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Entry version 79 (29 Sep 2021)
Sequence version 1 (22 Jul 2008)
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Protein
Submitted name:

Myosin VIIa

Gene

myo7aa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi158 – 165ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotationARBA annotation, Motor protein, MyosinPROSITE-ProRule annotationARBA annotation
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Myosin VIIaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:myo7aaImported
Synonyms:myo7aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-020709-1, myo7aa

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

CytoplasmARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
B3DJQ7, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 741Myosin motorInterPro annotationAdd BLAST677
Domaini1017 – 1253MyTH4InterPro annotationAdd BLAST237
Domaini1258 – 1566FERMInterPro annotationAdd BLAST309
Domaini1564 – 1633SH3InterPro annotationAdd BLAST70
Domaini1709 – 1858MyTH4InterPro annotationAdd BLAST150
Domaini1864 – 2167FERMInterPro annotationAdd BLAST304

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni618 – 640Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili860 – 935Sequence analysisAdd BLAST76

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
LHRGNKH

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473, FERM_B-lobe, 2 hits
cd13198, FERM_C1_MyoVII, 1 hit
cd13199, FERM_C2_MyoVII, 1 hit
cd01381, MYSc_Myo7, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 2 hits
1.25.40.530, 1 hit
2.30.29.30, 2 hits
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR041793, MyoVII_FERM_C1
IPR041794, MyoVII_FERM_C2
IPR036106, MYSc_Myo7
IPR000857, MyTH4_dom
IPR038185, MyTH4_dom_sf
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00373, FERM_M, 2 hits
PF00612, IQ, 3 hits
PF00063, Myosin_head, 1 hit
PF00784, MyTH4, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295, B41, 2 hits
SM00015, IQ, 4 hits
SM00242, MYSc, 1 hit
SM00139, MyTH4, 2 hits
SM00326, SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031, SSF47031, 2 hits
SSF50044, SSF50044, 1 hit
SSF52540, SSF52540, 2 hits
SSF54236, SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50057, FERM_3, 2 hits
PS50096, IQ, 3 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS51016, MYTH4, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3DJQ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVILQQGDYV WLDLKTGHEF EVPIGAVVKL CDSGQIQVLD DEGNEHWISP
60 70 80 90 100
QNATNIKPMH PTSIHGVEDM IRLGDLNEAG ILRNLLIRYR EHLIYTYTGS
110 120 130 140 150
ILVAVNPYQL LPIYTADQIR LYTNKKIGEM PPHIFAIADN CYFNMQRNNK
160 170 180 190 200
DQCCIISGES GAGKTESTKL ILQFLAAISG QHSWIEQQVL EANPILEAFG
210 220 230 240 250
NAKTIRNDNS SRFGKYIDIH FNKRGAIEGA KIEQYLLEKS RVCRQARDER
260 270 280 290 300
NYHIFYCMLK GMTPDQKKQL GLSKATDYTY LTIGNCTVCD GRDDQKEYSN
310 320 330 340 350
IRSAMKVLMF TDKENWEISK LLAAILHMGN LRYEARIYDN LDACEVVRCS
360 370 380 390 400
ALTTAAVLLE VDLKDLMNCL TSRTIITRGE TVSTPLSIEQ ALDVRDAFVK
410 420 430 440 450
GIYGRLFVWI VEKINAAIYK PPSLELKAVR RSIGLLDIFG FENFMVNSFE
460 470 480 490 500
QLCINFANEN LQQFFVRHVF KLEQEEYNLE NINWQHIEFT DNQDALDMIA
510 520 530 540 550
IKPMNIISLI DEESKFPKGT DTTMLNKLNS QHKLNTNYIP PKNTYETQFG
560 570 580 590 600
IQHFAGVVYY ETRGFLEKNR DTLHGDIIQL VHSSKNKFIK QIFQADVAMG
610 620 630 640 650
AETRKRSPTL SSQFKRSLEL LMRTLSVCQP FFVRCIKPNE YKKPMLFDRE
660 670 680 690 700
LCVRQLRYSG MMETIRIRRA GYPIRYTFVE FVDRYRVLMP GVKPAYKQED
710 720 730 740 750
LRGTCQRIAE AVLGRDDDWQ MGKTKIFLKD HHDMLLEIER DKAITDKVIL
760 770 780 790 800
IQKVVRGFKD RSNFLKMKKS AMLIQKTWRG YYCRKNYGAM RGGFSRLQAL
810 820 830 840 850
YRSRKLYQTY HVARQRIMLF QGRCRGFLVR RAFRHRLWAV ITIQAYTRGM
860 870 880 890 900
IARRLYKRLK GEYRRRLEAE KLRLAEEQKL RNQMSARKAK EEAEKMHQER
910 920 930 940 950
LAQLAREDAE REKKERQEAR RKMEMLDQME KARQEPVNDS DMVDKMFGFL
960 970 980 990 1000
GTTNSFPGQE GQAPAGFEDL ERTHRELEVE DLDESLPLPE DDLEDLSEYK
1010 1020 1030 1040 1050
FAKFSATYFQ GTSTHTYMRR PLKQPLLFHE DEGDQLAALA VWITVLRFMG
1060 1070 1080 1090 1100
DLPEPKYHTA ISDGSEKIPV MTKIYETLGK KTYKRELQAL QGEGENTHIE
1110 1120 1130 1140 1150
SHKKSSVRHK LVSLTLKKKS KITEEVTKRL NDGEYTVHGN SMLEDRPTSN
1160 1170 1180 1190 1200
LEKLHFIIGN GILRPGLRDE IYCQICKQLN QNPSKSSHAR GWILMSLCVG
1210 1220 1230 1240 1250
CFAPSEKFVK YLRNFISEGP PGYAPYCEER LRRTFVNGTR TQPPSWLELQ
1260 1270 1280 1290 1300
ATKSKKPIML PVTFMDGTTK TLLTDSATTA KELCNALSDK ISLQDRFGFS
1310 1320 1330 1340 1350
LYIALFDKVS SLGSGNDHVM DAVSQCEQYA KEQGAQERNA PWRLFFRKEI
1360 1370 1380 1390 1400
FTPWHDPAED AVATNLIYQQ IVRGVKFGEY RCDREDLAEL ASQQYYVDYG
1410 1420 1430 1440 1450
SEILVERLLS LIPSYIPDRE ISSAKTVERW AQFIMAAHKK GVYTQKRVDP
1460 1470 1480 1490 1500
QKVKEEVVDF ARYKWPLLFS RFYEAFKFSG PSLPKNDVIV AVNWTGVYFV
1510 1520 1530 1540 1550
DEQEQVLLEL SFPEITAVSS SKGGKLQAQS FTLATIKADE FTFTSNNAED
1560 1570 1580 1590 1600
IRDLVVTFLE GLRKRSKFVV ALQDNPSPAA DDSTFLSFLK GDLIVLDQDT
1610 1620 1630 1640 1650
GEQVMTSGWA HGTNDRTKQR GDFPADCVYV LPTVVRPPHD VVAFVTMTPD
1660 1670 1680 1690 1700
QRQESLRISH VPALTETEER VKPYTLEEFS YDYFRPPPKH TLSRVMITKN
1710 1720 1730 1740 1750
RGKDKLWCCT REPIKQALLK KCGGHEELSQ EACMAFIAVM KYMGDYPSKR
1760 1770 1780 1790 1800
TRSVNELTDQ IFEGALKAEP LKDEIYCQIL KQLTENHIKY SEEKGWELLW
1810 1820 1830 1840 1850
LCVGLFPPSN VLLPHVQRFL QSKKHHPLAL DCMQRLQKAL RNGSRKYPPH
1860 1870 1880 1890 1900
LVEVEAIQHK TTQIFHKVYF PDDTDEAFEV ESSTKAKDFC LNISSRLLLK
1910 1920 1930 1940 1950
TPEGFSLFVK ISDKVISVPE GDFFFDFVRH LTDWIKKARP AKDGIVPSLT
1960 1970 1980 1990 2000
YQVFFMKKLW TTTVPGKDSF ADSIFHYYQE LPKYLRGYHK CSREEVFQLG
2010 2020 2030 2040 2050
ALIYRVKFED DKSHFPSIPK MLKEMIPQDL IRQLSPDDWK RSIVAYFNRH
2060 2070 2080 2090 2100
AGKSREEAKL MFLKIIFKWP TFGSAFFEVK QTTEPHFPEI LLIAINKYGV
2110 2120 2130 2140 2150
SLIDPKNKDI LTTYPFTKIS NWSSGNTYFH ITIGNLVQGS KLLCETSLGY
2160 2170
KMDDLLTSYI SQMLTTMSKQ RNSRGGSSK
Length:2,179
Mass (Da):251,692
Last modified:July 22, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAFCD342E43C6882B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC163570 mRNA Translation: AAI63570.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC163570 mRNA Translation: AAI63570.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiB3DJQ7, 3 interactors

