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Protein
Submitted name:

Epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)

Gene

epm2a

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseSAAS annotation

Enzyme and pathway databases

ReactomeiR-XTR-3322077 Glycogen synthesis

Protein family/group databases

CAZyiCBM20 Carbohydrate-Binding Module Family 20

Names & Taxonomyi

Protein namesi
Submitted name:
Epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)Imported
Submitted name:
LOC100170449 proteinImported
Gene namesi
Name:epm2aImported
Synonyms:LOC100170449Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-965638 epm2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneSAAS annotation

Expressioni

Gene expression databases

BgeeiENSXETG00000017691

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000038390

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 113CBM20InterPro annotationAdd BLAST113
Domaini138 – 285Tyrosine-protein phosphataseInterPro annotationAdd BLAST148
Domaini225 – 293TYR_PHOSPHATASE_2InterPro annotationAdd BLAST69

Phylogenomic databases

eggNOGiKOG1716 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00390000010101
HOGENOMiHOG000285975
HOVERGENiHBG051493
KOiK14165
OMAiSWEGNGP
OrthoDBiEOG091G0GBM
TreeFamiTF332841

Family and domain databases

CDDicd05806 CBM20_laforin, 1 hit
Gene3Di2.60.40.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR013784 Carb-bd-like_fold
IPR034831 CBM20_laforin
IPR002044 CBM_fam20
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00686 CBM_20, 1 hit
PF00782 DSPc, 1 hit
SMARTiView protein in SMART
SM01065 CBM_2, 1 hit
SM00195 DSPc, 1 hit
SUPFAMiSSF49452 SSF49452, 1 hit
SSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51166 CBM20, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

B3DL33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFRFGVIIT LNHSDNELLV LGSRKEMGSW DPQYAVPMKP TRCPLSTTEP
60 70 80 90 100
SFWVGEVLLE EPYTDTFWFK FIKKESGALI WEGNGPHHDR CCVFNESNIV
110 120 130 140 150
DGVYCHPVGH WIETTGHTDE MKHTTDFYFH FAGTQAMHFS RILPNIWLGS
160 170 180 190 200
CPRQREHVTV KMKHELGVTA VLNFQTEWDV IQNSSGCNNY PEPMSPETMF
210 220 230 240 250
RLYKEAGITY IWIPTPDMST EGRIRMLPQA VYLLFGLLEN GHTVYVHCNA
260 270 280 290 300
GVGRSTAAVC GFLMYVIGWS LRKVQYFLAS RRPAVYIDEE AMINAQEDFH
310
KKFGHLRSTV CRI
Length:313
Mass (Da):35,982
Last modified:July 22, 2008 - v1
Checksum:i51F67CB470174E74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01033867 Genomic DNA No translation available.
BC167294 mRNA Translation: AAI67294.1
BC167295 mRNA Translation: AAI67295.1
RefSeqiNP_001123695.1, NM_001130223.1
UniGeneiStr.36893

Genome annotation databases

EnsembliENSXETT00000038390; ENSXETP00000038390; ENSXETG00000017691
GeneIDi100170449
KEGGixtr:100170449

Similar proteinsi

Entry informationi

Entry nameiB3DL33_XENTR
AccessioniPrimary (citable) accession number: B3DL33
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 18, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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