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Protein

Transcription factor Sox-5

Gene

sox5

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds specifically to the DNA sequence 5'-AACAAT-3'.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi557 – 625HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sox-5By similarity
Alternative name(s):
SRY (sex determining region Y)-box 5
Gene namesi
Name:sox5Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-487032 sox5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003780661 – 753Transcription factor Sox-5Add BLAST753

Proteomic databases

PaxDbiB3DM43
PRIDEiB3DM43

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000055793

Structurei

3D structure databases

SMRiB3DM43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili453 – 487Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi227 – 271Gln-richSequence analysisAdd BLAST45

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0528 Eukaryota
ENOG410YZNG LUCA
InParanoidiB3DM43
KOiK09269

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B3DM43-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTDPDLPPE FERMSSKRPA SPYGEADGEV AMVTSRQKME DDGGDGLPAF
60 70 80 90 100
HLPLHVGFKP HSEEFQAVSL LTQEGCDRRS PSYQHNTMEL DCNKMPPFAL
110 120 130 140 150
HNAATSPIKA EELGRQSGES LANAMLGTPE RRKGSLADVV DTLKQRKMEE
160 170 180 190 200
LIKSEPEETP SIEKLLSKDW KDKLLAMGSG NLGDVKGTPE SLAEKERQLM
210 220 230 240 250
AMINQLTSLR EQLLAAHDEQ KKLAASQIEK QRQQMELAKQ QQEQIARQQQ
260 270 280 290 300
QLLQQQHKIN LLQQQIQVQG QLPPLMIPVF PPDQRTLAAA AAAQQGFLIP
310 320 330 340 350
PGFSYKPGCS DPYPVQLIPT TMAAAAAATP GLAPLQLQQL YAAQLAAMQV
360 370 380 390 400
SPGAKLPGVP PSNLSNAVSP SSIHTDKSTS SPPPKTKDDV TQPLNLSAKP
410 420 430 440 450
KGSDSKSPSS PTSPHIPRLS SALAHKPICS TSASTPLRVN SIDILSSITS
460 470 480 490 500
PGYLNDHDAV TKAIQEARQM KEQLRREQQA LDGKVVNSLG LNNCRTDKDK
510 520 530 540 550
SSLESLTQQL TGKPNEDKFS HAMMDFNLSG DSDGSAGISE SRIYRESRGR
560 570 580 590 600
GSNEPHIKRP MNAFMVWAKD ERRKILQAFP DMHNSNISKI LGSRWKAMTN
610 620 630 640 650
LEKQPYYEEQ ARLSKQHLEK YPDYKYKPRP KRTCLVDGKK LRIGEYKAIM
660 670 680 690 700
RSRRQQAQIP ISTAGVVYPG AIAMAGMPSP HLPSEHSSVS SSPEPGMPVI
710 720 730 740 750
QSTYGIKEEE PHIKEEIHRE DINGEMYDEY DEDDDPDVDY ASDSENLSAE

QAN
Length:753
Mass (Da):83,100
Last modified:July 22, 2008 - v1
Checksum:iCDC07323325AAA8A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7APM5F7APM5_XENTR
Transcription factor Sox-5
sox5
492Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167694 mRNA Translation: AAI67694.1
RefSeqiNP_001122130.1, NM_001128658.1
UniGeneiStr.52388

Genome annotation databases

GeneIDi100038209
KEGGixtr:100038209

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167694 mRNA Translation: AAI67694.1
RefSeqiNP_001122130.1, NM_001128658.1
UniGeneiStr.52388

3D structure databases

SMRiB3DM43
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000055793

Proteomic databases

PaxDbiB3DM43
PRIDEiB3DM43

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100038209
KEGGixtr:100038209

Organism-specific databases

CTDi6660
XenbaseiXB-GENE-487032 sox5

Phylogenomic databases

eggNOGiKOG0528 Eukaryota
ENOG410YZNG LUCA
InParanoidiB3DM43
KOiK09269

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSOX5_XENTR
AccessioniPrimary (citable) accession number: B3DM43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: July 22, 2008
Last modified: October 25, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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