR GVSYRGDIAL DDISLKDGSC PSSGMCSFEA
1410 1420 1430 1440 1450
PDICGYTQDH DTDQFDWSRS NGPTASFSTG PAADHTYGTL FGHFMYTEVS
1460 1470 1480 1490 1500
PSSITQGSKA RLLSPRYPAT RGSCLQFWYH MYGQTIGTLN VYTRRSSWSL
1510 1520 1530 1540 1550
NKVWSKTGND TNIWNVAQVT IRSPFAYQIV FEGVKGRSYT GDIAIDDVKI
1560 1570 1580 1590 1600
MSGSCPAPGD CSFEKGFCTW ANTRQVDTFD WIIGGGTTSS FGTGPSGDHT
1610 1620 1630 1640 1650
TGSGQYVFIE TSAPRQHGDN AYLLSQPFDP APSGRCLKFW HHMRGASIGT
1660 1670 1680 1690 1700
LNVYLHTGNF SAMQLLWQRN GNKGSTWMIG QTPITSSVKY QVVFEGIRGN
1710 1720 1730 1740 1750
SFTGDIALDD ISFTVGAANC IQRPYDSLPP GVTTSAPTLS TSSSVAPTTI
1760 1770 1780 1790 1800
GNIGNDCNFD VGICKWTFAS YGQFNWTRHQ GSTASSGTGP KYDHTRGNSG
1810 1820 1830 1840 1850
QGYYMYIETS VPRRPNDTAG LVSPKVQKVG SFACVIFWYH MFGPHINQLN
1860 1870 1880 1890 1900
VYFKDGSKAK TLMWQKIGSQ ADEWRQGLLQ LSPSQGSYQV IFEGVRGTSY
1910 1920 1930 1940 1950
QGDISLDDIS FQNNKCPSST DCTFEYFLGS ISNTCGWTQD GSDDFDWTRT
1960 1970 1980 1990 2000
SGGTPSHATG PSADHTYGTS QGYYMHIETS YPRRRGDKAR LISPVYRPVR
2010 2020 2030 2040 2050
GGQCFQFWYH MYGSDIDRLN VYIKTGSNIS IPVWSRSGNR GDLWKISQVP
2060 2070 2080 2090 2100
VTTTVNFNIV IEGIAGRSFR GDIAIDDLKL IKSPCPLPGD CDFESGMCTY
2110 2120 2130 2140 2150
DNTQAEDQFD WLRNAGATPS WRTGPSVDHT LGTGFGHYMY IETSSPRRQG
2160 2170 2180 2190 2200
DKARLMSEDF NPTTSSGRCV RFWYHLYGNA IGTLRVLVKT GPGNQSETAI
2210 2220 2230 2240 2250
WELSGNFGNQ WYSAQAPVSS AKVYQVVFEG VRGRGVSGDI AIDDITFATT
2260 2270 2280 2290 2300
RCSVVPSLAV PPTPPPTTPP PVINNCTFEG GFCSWKNLRG DNFDWTRSRG
2310 2320 2330 2340 2350
ATSSWRTGPT TDHTLGTRAG YYVYIETSFP RRSKDKAWLQ SGLIQPTTVT
2360 2370 2380 2390 2400
NGRCLKFWYH MWGTHVDTLN VYRKVGSSPN VRIWFRRGTQ GNKWRFAQVN
2410 2420 2430 2440 2450
LLSNQPFYVI FEGVRGLSYQ GDIALDDLDI ADGPCPPLTV CDFETDMCKW
2460 2470 2480 2490 2500
TNIAIGDQFD WKRDSGGTPS AGTGPSRDHT TGTRNGMYMY IETSLPRRQG
2510 2520 2530 2540 2550
DKAYFISPRY DAAPNGKCFK FWYHMYGRHI GKLNIYVKAG PALGAMVWNE
2560 2570 2580 2590 2600
TGNQGNFWLH GKAPVKISTQ FQIVIEGIRG ASYAGDIALD DFSLDDSPCP
2610 2620 2630 2640 2650
PEGSCDFEEK SFCSWLNVPN GNKSLGLDDF DWTLGSGSTP SWQTGPSTDH
2660 2670 2680 2690 2700
TTGSSLGTYA FIETSNPRRA GHIARIRSKT FSATNGKCMS WWFHMYGRSV
2710 2720 2730 2740 2750
GSLNVYIKKG GSPESLLWNT KGNQGNVWKK TEVTITSKSD FQIIFEGVSG
