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Protein

Receptor protein serine/threonine kinase

Gene

bmpr1aa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • BMP signaling pathway Source: ZFIN
  • cardiac cell fate specification Source: ZFIN
  • determination of heart left/right asymmetry Source: ZFIN
  • dorsal/ventral pattern formation Source: ZFIN
  • left/right pattern formation Source: ZFIN
  • lymph vessel development Source: ZFIN
  • pattern specification process Source: GO_Central
  • protein homooligomerization Source: ZFIN
  • transforming growth factor beta receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionKinase, ReceptorSAAS annotation, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-201451 Signaling by BMP

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor protein serine/threonine kinaseSAAS annotation (EC:2.7.11.30SAAS annotation)
Gene namesi
Name:bmpr1aaImported
Synonyms:bmpr1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-000502-1 bmpr1aa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei149 – 172HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500278724724 – 526Receptor protein serine/threonine kinaseSequence analysisAdd BLAST503

Interactioni

GO - Molecular functioni

Chemistry databases

BindingDBiB3DJG0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini198 – 227GSInterPro annotationAdd BLAST30
Domaini228 – 519Protein kinaseInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2052 Eukaryota
ENOG410XQT0 LUCA
GeneTreeiENSGT00760000118876
HOGENOMiHOG000230587
HOVERGENiHBG054502

Family and domain databases

InterProiView protein in InterPro
IPR000472 Activin_recp
IPR003605 GS_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF01064 Activin_recp, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF08515 TGF_beta_GS, 1 hit
SMARTiView protein in SMART
SM00467 GS, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51256 GS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

B3DJG0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRQLLFITVV LTGVCLLLTL CSGGQNPDHV LQGTGVKLDS RRPGDDSTIA
60 70 80 90 100
PEDAARFLSC HCSGHCPDDA KNNTCETNGQ CFAIIEEDEN GDVILSSGCM
110 120 130 140 150
KYEGSHFQCK DSQFAQTRRT IECCQFDFCN QDLKPELPPR DSEPPDPHWL
160 170 180 190 200
AFLISVTVCF CALICVTVIC YYRYKWQTER QRYHRDLEQD EAFIPAGESL
210 220 230 240 250
KDLINQSQTS GSGSGLPLLV QRTIAKQIQT VRMIGKGRYG EVWLGRWRGE
260 270 280 290 300
KVAVKVFFTR EEASWFRETE IYQTVLMRHE NILGFIAADI NGTGASTQLY
310 320 330 340 350
LITDYHENGS LYDYLKFTTL DTQALLRLAF SAACGLCHLH TEIYGTQGKP
360 370 380 390 400
AIAHRDLKSK NILIKKNGTC CIADLGLAVK FNSDTNEVDL PLSTRMGTRR
410 420 430 440 450
YMAPEVLDET LNKNHFQAYI MADIYSYGLV IWEMARRCVT GGIVEEYQLP
460 470 480 490 500
YYEMVPSDPS YEDMLEVVCV KGLRPTVSNR WNSDECLRAM LKLMSECWAH
510 520
NPASRLTILR VKKTLAKMVE SQDIKI
Length:526
Mass (Da):59,505
Last modified:July 22, 2008 - v1
Checksum:i749F47873B32EA3D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q1RLX1Q1RLX1_DANRE
Receptor protein serine/threonine k...
bmpr1ba bmpr1aa, zgc:136731
527Annotation score:
Q9W629Q9W629_DANRE
Serine/threonine-protein kinase rec...
bmpr1ba bmpr-IB, bmpr1b
530Annotation score:
F1RC58F1RC58_DANRE
Serine/threonine-protein kinase rec...
bmpr1ba
504Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005174 Genomic DNA No translation available.
CT573135 Genomic DNA No translation available.
BC163471 mRNA Translation: AAI63471.1
RefSeqiXP_005156936.1, XM_005156879.3
UniGeneiDr.78292

Genome annotation databases

EnsembliENSDART00000183723; ENSDARP00000152766; ENSDARG00000019728
GeneIDi58145

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005174 Genomic DNA No translation available.
CT573135 Genomic DNA No translation available.
BC163471 mRNA Translation: AAI63471.1
RefSeqiXP_005156936.1, XM_005156879.3
UniGeneiDr.78292

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiB3DJG0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000183723; ENSDARP00000152766; ENSDARG00000019728
GeneIDi58145

Organism-specific databases

CTDi58145
ZFINiZDB-GENE-000502-1 bmpr1aa

Phylogenomic databases

eggNOGiKOG2052 Eukaryota
ENOG410XQT0 LUCA
GeneTreeiENSGT00760000118876
HOGENOMiHOG000230587
HOVERGENiHBG054502

Enzyme and pathway databases

ReactomeiR-DRE-201451 Signaling by BMP

Family and domain databases

InterProiView protein in InterPro
IPR000472 Activin_recp
IPR003605 GS_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF01064 Activin_recp, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF08515 TGF_beta_GS, 1 hit
SMARTiView protein in SMART
SM00467 GS, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51256 GS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB3DJG0_DANRE
AccessioniPrimary (citable) accession number: B3DJG0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: November 7, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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