UniProtKB - B3EWN3 (HTX2_CYRLI)
Protein
Beta/kappa-theraphotoxin-Hlv1a
Gene
N/A
Organism
Cyriopagopus lividus (Cobalt blue tarantula) (Haplopelma lividum)
Status
Functioni
Spider venom neurotoxin that blocks voltage-gated sodium channel Nav1.3/SCN3A in human (IC50=80 nM) and rat (IC50=160 nM). Partially inhibits human Kv11.1/KCNH2/ERG (25% at 175 µM).1 Publication
Miscellaneous
Has no effect on human and rat Nav1.8/SCN10A (Ref. 1).
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- pathogenesis Source: InterPro
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin, Voltage-gated sodium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Beta/kappa-theraphotoxin-Hlv1aShort name: Beta/kappa-TRTX-Hlv1a Alternative name(s): Beta/kappa-theraphotoxin-Hl2a1 Publication Short name: Beta/kappa-TRTX-Hl2a1 Publication Haplotoxin-21 Publication |
Organismi | Cyriopagopus lividus (Cobalt blue tarantula) (Haplopelma lividum) |
Taxonomic identifieri | 1184493 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Chelicerata › Arachnida › Araneae › Mygalomorphae › Theraphosidae › Haplopelma |
Organism-specific databases
ArachnoServeri | AS001561, beta/kappa-theraphotoxin-Hlv1a |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000419140 | 1 – 33 | Beta/kappa-theraphotoxin-Hlv1aAdd BLAST | 33 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 2 ↔ 17 | By similarity | ||
Disulfide bondi | 9 ↔ 22 | By similarity | ||
Disulfide bondi | 16 ↔ 29 | By similarity | ||
Modified residuei | 33 | Isoleucine amide1 Publication | 1 |
Keywords - PTMi
Amidation, Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.Curated
Family & Domainsi
Domaini
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity
Sequence similaritiesi
Keywords - Domaini
KnottinFamily and domain databases
InterProi | View protein in InterPro IPR011696, Huwentoxin-1 IPR013140, Huwentoxin_CS1 |
Pfami | View protein in Pfam PF07740, Toxin_12, 1 hit |
PROSITEi | View protein in PROSITE PS60021, HWTX_1, 1 hit |
i Sequence
Sequence statusi: Complete.
Mass spectrometryi
Molecular mass is 3705.6 Da. Determined by MALDI. 1 Publication
Similar proteinsi
Cross-referencesi
3D structure databases
SMRi | B3EWN3 |
ModBasei | Search... |
Organism-specific databases
ArachnoServeri | AS001561, beta/kappa-theraphotoxin-Hlv1a |
Family and domain databases
InterProi | View protein in InterPro IPR011696, Huwentoxin-1 IPR013140, Huwentoxin_CS1 |
Pfami | View protein in Pfam PF07740, Toxin_12, 1 hit |
PROSITEi | View protein in PROSITE PS60021, HWTX_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HTX2_CYRLI | |
Accessioni | B3EWN3Primary (citable) accession number: B3EWN3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2012 |
Last sequence update: | September 5, 2012 | |
Last modified: | December 11, 2019 | |
This is version 17 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families