2760 2770 2780 2790 2800
AGFQGDIAID DIDFADKYCV GLCSSVNPQQ RVDCSGGLGI SKTTCVNLRR
2810 2820 2830 2840 2850
CCWDDSVPNV PVCFYHPSAC ASVIPANRRT CGFSGISSSQ CRTRGCCWDN
2860 2870 2880 2890 2900
SLSNVPWCFH GPARPTDFPT QPPPPTTLPP SKWDCTFESG FCNWNNSQED
2910 2920 2930 2940 2950
DFNWSRQSGG SPSIGTGPTS DHTTGSLRGY YVYIETSYGS ANDTAVLESA
2960 2970 2980 2990 3000
MVPATIRKPS GMICLQFWYH MRGQHVDTLN VFVKPGNQLP SSPTWTKSGT
3010 3020 3030 3040 3050
QGTQWRLGQV AVSSRAPFQF VFQGIRGKGY QGDIALDDIR VLDGTCPPSR
3060 3070 3080 3090 3100
ECDFESPNLC NFTQDTGDIF DWSRGSGNTI SVGTGPSYDH TYKTASGYYM
3110 3120 3130 3140 3150
YIETSAPRRT GDYARIESIS YDQTVGNGRC LVFWHHMYGG GIGRLNVYIK
3160 3170 3180 3190 3200
RGNSLGTPVW RKNGNHGNKW WRGMVTVRSP NQKWKVVFEG IRGRGGRGDI
3210 3220 3230 3240 3250
AIDDIIVKDQ PCPPPGSCDF ESGWCAYQND LTGDDFDWER NTGHTSSIGT
3260 3270 3280 3290 3300
GPSVDHTTGS PQGHYVYIES SYPRTKGDVA RLTSDLFEVS KGYAWCLSFW
3310 3320 3330 3340 3350
YHMYGNSVGS LSVKITIYPF RKDKPYTRLL WTQQLNHGDV WLTDTVQINS
3360 3370 3380 3390 3400
PDDFEIVFEA VVGSSYDADI AIDDIVVTAG FCPSPKPTVA PNPCAVRCKS
3410 3420 3430 3440 3450
NNKCVSSTQL CDFVNDCGRG DNSDEKNCGA CTFEQDLCGW NDTSKGAFKW
3460 3470 3480 3490 3500
NKDRGGTPSS NTGPTIDHTL GTALGYYMYV EASQGRIRDM AQLESPWLKQ
3510 3520 3530 3540 3550
SASTCVVSFW YHMYGRGIGR LYGYIKVGLT YTRLFQQSGN KGNNWLQGKL
3560 3570 3580 3590 3600
YVGRRFAPFK IIFEAERSYN VFGDVAVDDV SFVNCTLPPI VSSCGQQHRC
3610 3620 3630 3640 3650
IRGSCIDRGR VCDYTDDCGD NSDEQNCYNF KYRCSFEKSL CQWTQLKDEE
3660 3670 3680 3690 3700
FDWTRNQGVT ASYNTGPMFD HTLGTAAGYY LYAEASYPRK KGDKARLASG
3710 3720 3730 3740 3750
FITTPGDDSC KLRLYFHMFG SGIGSLNVYT RPCNGCAETL VYTRSGNLGN
3760 3770 3780 3790 3800
FWERAEVALM SRVPFQVIIE SVRGVSYLGD IAIDDLSMTS SCQSYRGPLP
3810 3820 3830 3840 3850
TAPPPTTAIP TPPPCPRFQF KCSNGLCIDT WNVCNYRDDC GDGSDEVNCG
3860 3870 3880 3890 3900
SCSFEPGLCG YQDVSLTLYQ WSRNRGTTVV PRTGPSVDHT CGNASCFYAY
3910 3920 3930 3940 3950
VHSGAGSFFD DAILQSRNMT KTGPGCVVSF YYHMYSRLSA GFTGTLYLRL
3960 3970 3980 3990 4000
KYKGTTSNLF EVYGNNGDKW KRAEVGLGSL DAGFSIQFVA SKFVTAADIA
4010 4020 4030 4040 4050
VDDVTFQGCA LPPIRSCISG EYRCTRGSCV LPSQLCDFSD DCGDMSDENP
4060 4070 4080 4090 4100
STCASYKERC NFEQDLCSWT QDTDDDFDWT KDSGGTPSSW TGPGRDHTKG
4110 4120 4130 4140 4150
