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Entry version 20 (29 Sep 2021)
Sequence version 1 (09 Jul 2014)
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Protein

MAM and LDL-receptor class A domain-containing protein 1

Gene
N/A
Organism
Acropora millepora (Staghorn coral) (Heteropora millepora)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MAM and LDL-receptor class A domain-containing protein 1
Alternative name(s):
Skeletal organic matrix MAM and LDL-receptor 11 Publication
Short name:
SOM MAM and LDL-receptor 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcropora millepora (Staghorn coral) (Heteropora millepora)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri45264 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaScleractiniaAstrocoeniinaAcroporidaeAcropora

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000429550‹1 – ›5145MAM and LDL-receptor class A domain-containing protein 1Add BLAST›5145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3024 ↔ 3053Sequence analysis
Disulfide bondi3035 ↔ 3052Sequence analysis
Disulfide bondi3046 ↔ 3064Sequence analysis
Disulfide bondi3071 ↔ 3098Sequence analysis
Disulfide bondi3082 ↔ 3097Sequence analysis
Disulfide bondi3092 ↔ 3109Sequence analysis
Disulfide bondi3845 ↔ 3856Sequence analysis
Disulfide bondi3851 ↔ 3869Sequence analysis
Disulfide bondi3863 ↔ 3878Sequence analysis
Disulfide bondi4066 ↔ 4078Sequence analysis
Disulfide bondi4073 ↔ 4091Sequence analysis
Disulfide bondi4085 ↔ 4100Sequence analysis
Disulfide bondi4268 ↔ 4280Sequence analysis
Disulfide bondi4275 ↔ 4293Sequence analysis
Disulfide bondi4287 ↔ 4304Sequence analysis
Disulfide bondi4491 ↔ 4504Sequence analysis
Disulfide bondi4498 ↔ 4517Sequence analysis
Disulfide bondi4511 ↔ 4526Sequence analysis
Disulfide bondi4696 ↔ 4709Sequence analysis
Disulfide bondi4704 ↔ 4722Sequence analysis
Disulfide bondi4716 ↔ 4733Sequence analysis
Disulfide bondi4919 ↔ 4938Sequence analysis
Disulfide bondi4932 ↔ 4949Sequence analysis
Disulfide bondi5111 ↔ 5127Sequence analysis
Disulfide bondi5122 ↔ 5140Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
B3EWZ5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Component of the acid-insoluble and acid-soluble organic matrix of the aragonitic skeleton (at protein level).1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B3EWZ5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini‹1 – 94MAM 1PROSITE-ProRule annotationAdd BLAST›94
Domaini97 – 259MAM 2PROSITE-ProRule annotationAdd BLAST163
Domaini261 – 428MAM 3PROSITE-ProRule annotationAdd BLAST168
Domaini458 – 758MAM 4PROSITE-ProRule annotationAdd BLAST301
Domaini760 – 923MAM 5PROSITE-ProRule annotationAdd BLAST164
Domaini925 – 1092MAM 6PROSITE-ProRule annotationAdd BLAST168
Domaini1120 – 1282MAM 7PROSITE-ProRule annotationAdd BLAST163
Domaini1284 – 1451MAM 8PROSITE-ProRule annotationAdd BLAST168
Domaini1453 – 1616MAM 9PROSITE-ProRule annotationAdd BLAST164
Domaini1648 – 1808MAM 10PROSITE-ProRule annotationAdd BLAST161
Domaini1810 – 1973MAM 11PROSITE-ProRule annotationAdd BLAST164
Domaini2006 – 2169MAM 12PROSITE-ProRule annotationAdd BLAST164
Domaini2171 – 2338MAM 13PROSITE-ProRule annotationAdd BLAST168
Domaini2340 – 2505MAM 14PROSITE-ProRule annotationAdd BLAST166
Domaini2525 – 2688MAM 15PROSITE-ProRule annotationAdd BLAST164
Domaini2690 – 2852MAM 16PROSITE-ProRule annotationAdd BLAST163
Domaini2854 – 3022MAM 17PROSITE-ProRule annotationAdd BLAST169
Domaini3022 – 3068P-type 1PROSITE-ProRule annotationAdd BLAST47
Domaini3069 – 3113P-type 2PROSITE-ProRule annotationAdd BLAST45
Domaini3134 – 3299MAM 18PROSITE-ProRule annotationAdd BLAST166
Domaini3301 – 3465MAM 19PROSITE-ProRule annotationAdd BLAST165
Domaini3467 – 3635MAM 20PROSITE-ProRule annotationAdd BLAST169
Domaini3680 – 3838MAM 21PROSITE-ProRule annotationAdd BLAST159
Domaini3844 – 3879LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST36
Domaini3883 – 4045MAM 22PROSITE-ProRule annotationAdd BLAST163
Domaini4065 – 4101LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST37
Domaini4101 – 4262MAM 23PROSITE-ProRule annotationAdd BLAST162
Domaini4267 – 4305LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST39
Domaini4309 – 4472MAM 24PROSITE-ProRule annotationAdd BLAST164
Domaini4490 – 4527LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST38
Domaini4528 – 4689MAM 25PROSITE-ProRule annotationAdd BLAST162
Domaini4695 – 4734LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST40
Domaini4737 – 4897MAM 26PROSITE-ProRule annotationAdd BLAST161
Domaini4911 – 4950LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST40
Domaini4951 – 5113MAM 27PROSITE-ProRule annotationAdd BLAST163
Domaini5110 – ›5145LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST›36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni484 – 511DisorderedSequence analysisAdd BLAST28
Regioni2712 – 2733DisorderedSequence analysisAdd BLAST22

