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Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. LL-diaminopimelate aminotransferase (dapL)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15SubstrateUniRule annotation1
Binding sitei42Substrate; via amide nitrogenUniRule annotation1
Binding sitei72Pyridoxal phosphateUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei132Pyridoxal phosphateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Binding sitei187Pyridoxal phosphateUniRule annotation1
Binding sitei187SubstrateUniRule annotation1
Binding sitei218Pyridoxal phosphateUniRule annotation1
Binding sitei257Pyridoxal phosphateUniRule annotation1
Binding sitei292Pyridoxal phosphateUniRule annotation1
Binding sitei292SubstrateUniRule annotation1
Binding sitei388SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciGLOV398767:G1GC4-3037-MONOMER
UniPathwayi
UPA00034;UER00466

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-ATUniRule annotation
Short name:
DAP-aminotransferaseUniRule annotation
Short name:
LL-DAP-aminotransferaseUniRule annotation
Gene namesi
Name:dapLUniRule annotation
Ordered Locus Names:Glov_3040
OrganismiGeobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Taxonomic identifieri398767 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000002420 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001868681 – 410LL-diaminopimelate aminotransferaseAdd BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei249N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiB3E933

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi398767.Glov_3040

Structurei

3D structure databases

ProteinModelPortaliB3E933
SMRiB3E933
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 109Pyridoxal phosphate bindingUniRule annotation2
Regioni246 – 248Pyridoxal phosphate bindingUniRule annotation3

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107QSS Bacteria
COG0436 LUCA
HOGENOMiHOG000223061
KOiK10206
OMAiTGTRCAF
OrthoDBiPOG091H0235

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019942 DapL/ALD1
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43144 PTHR43144, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03542 DAPAT_plant, 1 hit

Sequencei

Sequence statusi: Complete.

B3E933-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKINDNYLK LKAGYLFPEI GRRVREFTAA NPSAKVIRLG IGDVTRPLAP
60 70 80 90 100
TVLKAFHAAV DDLATTDQFA GYGPEQGYDW LINAIIEKSY KPLGVDLKTE
110 120 130 140 150
EMFISDGSKC DCANILDIFA LDNVVAIGDP VYPVYNDTNV MIGRTGEADE
160 170 180 190 200
KGYYQNIVYL PCNEANNFIP SLPTQKVDII YLCFPNNPTG TVASKAELKK
210 220 230 240 250
WIDYANANDA IIFFDAAYEA FITNPEIPHS IYEIEGAKKC AIEFRSFSKT
260 270 280 290 300
AGFTGVRCGL VVVPEEVMGT TASGEKYSFN KLWLRRTTTK FNGASYPVQR
310 320 330 340 350
AAAAVYSEEG WKQTKEIIDY YMENARIIRE GLKEVGVTCY GGVDAPYIWL
360 370 380 390 400
KTPGGMSSWD FFDKLLNECN VVGTPGSGFG PSGEGFFRLS AFGHRENVIE
410
AVERIKKNLK
Length:410
Mass (Da):45,438
Last modified:July 22, 2008 - v1
Checksum:i25E702C5615581C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001089 Genomic DNA Translation: ACD96746.1
RefSeqiWP_012471071.1, NC_010814.1

Genome annotation databases

EnsemblBacteriaiACD96746; ACD96746; Glov_3040
KEGGiglo:Glov_3040

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001089 Genomic DNA Translation: ACD96746.1
RefSeqiWP_012471071.1, NC_010814.1

3D structure databases

ProteinModelPortaliB3E933
SMRiB3E933
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi398767.Glov_3040

Proteomic databases

PRIDEiB3E933

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD96746; ACD96746; Glov_3040
KEGGiglo:Glov_3040

Phylogenomic databases

eggNOGiENOG4107QSS Bacteria
COG0436 LUCA
HOGENOMiHOG000223061
KOiK10206
OMAiTGTRCAF
OrthoDBiPOG091H0235

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00466

BioCyciGLOV398767:G1GC4-3037-MONOMER

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019942 DapL/ALD1
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43144 PTHR43144, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03542 DAPAT_plant, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDAPAT_GEOLS
AccessioniPrimary (citable) accession number: B3E933
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 22, 2008
Last modified: October 10, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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