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Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

Activity regulationi

Allosterically activated by GTP.UniRule annotation

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uracil.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Uracil phosphoribosyltransferase (upp)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uracil, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei785-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1
Binding sitei1035-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1
Binding sitei193Uracil; via amide nitrogenUniRule annotation1
Binding sitei1995-phospho-alpha-D-ribose 1-diphosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Glycosyltransferase, Transferase
LigandGTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciGLOV398767:G1GC4-1071-MONOMER
UniPathwayi
UPA00574;UER00636

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Alternative name(s):
UMP pyrophosphorylaseUniRule annotation
UPRTaseUniRule annotation
Gene namesi
Name:uppUniRule annotation
Ordered Locus Names:Glov_1078
OrganismiGeobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ)
Taxonomic identifieri398767 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000002420 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001391311 – 208Uracil phosphoribosyltransferaseAdd BLAST208

Proteomic databases

PRIDEiB3E677

Interactioni

Protein-protein interaction databases

STRINGi398767.Glov_1078

Structurei

3D structure databases

ProteinModelPortaliB3E677
SMRiB3E677
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni130 – 1385-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation9
Regioni198 – 200Uracil bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ5 Bacteria
COG0035 LUCA
HOGENOMiHOG000262754
KOiK00761
OMAiRICGYEI
OrthoDBiPOG091H02GN

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01218_B Upp_B, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR034332 Upp_B
IPR005765 Ura_phspho_trans
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01091 upp, 1 hit

Sequencei

Sequence statusi: Complete.

B3E677-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIYEVKHPL IQHKLGLLRK ADLSTKQFRE LASEVARLLT YEATKDLETE
60 70 80 90 100
SITINGWAGP VTVQQIKGKK ITIVPILRAG LGMMNGVLDM IPSAKVSVVG
110 120 130 140 150
LYRNEETLEP VAYYEKFTTD MEERTALIID PMLATGGSLL ATIEMLKATG
160 170 180 190 200
CRRIKGLFLV AVPEGLEKIS SAHPDVEIYV ASIDERLNEH GYILPGLGDA

GDKIFGTK
Length:208
Mass (Da):22,826
Last modified:July 22, 2008 - v1
Checksum:i34FCC07D7FC3B1E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001089 Genomic DNA Translation: ACD94801.1
RefSeqiWP_012469151.1, NC_010814.1

Genome annotation databases

EnsemblBacteriaiACD94801; ACD94801; Glov_1078
KEGGiglo:Glov_1078

Similar proteinsi

Entry informationi

Entry nameiUPP_GEOLS
AccessioniPrimary (citable) accession number: B3E677
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: September 12, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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