Keywords - Domaini

Repeat

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 8 hits
cd06263, MAM, 27 hits
cd00111, Trefoil, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.400.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR000998, MAM_dom
IPR017994, P_trefoil_chordata
IPR017957, P_trefoil_CS
IPR000519, P_trefoil_dom
IPR035992, Ricin_B-like_lectins

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00057, Ldl_recept_a, 4 hits
PF00629, MAM, 27 hits
PF00088, Trefoil, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR
PR00020, MAMDOMAIN
PR00680, PTREFOIL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00192, LDLa, 8 hits
SM00137, MAM, 26 hits
SM00018, PD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 28 hits
SSF50370, SSF50370, 1 hit
SSF57424, SSF57424, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01209, LDLRA_1, 6 hits
PS50068, LDLRA_2, 7 hits
PS00740, MAM_1, 2 hits
PS50060, MAM_2, 27 hits
PS00025, P_TREFOIL_1, 1 hit
PS51448, P_TREFOIL_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

B3EWZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
QVPATTGSNG KCLSFWYHMY GADINTLSVY VRTGSHDTLL WSKSGTRGDK
60 70 80 90 100
WIKALVSVTS RSPFKIVMAA SVGRSYQGDI ALDDISMSSG ACKVSSTTCT
110 120 130 140 150
FEESHMCGYT QDTKIDNFDW RRGSGASITP NTGPSADHTL GSPAGFYMYI
160 170 180 190 200
DSSSQRKGYF ARLLSPPMQR TRAKCLQFWY HMYGSTVGSL SVYKLVTPTR
210 220 230 240 250
GPRIWRMSGN LGDEWLVAQV SVWSPLRSYN IAFQARVGNG GNGDIAIDDV
260 270 280 290 300
VVFNGRCASP GNCDFERGTC TWRNTRKQDD FDWLQGKGNT LSITTGPSTD
310 320 330 340 350
HTTNSANGTY MFIEASSPRR LNDKARFTSQ QFSPVSVRGR CLKFWYHMLG
360 370 380 390 400
ADIGTLNVIQ KTGPGNRSEI LLWTLSGQQG NTWLNARVSL SKSPNTNYWI
410 420 430 440 450
VFEGVRGNGY RGDIAIDDIQ FTNADCRILP AKARPSKPTL PPPTTRFTLP
460 470 480 490 500
PTIPPSLYNC DFENGFCNYT QEHITDVFNW TRRQGGTSSG GTGPVRDHTK
510 520 530 540 550
QQGVVVGPNG PGSLQQLRTG RCVHVFLGGF RKPPAGRSVV YYNGCGQGRL
560 570 580 590 600
EFQLTSDGYM KFTKFNMCWR RRGGPGSNAD DVVLADSCTE KWRFTSAKSI
610 620 630 640 650
QHIGTAKCVA PHLGSAVNDR KLVLSSSCDQ RNQIFRWQPT LGWYIYIEAS
660 670 680 690 700
WPRQPNDTAR IHSPIITSAP SQQRCLSFWY HMYGRHIASL NVYTKVGNTF
710 720 730 740 750
NGPVWSKSGT QGNKWWNGKV PVSNLNAYQI VFEGVRGSSY QGDIALDDIE
760 770 780 790 800
LLNSACPATM NCDFESPLSQ LKICGWTQRS DDNFDWRLGR GATSSINTGP
810 820 830 840 850
SNDHTLGNQK GHYLFIETSI VRQGSKAWLQ GPQISPQSGK CFQFWYHMYG
860 870 880 890 900
