UniProtKB - B3EWX9 (KAX9B_MESGB)
Protein
Potassium channel toxin alpha-KTx 9.11
Gene
N/A
Organism
Mesobuthus gibbosus (Mediterranean checkered scorpion) (Buthus gibbosus)
Status
Functioni
May play a role in blocking voltage-gated potassium channels Kv1.2/KCNA2, Kv1.3/KCNA3 and Kv1.6/KCNA6 to a lesser extent.1 Publication
Miscellaneous
Has no effect on rat Kv1.1/KCNA1, Kv1.4/KCNA4 and Kv1.5/KCNA5 voltage-gated potassium channels.1 Publication
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel impairing toxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Potassium channel toxin alpha-KTx 9.11By similarityAlternative name(s): Toxin MegKTx2 |
Organismi | Mesobuthus gibbosus (Mediterranean checkered scorpion) (Buthus gibbosus) |
Taxonomic identifieri | 123226 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Mesobuthus |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PeptideiPRO_0000421237 | 1 – 27 | Potassium channel toxin alpha-KTx 9.111 PublicationAdd BLAST | 27 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 3 ↔ 19 | By similarity | ||
Disulfide bondi | 6 ↔ 23 | By similarity | ||
Disulfide bondi | 10 ↔ 25 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.1 Publication
Family & Domainsi
Sequence similaritiesi
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 09 subfamily.Sequence analysis
Family and domain databases
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR008911 Toxin_alpha-KTx_8/9 |
Pfami | View protein in Pfam PF05453 Toxin_6, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
i Sequence
Sequence statusi: Complete.
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | B3EWX9 |
ModBasei | Search... |
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR036574 Scorpion_toxin-like_sf IPR008911 Toxin_alpha-KTx_8/9 |
Pfami | View protein in Pfam PF05453 Toxin_6, 1 hit |
SUPFAMi | SSF57095 SSF57095, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | KAX9B_MESGB | |
Accessioni | B3EWX9Primary (citable) accession number: B3EWX9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2013 |
Last sequence update: | February 6, 2013 | |
Last modified: | December 5, 2018 | |
This is version 19 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- Scorpion potassium channel toxins
Nomenclature of scorpion potassium channel toxins and list of entries - SIMILARITY comments
Index of protein domains and families