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Protein

Argininosuccinate lyase

Gene

argH

Organism
Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciGLOV398767:G1GC4-3144-MONOMER
UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:Glov_3145
OrganismiGeobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Taxonomic identifieri398767 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000002420 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000890841 – 458Argininosuccinate lyaseAdd BLAST458

Interactioni

Protein-protein interaction databases

STRINGi398767.Glov_3145

Structurei

3D structure databases

ProteinModelPortaliB3E9X6
SMRiB3E9X6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG091H026A

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

B3E9X6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQNKLWGGR FTQPTDKFVE EFTASIDFDK RLYHQDIRGS VAHARMLGRQ
60 70 80 90 100
GIIPQQDVEQ IVHGLKDILA QIEAGQFDFS VGLEDIHMNI EARLSQKIGE
110 120 130 140 150
AGKRLHTGRS RNDQVALDIR LYLRDEIVEV VAYLDMLIDS LLEQAEKNLE
160 170 180 190 200
VVMPGFTHLQ SAQPILFSHH MLAYVEMFKR DKGRMDDCLK RVNVLPLGAG
210 220 230 240 250
ALAGTTFPID REYVAEQLDF PAVTRNSLDS VSDRDFALEF IAASSILMMH
260 270 280 290 300
LSRLSEELII WSTSAFRFVD LSDGFCTGSS IMPQKKNPDV PELVRGKTGR
310 320 330 340 350
VYGNLMALLT VMKALPLAYN KDMQEDKEPL FDTIDTVKGS LKIFADMIRE
360 370 380 390 400
MRVNSSSMGR AAGQGFSTAT DVADYLVRKG LPFRDAHEAV GKAVAYCVEN
410 420 430 440 450
EMDIIDLSLA EWQLFSPHFS DDIFAAITVE ASVNARDVIG GTARNRVEDE

IRRCREGK
Length:458
Mass (Da):51,375
Last modified:July 22, 2008 - v1
Checksum:i796C8B2B034563DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001089 Genomic DNA Translation: ACD96851.1
RefSeqiWP_012471175.1, NC_010814.1

Genome annotation databases

EnsemblBacteriaiACD96851; ACD96851; Glov_3145
KEGGiglo:Glov_3145

Similar proteinsi

Entry informationi

Entry nameiARLY_GEOLS
AccessioniPrimary (citable) accession number: B3E9X6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: February 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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