SSIGQLNVYI LRSQSVPSSP VWSRQRNQGN SWYIAQISIT QAGYLLFEGV
910 920 930 940 950
RGASFTGDIA IDDFKLMDGA CNQPAYCDFE KDNWCTWTNS DKEDDFDWLL
960 970 980 990 1000
GSGSTPSVYT GPSNDHTTGL GIGKYMFIET SSPRKSGDKA RFYSERLSPT
1010 1020 1030 1040 1050
SLRGRCVKFW YHMYGSSIGT LKVFVKTGAG NRSESLVWSL SGNQRNRWNF
1060 1070 1080 1090 1100
GQVTIASYRS AYQIVFEGIR GNSYRGDIAI DDITYTVGSC VTLPRGAVPT
1110 1120 1130 1140 1150
TPPTTVRPTT SPTVPPKGAL DCDFERGFCS WVQDSSDKFN WTRQSRGTAS
1160 1170 1180 1190 1200
SNTGPSADHT LKNATGYYAY IEASFPRRAN DTARLISPLI PANSRPGMCI
1210 1220 1230 1240 1250
SFWYHMYGPH IDTLNVYTKV GSSLGSAIWK KTGNQGNKWR YGQVFVRMVL
1260 1270 1280 1290 1300
NFQIVFEGVR GRSYQGDIAI DDVTVRNGFC SPLKQCTFED AGMCGWRNEK
1310 1320 1330 1340 1350
SAGVDDFDWT RQSGATSSSG TGPTFDHTLG TARGFYMYIE TSFPRKQGDK
1360 1370 1380 1390 1400
AQLLSPSYPS TSGKCLRFWY HMYGNHIGTL NIRIKQMVLG RPTYFLQWSR
1410 1420 1430 1440 1450
SGDHGNNWRV AQVTIRSGSQ FQVVFEGIRG SGYQGDIAID DVELKDNVCP
1460 1470 1480 1490 1500
PPGDCNFETG TCNWVNVQNT DNFDWLRGRG STPSSFTGPS VDHTTNSSSG
1510 1520 1530 1540 1550
YYMFIETSSP RRNRDKARFE SEEFQPTGSS GRCLKFWYHM YGSSVRGLNV
1560 1570 1580 1590 1600
WMSSNGSTGQ IWTLSGNQRQ DKWFYAQAPV RSANVYQVIF EGVRGLSYAG
1610 1620 1630 1640 1650
DIAIDDVQFI VGNCPVLPSK AKPLNPWTPR PVPTVAPTNS TTPAPSIYDC
1660 1670 1680 1690 1700
TFEQSMCTWT QALDDSFNWT RTKGRTPSRF TGPVSDHTTG GSAGYYVYIE
1710 1720 1730 1740 1750
TSSPRKANET ARIESVTIPA TQQKCLQFWY HMYGQTIGTL NVYTRRSSWS
1760 1770 1780 1790 1800
LNKVWSKTGN DTNIWNVAQV TIRSPFAYQI VFEGVKGRSY TGDIAIDDVK
1810 1820 1830 1840 1850
IMSGSCPAPG DCSFEKGFCT WANTRQVDTF DWIIGGGTTS SFGTGPSGDH
1860 1870 1880 1890 1900
TTGSGQYVFI ETSAPRQHGD NAYLLSQPFD PAPSGRCLKF WHHMRGASIG
1910 1920 1930 1940 1950
TLNVYLHTGN FSAMQLLWQR NGNKGSTWMI GQTPITSSVK YQVVFEGIRG
1960 1970 1980 1990 2000
NSFTGDIALD DISFTVGAAN CIQRPYDSLP PGVTTSAPTL STSSSVAPTT
2010 2020 2030 2040 2050
IGNIGNDCNF DVGICKWTFA SYGQFNWTRH QGSTASSGTG PKYDHTRGNS
2060 2070 2080 2090 2100
GQGYYMYIET SVPRRPNDTA GLVSPKVQKV GSFACVIFWY HMFGPHINQL
2110 2120 2130 2140 2150
NVYFKDGSKA KTLMWQKIGS QADEWRQGLL QLSPSQGSYQ VIFEGVRGTS
2160 2170 2180 2190 2200
YQGDISLDDI SFQNNKCPSS TDCTFEYFLG SISNTCGWTQ DGSDDFDWTR
2210 2220 2230 2240 2250
TSGGTPSHAT GPSADHTYGT SQGYYMHIET SYPRRRGDKA RLISPVYRPV
2260 2270 2280 2290 2300
RGGQCFQFWY HMYGSDIDRL NVYIKTGSNI SIPVWSRSGN RGDLWKISQV
2310 2320 2330 2340 2350
PVTTTVNFNI VIEGIAGRSF RGDIAIDDLK LIKSPCPLPG DCDFESGMCT
