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Entry version 77 (29 Sep 2021)
Sequence version 1 (22 Jul 2008)
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Protein

Squamous cell carcinoma antigen recognized by T-cells 3

Gene

sart3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation (PubMed:17416673).

May also function as a substrate targeting factor for deubiquitinases and mediate the deubiquitination of components of the spliceosome and histones (By similarity).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Squamous cell carcinoma antigen recognized by T-cells 3Curated
Short name:
SART-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sart3Imported
Synonyms:egy
ORF Names:si:ch211-191d15.4, wu:fc51h03
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040724-10, sart3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

The egy mutant embryos that lack detectable sart3 expression display microcephaly, microphthalmia and die by 7 to 8 dpf. Pharyngeal arch formation is defective resulting in a thymus devoid of lymphocytes and exocrine pancreas development is also impaired.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004315791 – 951Squamous cell carcinoma antigen recognized by T-cells 3Add BLAST951

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B3DJT0

PeptideAtlas

More...
PeptideAtlasi
B3DJT0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000008032, Expressed in blastula and 34 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B3DJT0, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000004923

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B3DJT0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati88 – 120HAT 1Sequence analysisAdd BLAST33
Repeati126 – 157HAT 2Sequence analysisAdd BLAST32
Repeati163 – 199HAT 3Sequence analysisAdd BLAST37
Repeati222 – 255HAT 4Sequence analysisAdd BLAST34
Repeati304 – 336HAT 5Sequence analysisAdd BLAST33
Repeati339 – 371HAT 6Sequence analysisAdd BLAST33
Repeati374 – 410HAT 7Sequence analysisAdd BLAST37
Repeati467 – 500HAT 8Sequence analysisAdd BLAST34
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini688 – 766RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini785 – 862RRM 2PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 58DisorderedSequence analysisAdd BLAST58
Regioni517 – 941Necessary and sufficient for U6 snRNA bindingBy similarityAdd BLAST425
Regioni567 – 686DisorderedSequence analysisAdd BLAST120
Regioni905 – 938DisorderedSequence analysisAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili533 – 593Sequence analysisAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 54Acidic residuesSequence analysisAdd BLAST44
Compositional biasi567 – 608Basic and acidic residuesSequence analysisAdd BLAST42
Compositional biasi617 – 633Basic and acidic residuesSequence analysisAdd BLAST17

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0128, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141107

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007172_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B3DJT0