Organism-specific databases

ZFINiZDB-GENE-020709-1, myo7aa

Phylogenomic databases

OMAiLHRGNKH

Family and domain databases

CDDicd14473, FERM_B-lobe, 2 hits
cd13198, FERM_C1_MyoVII, 1 hit
cd13199, FERM_C2_MyoVII, 1 hit
cd01381, MYSc_Myo7, 1 hit
Gene3Di1.20.80.10, 2 hits
1.25.40.530, 1 hit
2.30.29.30, 2 hits
3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR019749, Band_41_domain
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR000299, FERM_domain
IPR000048, IQ_motif_EF-hand-BS
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR041793, MyoVII_FERM_C1
IPR041794, MyoVII_FERM_C2
IPR036106, MYSc_Myo7
IPR000857, MyTH4_dom
IPR038185, MyTH4_dom_sf
IPR027417, P-loop_NTPase
IPR011993, PH-like_dom_sf
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00373, FERM_M, 2 hits
PF00612, IQ, 3 hits
PF00063, Myosin_head, 1 hit
PF00784, MyTH4, 2 hits
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00295, B41, 2 hits
SM00015, IQ, 4 hits
SM00242, MYSc, 1 hit
SM00139, MyTH4, 2 hits
SM00326, SH3, 1 hit
SUPFAMiSSF47031, SSF47031, 2 hits
SSF50044, SSF50044, 1 hit
SSF52540, SSF52540, 2 hits
SSF54236, SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS50057, FERM_3, 2 hits
PS50096, IQ, 3 hits
PS51456, MYOSIN_MOTOR, 1 hit
PS51016, MYTH4, 2 hits
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3DJQ7_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3DJQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 29, 2021
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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