2360 2370 2380 2390 2400
YDNTQAEDQF DWLRNAGATP SWRTGPSVDH TLGTGFGHYM YIETSSPRRQ
2410 2420 2430 2440 2450
GDKARLMSED FNPTTSSGRC VRFWYHLYGN AIGTLRVLVK TGPGNQSETA
2460 2470 2480 2490 2500
IWELSGNFGN QWYSAQAPVS SAKVYQVVFE GVRGRGVSGD IAIDDITFAT
2510 2520 2530 2540 2550
TRCSVVPSLA VPPTPPPTTP PPVINNCTFE GGFCSWKNLR GDNFDWTRSR
2560 2570 2580 2590 2600
GATSSWRTGP TTDHTLGTRA GYYVYIETSF PRRSKDKAWL QSGLIQPTTV
2610 2620 2630 2640 2650
TNGRCLKFWY HMWGTHVDTL NVYRKVGSSP NVRIWFRRGT QGNKWRFAQV
2660 2670 2680 2690 2700
NLLSNQPFYV IFEGVRGLSY QGDIALDDLD IADGPCPPLT VCDFETDMCK
2710 2720 2730 2740 2750
WTNIAIGDQF DWKRDSGGTP SAGTGPSRDH TTGTRNGMYM YIETSLPRRQ
2760 2770 2780 2790 2800
GDKAYFISPR YDAAPNGKCF KFWYHMYGRH IGKLNIYVKA GPALGAMVWN
2810 2820 2830 2840 2850
ETGNQGNFWL HGKAPVKIST QFQIVIEGIR GASYAGDIAL DDFSLDDSPC
2860 2870 2880 2890 2900
PPEGSCDFEE KSFCSWLNVP NGNKSLGLDD FDWTLGSGST PSWQTGPSTD
2910 2920 2930 2940 2950
HTTGSSLGTY AFIETSNPRR AGHIARIRSK TFSATNGKCM SWWLHMYGRS
2960 2970 2980 2990 3000
VGSLNVYIKK GGSPESLLWN TKGNQGNVWK KTEVTITSKS DFQIIFEGVS
3010 3020 3030 3040 3050
GAGFQGDIAI DDIDFADKYC VGLCSSVNPQ QRVDCSGGLG ISKTTCVNLR
3060 3070 3080 3090 3100
RCCWDDSVPN VPVCFYHPSA CASVIPANRR TCGFSGISSS QCRTRGCCWD
3110 3120 3130 3140 3150
NSLSNVPWCF HGPARPTDFP TQPPPPTTLP PSKWDCTFES GFCNWNNSQE
3160 3170 3180 3190 3200
DDFNWSRQSG GSPSIGTGPT SDHTTGSLRG YYVYIETSYG SANDTAVLES
3210 3220 3230 3240 3250
AMVPATIRKP SGMICLQFWY HMRGQHVDTL NVFVKPGNQL PSSPTWTKSG
3260 3270 3280 3290 3300
TQGTQWRLGQ VAVSSRAPFQ FVFQGIRGKG YQGDIALDDI RVLDGTCPPS
3310 3320 3330 3340 3350
RECDFESPNL CNFTQDTGDI FDWSRGSGNT ISVGTGPSYD HTYKTASGYY
3360 3370 3380 3390 3400
MYIETSAPRR TGDYARIESI SYDQTVGNGR CLVFWHHMYG GGIGRLNVYI
3410 3420 3430 3440 3450
KRGNSLGTPV WRKNGNHGNK WWRGMVTVRS PNQKWKVVFE GIRGRGGRGD
3460 3470 3480 3490 3500
IAIDDIIVKD QPCPPPGSCD FESGWCAYQN DLTGDDFDWE RNTGHTSSIG
3510 3520 3530 3540 3550
TGPSVDHTTG SPQGHYVYIE SSYPRTKGDV ARLTSDLFEV SKGYAWCLSF
3560 3570 3580 3590 3600
WYHMYGNSVG SLSVKITIYP FRKDKPYTRL LWTQQLNHGD VWLTDTVQIN
3610 3620 3630 3640 3650
SPDDFEIVFE AVVGSSYDAD IAIDDIVVTA GFCPSPKPTV APNPCAVRCK
3660 3670 3680 3690 3700
SNNKCVSSTQ LCDFVNDCGR GDNSDEKNCG ACTFEQDLCG WNDTSKGAFK
3710 3720 3730 3740 3750
WNKDRGGTPS SNTGPTIDHT LGTALGYYMY VEASQGRIRD MAQLESPWLK
3760 3770 3780 3790 3800
QSASTCVVSF WYHMYGRGIG TLYGYIKVGL TYTRLFQQSG NKGNNWLQGK
3810 3820 3830 3840 3850
LYVGRRFAPF KIIFEAERSY NVFGDVAVDD VSFVNCTLPP IVSSCGQQHR