SSKGFYMYIE TSSPRKSNES ARMSSMTFRP SSRNDSCYMR FWYHMFGKDV
4160 4170 4180 4190 4200
DTLSIKLRIS MIGPLIPLWN RTGEQGDMWR RAEIHLASNV NFQVVIEGLS
4210 4220 4230 4240 4250
GPGFQGDIAI DDVSFTPNCR PDSTASISTT IPTGPPIPGC QPGKFKCANG
4260 4270 4280 4290 4300
GNCISVSKVC NFYSDCSGGS DEMNCPATCN FQNSFCKWQN AKSVDHYDWV
4310 4320 4330 4340 4350
RNKGQTPSRF TGPSVDHTTN SSAGYYIYTE VSNRTGFFAD AHLVSPLFRQ
4360 4370 4380 4390 4400
AGKNCQFKFW YHMFGPNIGF LQVFYRRNSR DQQLFSVFGN KGNKWNQGTV
4410 4420 4430 4440 4450
DIPKCANDFR IVIMAKHYSG GALGDIAVDD VSFEHCAESP PSQTCSGLSV
4460 4470 4480 4490 4500
FRCQSGHCIA MSGKCDFEPD CCDGSEETNI VCAKYNRCNF EAGLCDWTQL
4510 4520 4530 4540 4550
ANDTFNWRMQ SGRTGSHRTG PSLDHTTRSR NGRYMYIEAS SPRKPGDSAI
4560 4570 4580 4590 4600
LGSAVFKPTG SCKLRFFYHM YGSHIGHLNV SIRTSTNGPS TVLWTKSGDQ
4610 4620 4630 4640 4650
GDKWTRATVS ISVSKNFQVL IEGVVGSSYR GDIAIDDISF TPDCVVGGTI
4660 4670 4680 4690 4700
PGLPPPPPTP TQPSCFNCRD GSACVNISKT CDFHNDCTDK SDEDADLCGW
4710 4720 4730 4740 4750
PCDFQRGTCS WTNSNRDNFD WTRHKGCTAS VSTGPCVDAD NRTSGYYMYI
4760 4770 4780 4790 4800
ETSTGLIGNK AVLVSPRYQQ AYSTAQLSFW YHMYGRTIGR LSVYLNDGIN
4810 4820 4830 4840 4850
RTRMWTLYGN QGDQWYQTFI SLGRRRTPFT IEFEALRGSS WSGDIAIDSI
4860 4870 4880 4890 4900
SMNNYTLTYC SGQLPPTKWR CRNGACVDAN ALCDFSDDCG DNSDEQSCSN
4910 4920 4930 4940 4950
YFSRCTFENG LCDWFQGSGD EIDWIRNKGP TPSFSTGPSR DHTLGTVEGY
4960 4970 4980 4990 5000
YLYMEATGQK FGDRARLASN NLMGKCNLRM FYHMHGIHVN SLAVYMRTKL
5010 5020 5030 5040 5050
NGPLRVVANM SGSVGDNWIR SEVNVTNGDQ PFQIVIEGVR GRGYRGDIAI
5060 5070 5080 5090 5100
DDLSIAMKPS CQQFFGSLPW LGSTVKPITT VAPNNCVLPQ VPCVSDGKCV
5110 5120 5130 5140 5150
SPSQVCDFNL DCADASDERS CPHMCTFESD QCGWVNTVKD NFDWSRKRGR
5160 5170 5180 5190 5200
TPSFGTGPSV DHTTGTNQGY YMYIETSYGR IGDRARLISP QFKKSHSNCK
5210 5220 5230 5240 5250
MVFWYHMYGS SIGSLSVYLN VSSNTKLWWR KYGYQGNQWY RGVVGIGKRS
5260 5270 5280 5290 5300
NAFQIIFLGI RGRSYSGDIA IDDIKFVDCA LPPVARSCPS QFTCARNSCV
5310 5320 5330 5340 5350
SNDYVCDFND DCGDGSDETL CGAYTTRCDF SRGSCDWTQS NEDDFNWLRR
5360 5370 5380 5390 5400
KGATSSFNTG PPSDHTSQTG YYMYIETSWP RRYGDKAWLV SRNFQEMTPG
5410 5420 5430 5440 5450
SESCKLRFFY HMFGDSAESL NVYIRTYRNG SALQRVWGVK GSRGAIWNRA
5460 5470 5480 5490 5500
VITLSSRKNF QVLIEGIRGD SYTGDIGIDD VSFTTGCKQF SGNLPVAPPI
