Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 84 (07 Oct 2020)
Sequence version 1 (22 Jul 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Ataxin 2-like

Gene

Atxn2l

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ataxin 2-likeImported
Submitted name:
Atxn2l proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Atxn2lImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Rat genome database

More...
RGDi
1565868, Atxn2l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
B3DMA1

PRoteomics IDEntifications database

More...
PRIDEi
B3DMA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000018686, Expressed in testis and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000059876

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini262 – 331LsmADInterPro annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 53DisorderedSequence analysisAdd BLAST53
Regioni314 – 515DisorderedSequence analysisAdd BLAST202
Regioni572 – 698DisorderedSequence analysisAdd BLAST127
Regioni730 – 766DisorderedSequence analysisAdd BLAST37
Regioni818 – 847DisorderedSequence analysisAdd BLAST30
Regioni862 – 936DisorderedSequence analysisAdd BLAST75
Regioni1021 – 1041DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi32 – 53Pro-richSequence analysisAdd BLAST22
Compositional biasi314 – 330PolyampholyteSequence analysisAdd BLAST17
Compositional biasi417 – 432PolarSequence analysisAdd BLAST16
Compositional biasi471 – 486PolarSequence analysisAdd BLAST16
Compositional biasi650 – 698PolarSequence analysisAdd BLAST49
Compositional biasi862 – 914PolarSequence analysisAdd BLAST53
Compositional biasi917 – 931Pro-richSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ataxin-2 family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2375, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157795

KEGG Orthology (KO)

More...
KOi
K23625

Database of Orthologous Groups

More...
OrthoDBi
282700at2759

TreeFam database of animal gene trees

More...
TreeFami
TF326591

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009818, Ataxin-2_C
IPR009604, LsmAD_domain
IPR025852, SM_dom_ATX

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06741, LsmAD, 1 hit
PF07145, PAM2, 1 hit
PF14438, SM-ATX, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01272, LsmAD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B3DMA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKPQPPQQT SQPQQPPPTQ QAVARRPPGG TSPPNGGLPG PLPATAAPPG
60 70 80 90 100
PPTVVSPCLG PAAAAGSGLR RGAESILAAP APQQHQERPG AVAIGSVRGQ
110 120 130 140 150
TTGKGPPQSP VFEGVYNNSR MLHFLTAVVG STCDVKVKNG TTYEGIFKTL
160 170 180 190 200
SSKFELAVDA VHRKASEPAG GPRREDIVDT MVFKPSDVLL VHFRNVDFNY
210 220 230 240 250
ATKDKFTDSA IAMNSKVNGE HKEKVLQRWE GGDSNSDDYD LESDMSNGWD
260 270 280 290 300
PNEMFKFNEE NYGVKTTYDS SLSSYTVPLE KDNSEEFRQR ELRAAQLARE
310 320 330 340 350
IESSPQYRLR IAMENDDGRT EEEKHSAVQR QGSGRESPSL VSREGKYIPL
360 370 380 390 400
PQRVREGPRG GVRCSSSRGG RPGLSSLPPR GPHHLDNSSP GPGSEARGIN
410 420 430 440 450
GGPSRMSPKA QRPLRGGKTL SSPNNRPSGE ASVPPTSAVG RMYPPRSPKS
460 470 480 490 500
AAPAPVSASC PEPPIGSAVA SSASIPVTSS VVDPGAGSIS PASPKLSLAP
510 520 530 540 550
TDVKELPTKE PSRSLEAQEL ARIAGKVPGL QNEQKRFQLE ELRKFGAQFK
560 570 580 590 600
LQPSSSSETG LDPFPSRILK EEAKGKEKEV DGLLTSDPMG SPVSSKAESI
610 620 630 640 650
LDKEDKVPLA AVAGSEGPEQ LQPPCPSQTG SPPVGLIKGD DKEEGPVTEQ
660 670 680 690 700
VKKSTLNPNA KEFNPTKPLL SVNKSTSTPT SPGPRTHSTP SIPVLTAGQS
710 720 730 740 750
GLYSPQYISY IPQIHMGPAV QAPQMYPYPV SNSVPGQQGK YRGAKGSLPP
760 770 780 790 800
QRSDQHQPAS APPMMQAAAA AAGPPLVAAT PYSSYIPYNP QQFPGQPAMM
810 820 830 840 850
QPMAHYPSQP VFAPMLQSNP RMLTSGSHPQ AIVSSSTPQY PSAEQPTPQA
860 870 880 890 900
LYATVHQSYP HHATQLHGHQ PQPATTPTGS QPQSQHAAPS PVQAGQAPHL
910 920 930 940 950
GSGQPQQNLY HPGALTGTPP SLPPGPSAQS PQSSFPQPAA VYAIHPHQQL
960 970 980 990 1000
PHGFTNMAHV TQAHVQTGVT AAPPPHPGAP HPPQVMLLHP PQGHGGPPQG
1010 1020 1030 1040 1050
AVPPSGVPAL SASTPSPYPY IGHPQGEQPG QAPGFPGGAD DRIREFSLAG
1060 1070
GIWHGRAEGL QVGQDARVLG GD
Length:1,072
Mass (Da):112,854
Last modified:July 22, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEC9F515718720BBC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JYE0A0A0G2JYE0_RAT
Ataxin 2-like
Atxn2l
1,078Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07005777 Genomic DNA No translation available.
BC167761 mRNA Translation: AAI67761.1

NCBI Reference Sequences

More...
RefSeqi
NP_001123569.2, NM_001130097.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000068529; ENSRNOP00000059876; ENSRNOG00000018686

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
361649

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:361649

UCSC genome browser

More...
UCSCi
RGD:1565868, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07005777 Genomic DNA No translation available.
BC167761 mRNA Translation: AAI67761.1
RefSeqiNP_001123569.2, NM_001130097.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059876

Proteomic databases

jPOSTiB3DMA1
PRIDEiB3DMA1

Genome annotation databases

EnsembliENSRNOT00000068529; ENSRNOP00000059876; ENSRNOG00000018686
GeneIDi361649
KEGGirno:361649
UCSCiRGD:1565868, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11273
RGDi1565868, Atxn2l

Phylogenomic databases

eggNOGiKOG2375, Eukaryota
GeneTreeiENSGT00940000157795
KOiK23625
OrthoDBi282700at2759
TreeFamiTF326591

Gene expression databases

BgeeiENSRNOG00000018686, Expressed in testis and 21 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR009818, Ataxin-2_C
IPR009604, LsmAD_domain
IPR025852, SM_dom_ATX
PfamiView protein in Pfam
PF06741, LsmAD, 1 hit
PF07145, PAM2, 1 hit
PF14438, SM-ATX, 1 hit
SMARTiView protein in SMART
SM01272, LsmAD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3DMA1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3DMA1
Secondary accession number(s): F1LR43
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: October 7, 2020
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again