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Protein

Tyrosine-protein phosphatase

Gene

ptpn4a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei820SubstrateUniRule annotation1
Active sitei852Phosphocysteine intermediateUniRule annotation1
Binding sitei896SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphataseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:ptpn4aImported
Synonyms:ptpn4Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-030616-449 ptpn4a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonUniRule annotation

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliB3DHD0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 311FERMInterPro annotationAdd BLAST283
Domaini517 – 589PDZInterPro annotationAdd BLAST73
Domaini655 – 911Tyrosine-protein phosphataseInterPro annotationAdd BLAST257
Domaini831 – 902TYR_PHOSPHATASE_2InterPro annotationAdd BLAST72

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni852 – 858Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG410KDUQ Eukaryota
COG5599 LUCA
HOGENOMiHOG000007048
HOVERGENiHBG008322
PhylomeDBiB3DHD0

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014847 FERM-adjacent
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012151 Tyr_Pase_non-rcpt_typ-3/4
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF08736 FA, 1 hit
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00595 PDZ, 1 hit
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000927 Tyr-Ptase_nr3, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01195 FA, 1 hit
SM01196 FERM_C, 1 hit
SM00228 PDZ, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF50156 SSF50156, 1 hit
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS50106 PDZ, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Complete.

B3DHD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTARFRLPAG RSYNVRTTEL ARDRQRTEVV CNILLLDNTV QPFKVNHDQG
60 70 80 90 100
QILLDAVFKH LELTERDYFG LHLADEPSDS PRWLDPNKPI RKQLKRGSPH
110 120 130 140 150
HLNFRVKFFV SDPNKLQEEY TRYQYFLQIK QDILSGRLPC PHNTAALLAS
160 170 180 190 200
YAVQSELGDY SEAENLPGYL SEFFFIPNQP QGFEKDVAKH HQQHNGLNPA
210 220 230 240 250
QSEFNYLNTA RTLDLYGVEL HYARDQSNTE IYVGVLSAGI GIYKNRVRIN
260 270 280 290 300
YFPWLKIVKI SFKCKQFFIQ LRKEAHETRD TLLGFNMVNY RACKNLWKTC
310 320 330 340 350
VEHHTFFRLD RPVPPQKNFF AHYFSLGSRF RYCGRTEAQS VQYGKEKGIK
360 370 380 390 400
DRVFARSPSK PLARKLMGVT DWEAVSRNSL SEERLETRSL PTRSPPGTPN
410 420 430 440 450
HNSLFVQEGP RLRPSSMGHL VDHVIHASPS LPVFSNHKSA SSTQANSISL
460 470 480 490 500
ESTPSPEGVE GPPPALPPKQ SRKNLSQLIL SHSQQDLDNH INEMYDVPTA
510 520 530 540 550
TDKVMPNGVV PHDNLVLIKM KPDENGRFGF NVKGGSDQKM PIIVSRVAPG
560 570 580 590 600
TSADLCVPRL NEGDQVVLIN GREIAEHSHD QVVMFIKASC ESHSGELILL
610 620 630 640 650
VRPNAIYDVV EEKLETEPDF QYIPEKSPTD PSHLDQDAWR DSMLYLKEGL
660 670 680 690 700
NSGTILAQFD QLYRKRPGMT MSCAKLPQNI SKNRYRDISP YDATRVILKG
710 720 730 740 750
TEDYINANYI NMEIPACSLI NRYIACQGPL PNTCSDFWQM TWEQGSSMVV
760 770 780 790 800
MLTTQVERGR VKCHQYWPNP SGSATYGGFQ ISCQTEEGNS AFLVREITLT
810 820 830 840 850
HIESGESREL TQIQYLAWPD HGVPDDSTDF LDFVALVRNK RAGKDEPVVV
860 870 880 890 900
HCSAGIGRTG VLITMETAMC LMECSQPVFP LEIVRTMRDQ RAMMIQTPSQ
910 920
FKFVCEAILK VYEEGLVKPL KSILYESN
Length:928
Mass (Da):105,494
Last modified:July 22, 2008 - v1
Checksum:iD407006D9D489D44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC162720 mRNA Translation: AAI62720.1
UniGeneiDr.96224

Similar proteinsi

Entry informationi

Entry nameiB3DHD0_DANRE
AccessioniPrimary (citable) accession number: B3DHD0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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