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Entry version 111 (02 Jun 2021)
Sequence version 1 (22 Jul 2008)
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Protein

Metalloendopeptidase

Gene

tll1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi249Zinc; catalyticUniRule annotation1
Metal bindingi249Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei250UniRule annotation1
Metal bindingi253Zinc; catalyticUniRule annotation1
Metal bindingi253Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1
Metal bindingi259Zinc; catalyticUniRule annotation1
Metal bindingi259Zinc; via tele nitrogen; catalyticPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, MetalloproteasePROSITE-ProRule annotationARBA annotation, Protease
LigandMetal-bindingUniRule annotation, ZincUniRule annotationARBA annotation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M12.016

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MetalloendopeptidaseUniRule annotation (EC:3.4.24.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tll1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-041020-1, tll1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 32UniRule annotationAdd BLAST32
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500999613833 – 1022MetalloendopeptidaseUniRule annotationAdd BLAST990

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi219 ↔ 241PROSITE-ProRule annotation
Disulfide bondi221 ↔ 222PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000037429, Expressed in retina and 25 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B3DJN6, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B3DJN6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini157 – 356Peptidase M12AInterPro annotationAdd BLAST200
Domaini358 – 470CUBInterPro annotationAdd BLAST113
Domaini471 – 583CUBInterPro annotationAdd BLAST113
Domaini583 – 624EGF-likeInterPro annotationAdd BLAST42
Domaini627 – 739CUBInterPro annotationAdd BLAST113
Domaini739 – 779EGF-likeInterPro annotationAdd BLAST41
Domaini783 – 895CUBInterPro annotationAdd BLAST113
Domaini896 – 1012CUBInterPro annotationAdd BLAST117

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatARBA annotation, SignalUniRule annotationARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005140_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QADCEWL

Database of Orthologous Groups

More...
OrthoDBi
170905at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041, CUB, 5 hits
cd04281, ZnMc_BMP1_TLD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 5 hits
3.40.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015446, BMP_1/tolloid-like
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024079, MetalloPept_cat_dom_sf
IPR001506, Peptidase_M12A
IPR006026, Peptidase_Metallo
IPR035914, Sperma_CUB_dom_sf
IPR034036, ZnMP_TLD/BMP1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01400, Astacin, 1 hit
PF00431, CUB, 5 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001199, BMP_1/tolloid-like, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00480, ASTACIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042, CUB, 5 hits
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits
SM00235, ZnMc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51864, ASTACIN, 1 hit
PS00010, ASX_HYDROXYL, 2 hits
PS01180, CUB, 5 hits
PS01186, EGF_2, 2 hits
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3DJN6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYLYSALTS KMNWIALLLA GLTFCCKVSV HSCLDYDDSY DYYEEEKTET
60 70 80 90 100
IDYKDPCKAA VFWGDIALDD EDLKMFHIDG TIDLKQQTHG RQGHTSGGLG
110 120 130 140 150
EHVPTKKRGS LYLLLDRIRR LGFESWPVNS SKDVSSIKTG IRRVNSARNV
160 170 180 190 200
KSRVPRAATS RAEKIWPGGV IPYVIGGNFT GSQRAMLKQA MRHWEKQTCV
210 220 230 240 250
TFIEKTDEES YIVFTYRPCG CCSYVGRRGN GPQAISIGKN CDKFGIVVHE
260 270 280 290 300
LGHVIGFWHE HTRPDRDDHV TIIRDNIQPG QEYNFIKMEP GDVNSLGEPY
310 320 330 340 350
DFDSIMHYAR NTFSRGMFLD TILPSRDENG VRPAIGQRTR LSKGDISQAK
360 370 380 390 400
KLYRCPACGE TLQDSVGNFS SPGYPNGYPS YTHCVWRISV TPGEKIVLNF
410 420 430 440 450
TTMDLYKSSL CWYDYIEVRD GYWRKAPLLG RFCGDKIPEV LVSTDSRMWI
460 470 480 490 500
EFRSSSNWVG KGFAAVYEAI CGGEISKDSG QIQSPNYPDD YRPSKECVWR
510 520 530 540 550
ITVSEGYSVG LSFQVFEIER HDSCAYDYLE VRDGLSENSP LIGRFCGYDK
560 570 580 590 600
PEDIRSTSNN LWMKFVSDGT VNKAGFAANF FKEEDECLKP DNGGCEQRCV
610 620 630 640 650
NTLGSFKCAC DPGYELAPDK KSCEAACGGL LTKLNGTITT PGWPKEYPPN
660 670 680 690 700
KNCVWQVVAP TQYRISMQFE AFELEGNEVC KYDYVEVRSG LSSDSKLHGK
710 720 730 740 750
YCGTEVPEVI TSQYNNMRIE FKSDNTVSKK GFKAHFFSDK DECSKDNGGC
760 770 780 790 800
QHECINTIGS YVCQCRNGFI LHENKHDCKE AECEHKIHST TGTISSPNWP
810 820 830 840 850
DKYPSRKECT WDITATPGHR VKISFNEFEI EQHQECAYDH LEAFDGDSDK
860 870 880 890 900
TPILSRLCGN KIPEPLISTG NKMYLRFISD ASVQRKGFQA THSTECGGRL
910 920 930 940 950
KAEARQKNLY SHAQFGDNNY PGHTDCEWLI VAESGYGIEL TFTTFEVEEE
960 970 980 990 1000
ADCGYDYIEL YDGYDTGAHK IGRFCGSGPR EELYSAGDAV LIHFHSDDTI
1010 1020
SKKGFHIRYT STKFQEALHT RK
Length:1,022
Mass (Da):115,536
Last modified:July 22, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA68CA1D0E41793F9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC163547 mRNA Translation: AAI63547.1
BC163569 mRNA Translation: AAI63569.1