3860 3870 3880 3890 3900
CIRGSCIDRG RVCDYTDDCG DNSDEQNCYN FKYRCSFEKS LCQWTQLKDE
3910 3920 3930 3940 3950
EFDWTRNQGV TASYNTGPMF DHTLGTAAGY YLYAEASYPR KKGDKARLAS
3960 3970 3980 3990 4000
GFITTPGDDS CKLRLYFHMF GSGIGSLNVY TRPCNGCAET LVYTRSGNLG
4010 4020 4030 4040 4050
NFWERAEIAL MSRVPFQVII ESVRGVSYLG DIAIDDLSMT SSCQSYRGPL
4060 4070 4080 4090 4100
PTAPPPTTAI PTPPPCPRFQ FKCSNGLCID TWNVCNYRDD CGDGSDEVNC
4110 4120 4130 4140 4150
GSCSFEPGLC GYQDVSLTLY QWSRNRGTTV VPRTGPSVDH TCGNASCFYA
4160 4170 4180 4190 4200
YVHSGAGSFF DDAILQSRNM TKTGPGCVVS FYYHMYSRLS AGFTGTLYLR
4210 4220 4230 4240 4250
LKYKGTTSNL FEVYGNNGDK WKRAEVGLGS LDAGFSIQFV ASKFVTAADI
4260 4270 4280 4290 4300
AVDDVTFQGC ALPPIRSCIS GEYRCTRGSC VLPSQLCDFS DDCGDMSDEN
4310 4320 4330 4340 4350
PSTCASYKER CNFEQDLCSW TQDTDDDFDW TKDSGGTPSS WTGPGRDHTK
4360 4370 4380 4390 4400
GSSKGFYMYI ETSSPRKSNE SARMSSMTFR PSSRNDSCYM RFWYHMFGKD
4410 4420 4430 4440 4450
VDTLSIKLRI SMIGPLIPLW NRTGEQGDMW RRAEIHLASN VNFQVVIEGL
4460 4470 4480 4490 4500
SGPGFQGDIA IDDVSFTPNC RPDSTASIST TIPTGPPIPG CQPGKFKCAN
4510 4520 4530 4540 4550
GGNCISVSKV CNFYSDCSGG SDEMNCPATC NFQNSFCKWQ NAKSVDHYDW
4560 4570 4580 4590 4600
VRNKGQTPSR FTGPSVDHTT NSSAGYYIYT EVSNRTGFFA DAHLVSPLFR
4610 4620 4630 4640 4650
QAGKNCQFKF WYHMFGPNIG FLQVFYRRNS RDQQLFSVFG NKGNKWNQGT
4660 4670 4680 4690 4700
VDIPKCANDF RIVIMAKHYS GGALGDIAVD DVSFEHCAES PPSQTCSGLS
4710 4720 4730 4740 4750
VFRCQSGHCI AMSGKCDFEP DCCDGSEETN IVCAKYNRCN FEAGLCDWTQ
4760 4770 4780 4790 4800
LANDTFNWRM QSGRTGSHRT GPSLDHTTRS RNGRYMYIEA SSPRKPGDSA
4810 4820 4830 4840 4850
ILGSAVFKPT GSCKLRFFYH MYGSHIGHLN VSIRTSTNGP STVLWTKSGD
4860 4870 4880 4890 4900
QGDKWTRATV SISVSKNFQV LIEGVVGSSY RGDIAIDDIS FTPDCVVGGT
4910 4920 4930 4940 4950
IPGLPPPPPT PTQPSCFNCR DGSACVNISK TCDFHNDCTD KSDEDADLCG
4960 4970 4980 4990 5000
WPCDFQRGTC SWTNSNRDNF DWTRHKGCTA SVSTGPCVDA DNRTSGYYMY
5010 5020 5030 5040 5050
IETSTGLIGN KAVLVSPRYQ QAYSTAQLSF WYHMYGRTIG RLSVYLNDGI
5060 5070 5080 5090 5100
NRTRMWTLYG NQGDQWYQTF ISLGRRRTPF TIEFEALRGS SWSGDIAIDS
5110 5120 5130 5140
ISMNNYTLTY CSGQLPPTKW RCRNGACVDA NALCDFSDDC GDNSD
Length:5,145
Mass (Da):570,249
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DD7A2727AB78AB7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Curated1
Non-terminal residuei5145Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
JT011118 mRNA No translation available.

