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Entry version 69 (07 Apr 2021)
Sequence version 1 (22 Jul 2008)
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Protein

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase

Gene

atic

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route).ARBA annotation This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.ARBA annotation This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseARBA annotation, Multifunctional enzymeARBA annotation, TransferaseARBA annotation
Biological processPurine biosynthesisARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00074;UER00133
UPA00074;UER00135

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferaseARBA annotation (EC:2.1.2.3ARBA annotation, EC:3.5.4.10ARBA annotation)
Alternative name(s):
AICAR transformylaseARBA annotation
AICAR transformylase/inosine monophosphate cyclohydrolaseARBA annotation
Bifunctional purine biosynthesis protein ATICARBA annotation
IMP synthaseARBA annotation
InosinicaseARBA annotation
Phosphoribosylaminoimidazolecarboxamide formyltransferaseARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:aticImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-011212-4, atic

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 145MGS-likeInterPro annotationAdd BLAST145

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PurH family.ARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
WRVAKFV

Database of Orthologous Groups

More...
OrthoDBi
324473at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B3DKL0

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.440, 1 hit
3.40.140.20, 2 hits
3.40.50.1380, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00139, PurH, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024051, AICAR_Tfase_dup_dom_sf
IPR024050, AICAR_Tfase_insert_dom_sf
IPR016193, Cytidine_deaminase-like
IPR011607, MGS-like_dom
IPR036914, MGS-like_dom_sf
IPR002695, PurH-like

The PANTHER Classification System

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PANTHERi
PTHR11692, PTHR11692, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01808, AICARFT_IMPCHas, 1 hit
PF02142, MGS, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000414, AICARFT_IMPCHas, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00798, AICARFT_IMPCHas, 1 hit
SM00851, MGS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52335, SSF52335, 1 hit
SSF53927, SSF53927, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00355, purH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51855, MGS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3DKL0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASEIALLSV SDKTGLVEFA RRLVSVGLSL VASGGTAKTL RDAGLAVRDV
60 70 80 90 100
SEITGFPEML GGRVKTLHPA VHGGILARKT PSDNADMEKL GFSLVRVAVC
110 120 130 140 150
NLYPFVKTVS SPGVTVEDAV EQIDIGGVTL LRAAAKNHAR VTVVCDPSDY
160 170 180 190 200
NVVAKEMETS EIHDTTMETR KTLALKAFTH TAQYDEAISD YFRREYSRGV
210 220 230 240 250
SQLPLRYGMN PHQAPAQLYT TRPALPLAVL NGSPGFINLC DALNAWQLVR
260 270 280 290 300
ELKKALGLPA ATSFKHVSPA GAAVGVPLSE DEAKVCMVND MLQDLTPLAT
310 320 330 340 350
AYARARGSDR MSSFGDFIAL SDVCDVPTAK IISREVSDGI VAPGYEEDAL
360 370 380 390 400
RILSKKKNGN YCVLKMDPEY EPDEEEVRVL FGLHLKQKRN GAVIDKELFS
410 420 430 440 450
NIVSKGKLSE SALRDLIVAS IAVKYTQSNS VCYAKDGQVI GIGAGQQSRI
460 470 480 490 500
HCTRLAGDKA DNWWLRHHPG VLSMRFRSGV KRAEMANAID QYVSGTVGEG
510 520 530 540 550
PDKEVWKGLF EEVPEPLSEV EKKNWISSLQ AVALSSDAFF PFRDNVDRAK
560 570 580 590
QSGVEYIAAP SGSTADEVVV KACNELGITL VHTNIRLFHH
Length:590
Mass (Da):64,044
Last modified:July 22, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5EE4EC9FE83A6D39
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC163887 mRNA Translation: AAI63887.1

NCBI Reference Sequences

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RefSeqi
NP_001076265.2, NM_001082796.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
140622

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:140622

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC163887 mRNA Translation: AAI63887.1
RefSeqiNP_001076265.2, NM_001082796.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi140622
KEGGidre:140622

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
471
ZFINiZDB-GENE-011212-4, atic

Phylogenomic databases

OMAiWRVAKFV
OrthoDBi324473at2759
PhylomeDBiB3DKL0

Enzyme and pathway databases

UniPathwayiUPA00074;UER00133
UPA00074;UER00135

Family and domain databases

Gene3Di1.10.287.440, 1 hit
3.40.140.20, 2 hits
3.40.50.1380, 1 hit
HAMAPiMF_00139, PurH, 1 hit
InterProiView protein in InterPro
IPR024051, AICAR_Tfase_dup_dom_sf
IPR024050, AICAR_Tfase_insert_dom_sf
IPR016193, Cytidine_deaminase-like
IPR011607, MGS-like_dom
IPR036914, MGS-like_dom_sf
IPR002695, PurH-like
PANTHERiPTHR11692, PTHR11692, 1 hit
PfamiView protein in Pfam
PF01808, AICARFT_IMPCHas, 1 hit
PF02142, MGS, 1 hit
PIRSFiPIRSF000414, AICARFT_IMPCHas, 1 hit
SMARTiView protein in SMART
SM00798, AICARFT_IMPCHas, 1 hit
SM00851, MGS, 1 hit
SUPFAMiSSF52335, SSF52335, 1 hit
SSF53927, SSF53927, 1 hit
TIGRFAMsiTIGR00355, purH, 1 hit
PROSITEiView protein in PROSITE
PS51855, MGS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3DKL0_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3DKL0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: April 7, 2021
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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