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Entry version 19 (07 Oct 2020)
Sequence version 1 (09 Jul 2014)
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Protein

Mucin-like protein

Gene
N/A
Organism
Acropora millepora (Staghorn coral) (Heteropora millepora)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mucin-like protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcropora millepora (Staghorn coral) (Heteropora millepora)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri45264 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaScleractiniaAstrocoeniinaAcroporidaeAcropora

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini‹1 – 1530ExtracellularSequence analysisAdd BLAST›1530
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1531 – 1551HelicalSequence analysisAdd BLAST21
Topological domaini1552 – 1593CytoplasmicSequence analysisAdd BLAST42

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000429549‹1 – 1594Mucin-like proteinAdd BLAST›1594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi153 ↔ 190Sequence analysis
Disulfide bondi157 ↔ 195Sequence analysis
Disulfide bondi168 ↔ 180Sequence analysis
Disulfide bondi210 ↔ 247Sequence analysis
Disulfide bondi214 ↔ 252Sequence analysis
Disulfide bondi225 ↔ 237Sequence analysis
Disulfide bondi267 ↔ 304Sequence analysis
Disulfide bondi271 ↔ 309Sequence analysis
Disulfide bondi282 ↔ 294Sequence analysis
Disulfide bondi1067 ↔ 1075Sequence analysis
Disulfide bondi1069 ↔ 1096Sequence analysis
Disulfide bondi1098 ↔ 1107Sequence analysis
Disulfide bondi1114 ↔ 1127Sequence analysis
Disulfide bondi1121 ↔ 1141Sequence analysis
Disulfide bondi1144 ↔ 1155Sequence analysis
Disulfide bondi1161 ↔ 1173Sequence analysis
Disulfide bondi1169 ↔ 1182Sequence analysis
Disulfide bondi1285 ↔ 1296Sequence analysis
Disulfide bondi1292 ↔ 1305Sequence analysis
Disulfide bondi1307 ↔ 1320Sequence analysis
Disulfide bondi1326 ↔ 1341Sequence analysis
Disulfide bondi1334 ↔ 1350Sequence analysis
Disulfide bondi1352 ↔ 1363Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
B3EWY9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Component of the acid-insoluble and acid-soluble organic matrix of the aragonitic skeleton (at protein level).1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B3EWY9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini141 – 196TSP type-1 1PROSITE-ProRule annotationAdd BLAST56
Domaini198 – 253TSP type-1 2PROSITE-ProRule annotationAdd BLAST56
Domaini255 – 310TSP type-1 3PROSITE-ProRule annotationAdd BLAST56
Domaini400 – 566NIDOPROSITE-ProRule annotationAdd BLAST167
Domaini568 – 706AMOPPROSITE-ProRule annotationAdd BLAST139
Domaini707 – 933VWFDPROSITE-ProRule annotationAdd BLAST227
Domaini1063 – 1108EGF-like 1PROSITE-ProRule annotationAdd BLAST46
Domaini1110 – 1156EGF-like 2PROSITE-ProRule annotationAdd BLAST47
Domaini1157 – 1191EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST35
Domaini1281 – 1321EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini1322 – 1364EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005533, AMOP_dom
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR003886, NIDO_dom
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR001846, VWF_type-D

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12662, cEGF, 3 hits
PF06119, NIDO, 1 hit
PF00090, TSP_1, 3 hits
PF00094, VWD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 7 hits
SM00179, EGF_CA, 6 hits
SM00539, NIDO, 1 hit
SM00209, TSP1, 3 hits
SM00216, VWD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 2 hits
SSF82895, SSF82895, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50856, AMOP, 1 hit
PS00010, ASX_HYDROXYL, 3 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 4 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 3 hits
PS51220, NIDO, 1 hit
PS50092, TSP1, 3 hits
PS51233, VWFD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