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B3DJT0

TreeFam database of animal gene trees

More...
TreeFami
TF317554

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12391, RRM1_SART3, 1 hit
cd12392, RRM2_SART3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003107, HAT
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034217, SART3_RRM1
IPR034218, SART3_RRM2
IPR011990, TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076, RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00386, HAT, 7 hits
SM00360, RRM, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit
SSF54928, SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B3DJT0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATGNEEQT LLPDIEEEAE GMEREMESED DEEEGMGVEH SEEEDEEDTS
60 70 80 90 100
EDERENEAEI QRLEEQLSIN AFDYNCHVDL IKLLRQEGKL HRLRKARQKM
110 120 130 140 150
SELFPLTEEI WLDWLKDEIR ITEDESDREK VYELFERAIK DYVCPEIWLE
160 170 180 190 200
YVQYSIGGMG AQGGIERVRS IFERALTAVG LHMTKGASIW EAYREFEIVI
210 220 230 240 250
LSTVQPPPGT VPSQEQQELL SAQLERIHTL FRRQLAVPLM DMEGTYAEYS
260 270 280 290 300
DWADDGVPET VTHQYRRALQ QMEKGKPYEE ALLVSEPPKL AEYQSYIDFE
310 320 330 340 350
IKEGDPARVQ IIFERALAEN CLVPDLWIKY TTYLDRQLKI KDLVLSAHER
360 370 380 390 400
AVRNCPWTMG LWKSYLLALE RHGADHQTVK DVFEKALNAG FIQATDYVEI
410 420 430 440 450
WQSYLDYLRR RVDFSKEWSR ELDELRAAFS RSLEYLKQDV EERFSESGDL
460 470 480 490 500
SCTLMQIWAR IEALHCKNMQ KARELWDSIM TKGNAKYANM WLEYYNLERS
510 520 530 540 550
YGDAAHCRKA LHRAVQCTSD YPEHVCDVLL NFERVEGSLE DWDAAVQKTE
560 570 580 590 600
TKLNRVCEQR ARVAEKEALH ARQEEEKAEQ RRKVKADKKA QKKGQKANRT
610 620 630 640 650
GDKRKAEDDD EEEWGEEAEL PSKRLRGEDD FDSTVTEELM ETESGLFGRR
660 670 680 690 700
APPARKTEPP GFRKNQQGAP EPQRQPHDMP KEQRKDENCV FVSNLTFNME
710 720 730 740 750
DPEGKLRTLF QGCGTIQQVR PVFTAKGTFR GYCYVQFEDR LAVPEALKMD
760 770 780 790 800
RQEVDGRPMY VSPCVDKNKN PDFKVFKYKT SMEKHKIFIS GLPYSATKET
810 820 830 840 850
LEDLCKEHGT IRAIRIVTNR SGKSKGLAYV EFEDEAQASQ AVLKMDGTML
860 870 880 890 900
ENFTLSVAIS NPPGRRMKDE AAPSRFLGAA MPRQLQGARG KGRTQISLLP
910 920 930 940 950
RSLYRQSTPD AKAENGTISA PHATVTDGET SLDTQTKSLS NEDFARMLLK

K
Length:951
Mass (Da):109,735
Last modified:July 22, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFBD6B293A95B156
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6ZM52Q6ZM52_DANRE
Squamous cell carcinoma antigen rec...
sart3
951Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL845326 Genomic DNA No translation available.
BC163594 mRNA Translation: AAI63594.1

NCBI Reference Sequences

More...
RefSeqi
XP_005165211.1, XM_005165154.3
XP_017211593.1, XM_017356104.1
XP_017211594.1, XM_017356105.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000124545; ENSDARP00000106223; ENSDARG00000008032

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
558581

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL845326 Genomic DNA No translation available.
BC163594 mRNA Translation: AAI63594.1
RefSeqiXP_005165211.1, XM_005165154.3
XP_017211593.1, XM_017356104.1
XP_017211594.1, XM_017356105.1

3D structure databases

SMRiB3DJT0
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004923

Proteomic databases

PaxDbiB3DJT0
PeptideAtlasiB3DJT0

Genome annotation databases

EnsembliENSDART00000124545; ENSDARP00000106223; ENSDARG00000008032
GeneIDi558581

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9733
ZFINiZDB-GENE-040724-10, sart3

Phylogenomic databases

eggNOGiKOG0128, Eukaryota
GeneTreeiENSGT00900000141107
HOGENOMiCLU_007172_0_0_1
InParanoidiB3DJT0
PhylomeDBiB3DJT0
TreeFamiTF317554

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
sart3, zebrafish

Protein Ontology

More...
PROi
PR:B3DJT0

Gene expression databases

BgeeiENSDARG00000008032, Expressed in blastula and 34 other tissues
ExpressionAtlasiB3DJT0, baseline and differential

Family and domain databases

CDDicd12391, RRM1_SART3, 1 hit
cd12392, RRM2_SART3, 1 hit
Gene3Di1.25.40.10, 2 hits
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR003107, HAT
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR034217, SART3_RRM1
IPR034218, SART3_RRM2
IPR011990, TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00076, RRM_1, 2 hits
SMARTiView protein in SMART
SM00386, HAT, 7 hits
SM00360, RRM, 2 hits
SUPFAMiSSF48452, SSF48452, 1 hit
SSF54928, SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102, RRM, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSART3_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3DJT0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 7, 2015
Last sequence update: July 22, 2008
Last modified: September 29, 2021
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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