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JT011118 mRNA No translation available.

3D structure databases

SMRiB3EWZ5
ModBaseiSearch...

Proteomic databases

PRIDEiB3EWZ5

Family and domain databases

CDDicd00112, LDLa, 8 hits
cd06263, MAM, 27 hits
cd00111, Trefoil, 2 hits
Gene3Di4.10.400.10, 8 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR000998, MAM_dom
IPR017994, P_trefoil_chordata
IPR017957, P_trefoil_CS
IPR000519, P_trefoil_dom
IPR035992, Ricin_B-like_lectins
PfamiView protein in Pfam
PF00057, Ldl_recept_a, 4 hits
PF00629, MAM, 27 hits
PF00088, Trefoil, 2 hits
PRINTSiPR00261, LDLRECEPTOR
PR00020, MAMDOMAIN
PR00680, PTREFOIL
SMARTiView protein in SMART
SM00192, LDLa, 8 hits
SM00137, MAM, 26 hits
SM00018, PD, 2 hits
SUPFAMiSSF49899, SSF49899, 28 hits
SSF50370, SSF50370, 1 hit
SSF57424, SSF57424, 7 hits
PROSITEiView protein in PROSITE
PS01209, LDLRA_1, 6 hits
PS50068, LDLRA_2, 7 hits
PS00740, MAM_1, 2 hits
PS50060, MAM_2, 27 hits
PS00025, P_TREFOIL_1, 1 hit
PS51448, P_TREFOIL_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLRP1_ACRMI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3EWZ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: July 9, 2014
Last modified: September 29, 2021
This is version 20 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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