NCBI Reference Sequences

More...
RefSeqi
NP_571085.1, NM_131010.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
474335

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:474335

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC163547 mRNA Translation: AAI63547.1
BC163569 mRNA Translation: AAI63569.1
RefSeqiNP_571085.1, NM_131010.1

3D structure databases

SMRiB3DJN6
ModBaseiSearch...

Protein family/group databases

MEROPSiM12.016

Genome annotation databases

GeneIDi474335
KEGGidre:474335

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7092
ZFINiZDB-GENE-041020-1, tll1

Phylogenomic databases

HOGENOMiCLU_005140_0_0_1
OMAiQADCEWL
OrthoDBi170905at2759

Gene expression databases

BgeeiENSDARG00000037429, Expressed in retina and 25 other tissues
ExpressionAtlasiB3DJN6, baseline and differential

Family and domain databases

CDDicd00041, CUB, 5 hits
cd04281, ZnMc_BMP1_TLD, 1 hit
Gene3Di2.60.120.290, 5 hits
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR015446, BMP_1/tolloid-like
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR024079, MetalloPept_cat_dom_sf
IPR001506, Peptidase_M12A
IPR006026, Peptidase_Metallo
IPR035914, Sperma_CUB_dom_sf
IPR034036, ZnMP_TLD/BMP1
PfamiView protein in Pfam
PF01400, Astacin, 1 hit
PF00431, CUB, 5 hits
PIRSFiPIRSF001199, BMP_1/tolloid-like, 1 hit
PRINTSiPR00480, ASTACIN
SMARTiView protein in SMART
SM00042, CUB, 5 hits
SM00181, EGF, 2 hits
SM00179, EGF_CA, 2 hits
SM00235, ZnMc, 1 hit
SUPFAMiSSF49854, SSF49854, 5 hits
PROSITEiView protein in PROSITE
PS51864, ASTACIN, 1 hit
PS00010, ASX_HYDROXYL, 2 hits
PS01180, CUB, 5 hits
PS01186, EGF_2, 2 hits
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3DJN6_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3DJN6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: June 2, 2021
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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