5510 5520 5530 5540 5550
SPTSNPATTK PHQCTTAEFN CFNQGSGACI PSTQVCNFQP NCNDGVDEQN
5560 5570 5580 5590 5600
CAKTKCSFDG GDFCNWYVNN PSRTRRALAY TWLAQQGATG SSGTGPTKDH
5610 5620 5630 5640 5650
TTGTLSGWYI YAESSGGSND DRAPLTTPLI GQTGPECTLL FWYHMFGVSV
5660 5670 5680 5690 5700
GTLSVKLSFL DGTQSVMWSK SGSQGNRWRQ SKLMIGSRQL FKVTFEARRS
5710 5720 5730 5740 5750
YGYKGDIALD DIEFLNCVPL DLTKKCTADE FQCARGGCIP KTSVCDFKAD
5760 5770 5780 5790 5800
CMVGDVSDES SCSAYRSGQC DFEHGLCLYS QSSDDKFDWT VKTGGTFSYN
5810 5820 5830 5840 5850
TGPTIDHTTK SKKGHYMYIE TSWPRRNGDN ARLNSPILKS TSSNCYLRFF
5860 5870 5880 5890 5900
YHMKGNHIGN LSVFSRTGYS VGDLSGPLLN ITGAQGDFWN RSMVKAPVSS
5910 5920 5930 5940 5950
NDFQFVIEGV RGNGYQGDIA IDDVSLTPGC QICTDCTLPG QPTSTPFGFH
5960 5970 5980 5990 6000
TRPTGTPCSL QQYVCKNLRC VDKAQICNFK DDCGDNSDEL PCGSNCTFEG
6010 6020 6030 6040 6050
DCYRGWRQST GSSNFHWRRR NGKTPSVGTG PTNDHTFGNQ NGYYMYIETS
6060 6070 6080 6090 6100
NGSPGDKAEL ASYRYFASSP NCRMSLWYHM FGTGVGSLEV KLKKSDGTYE
6110 6120 6130 6140 6150
ILGNALTGSQ GNAWKKYTLN IGANKNFEIL IVAARGINWQ GDIAIDDISF
6160 6170 6180 6190 6200
TDNCFVDLNR TCTPNEVKCR TSGHCVAEQR VCDHVKDCND GTDEDALICS
6210 6220 6230 6240 6250
NRTASCDFDV NWCQWDNYWV DDFNWLRASA IGTPNTGPRA DHTTGKGYFL
6260 6270 6280 6290 6300
YIDSSKPRQL FDKARLVHPN VFPSGRGVCT LRFYYNMYGS QNMGYLNVYL
6310 6320 6330 6340 6350
VYSGYSQWTQ VWRTRGDPAN RLWVRAEIQL NSQSSFRVGF EGIVGGGDKT
6360 6370 6380 6390 6400
DIALDDISFS AGCYKGGSPP LPTGSARCSK VQFYCKADDL CINIHWKCDG
6410 6420 6430 6440 6450
EKDCTDGADE MLCPSPTKQP TPPPGLTHPA NCNFESGFCL WRSAFFADMN
6460 6470 6480 6490 6500
WLRNRGQTPS RQTGPDGDHT TGTGYYVYAE ATGHYMNQFG ELLGPNMMPS
6510 6520 6530 6540 6550
STCKVYFCYL MHGKDMGTLN VYQRFPSDKK PDQTQKRKWS QSLDFGKKWR
6560 6570 6580 6590 6600
CVYVPLPSTR QFSVVFEAIR GKGYRSDIAL DDIKFVNCAK LGPTQKPTPA
6610 6620 6630 6640 6650
PRGTILDEDF EDCISCWMNE KNGHDQMDWV IGRGETSSLN TGPSYDHTRK
6660 6670 6680 6690 6700
TIYGRYLYID VYSASHIQGW VHADLESRLM VVQRRCYMTF WYHMYGAGMG
6710 6720 6730 6740 6750
SLWIVAYVYD DPKNLNDWRE VSLWYSYGNQ GNKWTSGKVN LFNHLTASKT
6760 6770 6780 6790 6800
SRVVISGIRG SDYTGDIAID DIKFHNCDFK DDKTPCGEVF DRCNDRPIPK
6810 6820 6830 6840 6850
PTLGPASGDC TFESGLCHWN NTIVNDMPWF LRKGKTGSQY TGPAVDHTLG
6860 6870 6880 6890 6900
