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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Bifidobacterium longum (strain DJO10A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi521MagnesiumUniRule annotation1
Metal bindingi527MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:BLD_1664
OrganismiBifidobacterium longum (strain DJO10A)
Taxonomic identifieri205913 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000002419 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001478881 – 913Polyribonucleotide nucleotidyltransferaseAdd BLAST913

Proteomic databases

PRIDEiB3DPX0

Structurei

3D structure databases

ProteinModelPortaliB3DPX0
SMRiB3DPX0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini587 – 646KHUniRule annotationAdd BLAST60
Domaini658 – 730S1 motifUniRule annotationAdd BLAST73

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN

Family and domain databases

Gene3Di3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR036345 ExoRNase_PH_dom2_sf
IPR014069 GPSI/PNP
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF00575 S1, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
TIGR02696 pppGpp_PNP, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

B3DPX0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGPEIKAVE AVIDNGSFGK RTLRFETGRL AQQADGAVAA YLDDDSMILS
60 70 80 90 100
TTTAGSSPKE NYDFFPLTVD VEEKMYAAGK IPGSFFRREG RPSSEAILAC
110 120 130 140 150
RIIDRPLRPL FPHTLRNEVQ VVETVLAVNP DDAYDVIALN AASASTMISG
160 170 180 190 200
LPFEGPVSGV RLALIDGQWV AFPRWSERER AVFEIVVAGR VIENGDVAIA
210 220 230 240 250
MIEAGAGKNA WHLIYDEGQT KPDEEVVAGG LEAAKPFIKV ICEAQDELKK
260 270 280 290 300
IAAKETKEFQ LFPEYTDELY ARIDEIAHKD LDEALSIAEK LPRQDRIHEI
310 320 330 340 350
KEHVREVLAD EFTDMDDAEK DKELGNAFKE LQRQIVRRRI LTEDYRIDGR
360 370 380 390 400
GLRDIRTLSA EVDIVPRVHG SALFQRGETQ ILGVTTLNML KMEQQIDALS
410 420 430 440 450
GPQSKRYMHN YEMPPYSTGE TGRVGSPKRR EIGHGALAEK ALVPVLPSRE
460 470 480 490 500
EFPYAIRQVS EAIGSNGSTS MGSVCASTLS LLAAGVPLKA PVAGIAMGLV
510 520 530 540 550
SGDVDGKHIF KTLTDILGAE DAFGDMDFKV AGTSEFITAL QLDTKLDGIP
560 570 580 590 600
ADILAAALQQ AKEARATILE VINECIDGPA EMSEFAPRII TTSVPVEKIG
610 620 630 640 650
EVIGPKGKMI NQIQEDTGAE IAIEDDGTVF ISSEGGEAAE KAKAIIDQIA
660 670 680 690 700
NPHVPEAGET YNGKVVKTTS FGAFVNLTPG TDGLLHISQI RNLANGERID
710 720 730 740 750
AVEDVLKEGD TVEVIVQGVD DRGKISLAIP GFEDQENNAR PSRGDRDDRR
760 770 780 790 800
GGRGRGDRDD RRGGRGRRSE RDDRDFDDRD DRPRRRRSDD FEDDYDDRPR
810 820 830 840 850
RRRSDDRDFD RDDRDDDRPR RRRSADRDFD DRDDRDARDS RDDDRPRRRR
860 870 880 890 900
SSDRDDRGDR DDRRGGSRGR GRGSDRNPRY ATDDNYDDYR ADREERTERP
910
RRRVRRDFDP FED
Length:913
Mass (Da):101,847
Last modified:July 22, 2008 - v1
Checksum:i44BF8295382F2AFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000605 Genomic DNA Translation: ACD99109.1
RefSeqiWP_010081538.1, NZ_AABM02000021.1

Genome annotation databases

EnsemblBacteriaiACD99109; ACD99109; BLD_1664
KEGGiblj:BLD_1664

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000605 Genomic DNA Translation: ACD99109.1
RefSeqiWP_010081538.1, NZ_AABM02000021.1

3D structure databases

ProteinModelPortaliB3DPX0
SMRiB3DPX0
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB3DPX0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACD99109; ACD99109; BLD_1664
KEGGiblj:BLD_1664

Phylogenomic databases

HOGENOMiHOG000218326
KOiK00962
OMAiRYMHNYN

Family and domain databases

Gene3Di3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR036345 ExoRNase_PH_dom2_sf
IPR014069 GPSI/PNP
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR036456 PNPase_PH_RNA-bd_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF00575 S1, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF46915 SSF46915, 1 hit
SSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
TIGR02696 pppGpp_PNP, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPNP_BIFLD
AccessioniPrimary (citable) accession number: B3DPX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: October 10, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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