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Entry version 117 (29 Sep 2021)
Sequence version 1 (22 Jul 2008)
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Protein
Submitted name:

Neurofibromin 2a (merlin)

Gene

nf2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei293PhosphatidylinositolUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-2029482, Regulation of actin dynamics for phagocytic cup formation
R-DRE-5627123, RHO GTPases activate PAKs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Neurofibromin 2a (merlin)Imported
Submitted name:
Similar to neurofibromin 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nf2aImported
Synonyms:LOC561184Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-080722-7, nf2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membraneARBA annotation, Cytoplasm, CytoskeletonARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B3DGL5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000020204, Expressed in early embryo and 24 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000120670

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B3DGL5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 310FERMInterPro annotationAdd BLAST290

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni75 – 78Phosphatidylinositol bindingUniRule annotation4
Regioni323 – 346DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili440 – 477Sequence analysisAdd BLAST38
Coiled coili517 – 554Sequence analysisAdd BLAST38

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3529, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01020000230354

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003623_6_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
NRITPRP

Database of Orthologous Groups

More...
OrthoDBi
627741at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
B3DGL5

TreeFam database of animal gene trees

More...
TreeFami
TF313935

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14473, FERM_B-lobe, 1 hit
cd13194, FERM_C_ERM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit
2.30.29.30, 1 hit
6.10.360.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019749, Band_41_domain
IPR011174, ERM
IPR011259, ERM_C_dom
IPR041789, ERM_FERM_C
IPR000798, Ez/rad/moesin-like
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR018979, FERM_N
IPR018980, FERM_PH-like_C
IPR008954, Moesin_tail_sf
IPR011993, PH-like_dom_sf
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00769, ERM, 1 hit
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002305, ERM, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00935, BAND41
PR00661, ERMFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00295, B41, 1 hit
SM01196, FERM_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47031, SSF47031, 1 hit
SSF48678, SSF48678, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00660, FERM_1, 1 hit
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B3DGL5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASALASKMG LSLRRKQAKI FNVTVVTMDA DLEFSCELKW RGKDLFELVC
60 70 80 90 100
RTLGLRETWF FGLRYDVKDT VAWLKMDKKV LDHDVPKEEP IVFYFLAKFY
110 120 130 140 150
PENVEEELVQ DITQHLFFLQ VKKSILEEEI YCPPEASVLL ASYAVHAKYG
160 170 180 190 200
DYNPNVHKPG FLSQDELLPK RVINLYQMTA EMWEERITVC YAEHRGRTRD
210 220 230 240 250
EAEMEYLKIA QDLEMYGVNY FSIRNKKGTS LLLGVDALGL HIYDLDNRLT
260 270 280 290 300
PKISFPWNEI RNISYSDKEF AIKPVDKRAD VFKFNSSKLR VNKLILQLCI
310 320 330 340 350
GNHDLFMRRR RVDSLEVQQM KTQAREEKAR KQMERQRLER EKQLREDAER
360 370 380 390 400
ARDELQRRLI QLQDEAHLAN EALLRSEETA DLLAEKAQIA EEEAKLLAQK
410 420 430 440 450
AAEAEQEMQR IKVTAIRSEE EKRLMEQKML EAEMIALKMA EESERRAKEA
460 470 480 490 500
DQLKQDLQEA RESERRAKNK LLEITSKTEY SPVPLSANSL PADGPNFNFS
510 520 530 540 550
MENLSFDFKD TDMKRLSMEI EKEKVEYMEK SKHLQEQLNE LKTEIESLKL
560 570 580 590
KERETPLDIL HNENTEKGTS KQSNFKKLTL QSTKSRVAFF QEL
Length:593
Mass (Da):69,565
Last modified:July 22, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B1B8E4D1C9322F3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL935185 Genomic DNA No translation available.
BC162439 mRNA Translation: AAI62439.1
BC162441 mRNA Translation: AAI62441.1

NCBI Reference Sequences

More...
RefSeqi
NP_001122179.1, NM_001128707.1
XP_005165105.1, XM_005165048.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000132564; ENSDARP00000120670; ENSDARG00000020204
ENSDART00000180681; ENSDARP00000153730; ENSDARG00000020204
ENSDART00000181363; ENSDARP00000153289; ENSDARG00000020204
ENSDART00000186998; ENSDARP00000151081; ENSDARG00000020204

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
561184

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:561184

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL935185 Genomic DNA No translation available.
BC162439 mRNA Translation: AAI62439.1
BC162441 mRNA Translation: AAI62441.1
RefSeqiNP_001122179.1, NM_001128707.1
XP_005165105.1, XM_005165048.3

3D structure databases

SMRiB3DGL5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000120670

Proteomic databases

PeptideAtlasiB3DGL5

Genome annotation databases

EnsembliENSDART00000132564; ENSDARP00000120670; ENSDARG00000020204
ENSDART00000180681; ENSDARP00000153730; ENSDARG00000020204
ENSDART00000181363; ENSDARP00000153289; ENSDARG00000020204
ENSDART00000186998; ENSDARP00000151081; ENSDARG00000020204
GeneIDi561184
KEGGidre:561184

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
561184
ZFINiZDB-GENE-080722-7, nf2a

Phylogenomic databases

eggNOGiKOG3529, Eukaryota
GeneTreeiENSGT01020000230354
HOGENOMiCLU_003623_6_1_1
OMAiNRITPRP
OrthoDBi627741at2759
PhylomeDBiB3DGL5
TreeFamiTF313935

Enzyme and pathway databases

ReactomeiR-DRE-2029482, Regulation of actin dynamics for phagocytic cup formation
R-DRE-5627123, RHO GTPases activate PAKs

Gene expression databases

BgeeiENSDARG00000020204, Expressed in early embryo and 24 other tissues

Family and domain databases

CDDicd14473, FERM_B-lobe, 1 hit
cd13194, FERM_C_ERM, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
6.10.360.10, 1 hit
InterProiView protein in InterPro
IPR019749, Band_41_domain
IPR011174, ERM
IPR011259, ERM_C_dom
IPR041789, ERM_FERM_C
IPR000798, Ez/rad/moesin-like
IPR014352, FERM/acyl-CoA-bd_prot_sf
IPR035963, FERM_2
IPR019748, FERM_central
IPR019747, FERM_CS
IPR000299, FERM_domain
IPR018979, FERM_N
IPR018980, FERM_PH-like_C
IPR008954, Moesin_tail_sf
IPR011993, PH-like_dom_sf
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF00769, ERM, 1 hit
PF09380, FERM_C, 1 hit
PF00373, FERM_M, 1 hit
PF09379, FERM_N, 1 hit
PIRSFiPIRSF002305, ERM, 1 hit
PRINTSiPR00935, BAND41
PR00661, ERMFAMILY
SMARTiView protein in SMART
SM00295, B41, 1 hit
SM01196, FERM_C, 1 hit
SUPFAMiSSF47031, SSF47031, 1 hit
SSF48678, SSF48678, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660, FERM_1, 1 hit
PS00661, FERM_2, 1 hit
PS50057, FERM_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB3DGL5_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B3DGL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 22, 2008
Last sequence update: July 22, 2008
Last modified: September 29, 2021
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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