TPDGYYVHIE ASWYTRGSVA ILEGPYTLPT QNCEMKFYYH MFGGDCGSLL
6910 6920 6930 6940 6950
VYINSGDSVK LVFNKTGEQG KDWLGASVQL KSDYAFRIHI TATRGSSYKG
6960 6970 6980 6990 7000
DIAIDDISFK GQCQFTSNAA LRYGDKLLTT GCADGGREGF FSHPSVAGCK
7010 7020 7030 7040 7050
GRWSRPESLR AKPTSGAKCG DDIGLWGRSC SQPAELCATG WHICGSYGVR
7060 7070 7080 7090 7100
EIVNRTNGID CQEAGYGKFS AGINHCMQNN AGGDGCKRVV TDIDYGCGKY
7110 7120 7130 7140 7150
YDSCSEPLCC GSNCQGPDIC DSGVFRAATR YSASSEHLEG CSFISSDNAG
7160 7170 7180 7190 7200
GIMCCKDDAT TPTPAPTMPP VPGSCNFETG LCGWIVDSST ALSFGLGQGE
7210 7220 7230 7240 7250
TVTRNTGPRY DNTKKDMTGT YLSMPAVNGK PNDIARVSHH FSNVTQSYCQ
7260 7270 7280 7290 7300
INFFYHMYGA GMGSLRVFVE LDGGGKKKVW EKTGNQGDGW LRGAQNFSGA
7310
DQEDDCIYNN L
Length:7,311
Mass (Da):810,540
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF50CDFD66E6F1C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Curated1
Non-terminal residuei7311Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JR994474 mRNA No translation available.

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JR994474 mRNA No translation available.

3D structure databases

SMRiB3EWZ6
ModBaseiSearch...

Family and domain databases

CDDicd00112, LDLa, 15 hits
cd06263, MAM, 37 hits
cd00111, Trefoil, 2 hits
Gene3Di4.10.400.10, 15 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR000998, MAM_dom
IPR017957, P_trefoil_CS
IPR000519, P_trefoil_dom
PfamiView protein in Pfam
PF00057, Ldl_recept_a, 8 hits
PF00629, MAM, 37 hits
PF00088, Trefoil, 2 hits
PRINTSiPR00261, LDLRECEPTOR
PR00020, MAMDOMAIN
SMARTiView protein in SMART
SM00192, LDLa, 15 hits
SM00137, MAM, 37 hits
SM00018, PD, 2 hits
SUPFAMiSSF49899, SSF49899, 37 hits
SSF57424, SSF57424, 14 hits
PROSITEiView protein in PROSITE
PS01209, LDLRA_1, 12 hits
PS50068, LDLRA_2, 14 hits
PS00740, MAM_1, 1 hit
PS50060, MAM_2, 37 hits
PS00025, P_TREFOIL_1, 1 hit
PS51448, P_TREFOIL_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLRP2_ACRMI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3EWZ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: July 9, 2014
Last modified: September 29, 2021
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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