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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Wolbachia pipientis subsp. Culex pipiens (strain wPip)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi251Magnesium or manganese 1UniRule annotation1
Metal bindingi265Magnesium or manganese 1UniRule annotation1
Metal bindingi265Magnesium or manganese 2UniRule annotation1
Metal bindingi267Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi130 – 183ATPUniRule annotationAdd BLAST54

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:WP0403
OrganismiWolbachia pipientis subsp. Culex pipiens (strain wPip)
Taxonomic identifieri570417 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
Proteomesi
  • UP000008814 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000912151 – 317D-alanine--D-alanine ligaseAdd BLAST317

Interactioni

Protein-protein interaction databases

STRINGi570417.WPa_0403

Structurei

3D structure databases

ProteinModelPortaliB3CPK8
SMRiB3CPK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 299ATP-graspUniRule annotationAdd BLAST197

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
KOiK01921
OMAiYETKYTE
OrthoDBiPOG091H00GT

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

B3CPK8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLMVPNIAIL SGGFSCEREI SLMSGKAVKK ALDSLSYNAI EIDVDSNIAQ
60 70 80 90 100
KLKKTNPALA FIALHGPYGE DGCIQGLLEI LGIKYTHSEV MASAVAMNKV
110 120 130 140 150
MSKHIFHSLN IDTPRGYVIS REDVLKNNIK VDYPYVLKPI NEGSSIGVHM
160 170 180 190 200
IFSHEDYLEL KNNSSTIMEK MIIEEYIPGI ELHTAVLLNE AIGTMEIRPK
210 220 230 240 250
NKFYDYEAKY TDGFAEHIFP AEIPNNIYRI TLEHALKVHQ FLGCKTVSRS
260 270 280 290 300
DFRYNPQNNT LKMLEVNTHP GFTELSLVPE IAKLTRGIDF NELVKIIVED
310
SLHHRNIRDQ ADVEQCY
Length:317
Mass (Da):35,815
Last modified:July 22, 2008 - v1
Checksum:iC60A735F1A8ABDB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM999887 Genomic DNA Translation: CAQ54511.1
RefSeqiWP_012481821.1, NC_010981.1

Genome annotation databases

EnsemblBacteriaiCAQ54511; CAQ54511; WP0403
GeneIDi33019762
KEGGiwpi:WP0403

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM999887 Genomic DNA Translation: CAQ54511.1
RefSeqiWP_012481821.1, NC_010981.1

3D structure databases

ProteinModelPortaliB3CPK8
SMRiB3CPK8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi570417.WPa_0403

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAQ54511; CAQ54511; WP0403
GeneIDi33019762
KEGGiwpi:WP0403

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
KOiK01921
OMAiYETKYTE
OrthoDBiPOG091H00GT

Enzyme and pathway databases

UniPathwayi
UPA00219

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
HAMAPiMF_00047 Dala_Dala_lig, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
PIRSFiPIRSF039102 Ddl/VanB, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDDL_WOLPP
AccessioniPrimary (citable) accession number: B3CPK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 22, 2008
Last modified: October 10, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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