Frizzled class receptor 5

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• Wnt-activated receptor activity Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8."
    Momoi A., Yoda H., Steinbeisser H., Fagotto F., Kondoh H., Kudo A., Driever W., Furutani-Seiki M.
    Mech Dev 120:477-489(2003) [PubMed] [Europe PMC] [Abstract]
• Wnt-protein binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• anatomical structure morphogenesis Source: UniProt
• camera-type eye development Source: ZFINInferred from mutant phenotypeⁱ
  • "A secreted WNT-ligand-binding domain of FZD5 generated by a frameshift mutation causes autosomal dominant coloboma."
    UK10K Consortium
    Liu C., Widen S.A., Williamson K.A., Ratnapriya R., Gerth-Kahlert C., Rainger J., Alur R.P., Strachan E., Manjunath S.H., Balakrishnan A., Floyd J.A., Li T., Waskiewicz A., Brooks B.P., Lehmann O.J., FitzPatrick D.R., Swaroop A.
    Hum Mol Genet 25:1382-1391(2016) [PubMed] [Europe PMC] [Abstract]
• canonical Wnt signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• liver development Source: ZFIN <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development."
    Poulain M., Ober E.A.
    Development 138:3557-3568(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of canonical Wnt signaling pathway Source: ZFINInferred from mutant phenotypeⁱ
  • "Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway."
    Cavodeassi F., Carreira-Barbosa F., Young R.M., Concha M.L., Allende M.L., Houart C., Tada M., Wilson S.W.
    Neuron 47:43-56(2005) [PubMed] [Europe PMC] [Abstract]
• non-canonical Wnt signaling pathway Source: ZFINInferred from genetic interactionⁱ
  • "Early stages of zebrafish eye formation require the coordinated activity of Wnt11, Fz5, and the Wnt/beta-catenin pathway."
    Cavodeassi F., Carreira-Barbosa F., Young R.M., Concha M.L., Allende M.L., Houart C., Tada M., Wilson S.W.
    Neuron 47:43-56(2005) [PubMed] [Europe PMC] [Abstract]
• swim bladder development Source: ZFINInferred from mutant phenotypeⁱ
  • "Interplay between Wnt2 and Wnt2bb controls multiple steps of early foregut-derived organ development."
    Poulain M., Ober E.A.
    Development 138:3557-3568(2011) [PubMed] [Europe PMC] [Abstract]
• Wnt signaling pathway Source: ZFINInferred from mutant phenotypeⁱ
  • "Analysis of Wnt8 for neural posteriorizing factor by identifying Frizzled 8c and Frizzled 9 as functional receptors for Wnt8."
    Momoi A., Yoda H., Steinbeisser H., Fagotto F., Kondoh H., Kudo A., Driever W., Furutani-Seiki M.
    Mech Dev 120:477-489(2003) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• Wnt-protein binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MRKPADEHHF TMETSGMHLV GFWLHVLLLF QLSGLGDSAS KDIVCEPITV 
        60         70         80         90        100
PMCKGIGYNH TYMPNQFNHD NQDEVGLEVH QFWPLVRIHC SPDLLFFLCS 
       110        120        130        140        150
MYTPICLQDY KKPLPPCRSV CERAKRGCSP LMIQYGFEWP ERMSCEQLPM 
       160        170        180        190        200
LGDTDRLCMD RNSSETTTLS PPFPKPTPKG TPRHRATAKS APPQKCDREC 
       210        220        230        240        250
HCRGPLVPIK KEAHPLHNRV NTGSLPNCAL PCHQPYFSQD ERTFTTFWIG 
       260        270        280        290        300
LWSVLCFVST FTTVATFLID MERFKYPERP IIFLAACYLF VSLGYIVRLL 
       310        320        330        340        350
AGHERVACEG TGDQQHILYD TTGPALCTLV FLLIYFFGMA SSIWWVVLSF 
       360        370        380        390        400
TWFLAAGMKW GNEAIAGYSQ YFHLAAWLVP SVKSIAVLAL SSVDGDPVAG 
       410        420        430        440        450
ICYVGNQSLE GLRGFVLAPL VVYLFTGSLF LLAGFVSLFR IRSVIKQGGT 
       460        470        480        490        500
KTDKLEKLMI RIGLFTVLYT VPATIVVACL VYEQHYRPSW ERALACSCPS 
       510        520        530        540        550
ERQRLGMGPD YAVFMLKYFM CLVVGITSGV WIWSGKTLES WRRFIARYVP 
       560        570        580        590 
CRTRKPPVSA SSMYSEASTA LTARAGTAPT GTYHKSAPSS HV         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