B3EWY9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DTTAGPDTTS APQPTTPTGL CGFIRRQPLP EDNLNALNFT LSNFTVERWC
60 70 80 90 100
AREPEFKQFL AQSVSDRCFG NGSCGVESGI PEVFIFPGFP VVNSPLLVRF
110 120 130 140 150
YVRLQVNSSV SVVLERTVLT SILDRVLENL TAEFGVQFSV DGGFTEWSPF
160 170 180 190 200
GPCSTSCGPG IQVRFRNCTN PPPINNGSDC VGPRNETRPC NNGSCPIDGN
210 220 230 240 250
FTQWEIWSGC SVTCGKGVQR RFRSCTKPPP SNGGQDCIGD RLETRECLKP
260 270 280 290 300
PCPVDGNFTE WGAWSKCSQT CENGTQVRFR SCTNPPPAFG GRDCMGPTNE
310 320 330 340 350
TRACNDGPCP GRLYPHGLLA NDNLLPNRDA FSNFCGRINL FNQEIPFFIR
360 370 380 390 400
RHRRVYICRN GMLKFRRSAI IRYPQRFPGP RNEDFLFRFR NSYIIAPYWL
410 420 430 440 450
TISDDAFEQP INTSKVFYRI YSKFSRRDRD VLDRANHDVR RFQTSVPQFE
460 470 480 490 500
AQWVLVVTWL QLYPPTFPGV RLSNSFQVVL ITDGQHTFSL FNYPENGIQW
510 520 530 540 550
STPTGRLFPN LYPPGSGLPV AGYNAGDRNL PFFNLPNSGT VNIQNIDQMM
560 570 580 590 600
GNTNLTGVWF FRLEMNSILS LAGKKCNEWS RQRTSRISPT LPPCPCLFGQ
610 620 630 640 650
ATLDKRYFVD YNQTVSKRGN GTICAYSLPS GSRRWVQQCC YTDLPSGGKV
660 670 680 690 700
LSSSPPESGG PYLIALPGSP VISDADGHEF CCSSSQCSLY YRLRPPRSCF
710 720 730 740 750
GYTLRRRGLI FGDPHFTTLD NTTYTFNGLG EYTIVAIDDE AFEMQARTAR
760 770 780 790 800
TSGRGLGTAF SAAVAKERGT ATVEARINQK AGDLEVLIAG KPFNISTITT
810 820 830 840 850
TGTNIPDGNI TLVRDSNGSI TALFPSNIAF TFTDVEGTLA IAFEAPDDFK
860 870 880 890 900
NRTKGLLGTW NDDPSDDFVT PDGTLVPADA APRRIHYEFG LKWQINASQS
910 920 930 940 950
LFTYSDLESP STFVDLSYIP MFIDNITWVN DSFRYEAVKA CGNNTQCLFD
960 970 980 990 1000
AAVTEDTSYG INTKKLEDNN NEINKELANF PPKILGPKVI NATIGQAIEV
1010 1020 1030 1040 1050
KITAEHNSSD FFVFTVNNLP DVIILANTSR YLLIRWTPTS LQKVEPVFIV
1060 1070 1080 1090 1100
TDSHNSSSEL RPLILLCPCA NGSRCIDDEE VSNQRNKGFS FLLLSCTCPA
1110 1120 1130 1140 1150
GLTGQYCQHK IDACVENNQP CFPGVKCTDV SSSSNGTRYQ CDPCPKGYSG
1160 1170 1180 1190 1200
NGSICEDIDE CSDANVSKCD HSCINLPGSY VCDCNQGFSL EGDGTSCKDI
1210 1220 1230 1240 1250
NECLISNDCM QNCTNLPGGR TCSCLDGFQI DPKDQTACVP ISRCDTFKVG
1260 1270 1280 1290 1300
CQQVCVMDRG QPKCACHKGY SLNADGRTCD DINECTTHRH KCSQICHNLD
1310 1320 1330 1340 1350
GSYTCSCQPG FNLSPDQTTC EDIDECGLIN EAHCEGSLEI CINTMGSFRC
1360 1370 1380 1390 1400
ECQDGFHRVN DTCQESLPST NGPTGTTGIV ASSVSIALTI KDADLHEWQA
1410 1420 1430 1440 1450
RLSRMFMDAV AKVVVDYCKG NANGNCYGNA VIAKRYTRSI SGTSLVARVH
1460 1470 1480 1490 1500
ILNDFPETRD ANLLVAFYVM LSTNQGEVYV MNKDSLLRAL QESQTELSWA
1510 1520 1530 1540 1550
IKKEISEIRA LKVDDESPTP YETREDGLEM IWLLVGVSVA VAVPLMIVIV
1560 1570 1580 1590
ILYREYRRIA KQRRKTNNFD LRQWSGARER TIYSGFTNSK SARL
Length:1,594
Mass (Da):176,622
Last modified:July 9, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA080A39BA586CFF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JR987773 mRNA No translation available.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JR987773 mRNA No translation available.

3D structure databases

SMRiB3EWY9
ModBaseiSearch...

Proteomic databases

PRIDEiB3EWY9

Family and domain databases

Gene3Di2.20.100.10, 3 hits
InterProiView protein in InterPro
IPR005533, AMOP_dom
IPR026823, cEGF
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR003886, NIDO_dom
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
IPR001846, VWF_type-D
PfamiView protein in Pfam
PF12662, cEGF, 3 hits
PF06119, NIDO, 1 hit
PF00090, TSP_1, 3 hits
PF00094, VWD, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 7 hits
SM00179, EGF_CA, 6 hits
SM00539, NIDO, 1 hit
SM00209, TSP1, 3 hits
SM00216, VWD, 1 hit
SUPFAMiSSF57184, SSF57184, 2 hits
SSF82895, SSF82895, 3 hits
PROSITEiView protein in PROSITE
PS50856, AMOP, 1 hit
PS00010, ASX_HYDROXYL, 3 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 4 hits
PS50026, EGF_3, 5 hits
PS01187, EGF_CA, 3 hits
PS51220, NIDO, 1 hit
PS50092, TSP1, 3 hits
PS51233, VWFD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLP_ACRMI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3EWY9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: July 9, 2014
Last modified: October 7, 2020
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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