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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Wolbachia pipientis subsp. Culex pipiens (strain wPip)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi482MagnesiumUniRule annotation1
Metal bindingi488MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:WP0831
OrganismiWolbachia pipientis subsp. Culex pipiens (strain wPip)
Taxonomic identifieri570417 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia
Proteomesi
  • UP000008814 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001925051 – 758Polyribonucleotide nucleotidyltransferaseAdd BLAST758

Interactioni

Protein-protein interaction databases

STRINGi570417.WPa_0831

Structurei

3D structure databases

ProteinModelPortaliB3CM21
SMRiB3CM21
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini549 – 608KHUniRule annotationAdd BLAST60
Domaini618 – 686S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR015848 PNPase_PH_RNA-bd_bac/org-type
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF03726 PNPase, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

B3CM21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEIIKKSID WEGRTLSLET GKIARQADGS VVVNYGDTSI LVTVVRKKKE
60 70 80 90 100
ESVDFLPLNV QFIAKSYAMG KIPGGFFKRE GKPSDRETLI SRVIDRSIRP
110 120 130 140 150
LFPEGFHDEI SVVCNLLTYD TVNSPEVPAL IGTVAALAIS GVPFHFTIAG
160 170 180 190 200
VMVGCDENNN YILNPSVQEM KASNLDLFLS GDENSILMVE SEVKELSEEN
210 220 230 240 250
VLNAIKFGHE HLQPVIKLIK EFADTVGNKP ESFAPVDISD ITQELEKYRK
260 270 280 290 300
DFEEAYSKTV KQERVQALEV VRNNILNTLK EAGKDEKLIT YAVKSFERSL
310 320 330 340 350
VREMIRRKSV RIDSRKYDEI RQIEIEADIL PKTHGSALFT RGSTQALVVT
360 370 380 390 400
ALGTTQDEQI VDDIEGDRRE HFMLHYNFPP FAVGEASAIR APGRREIGHG
410 420 430 440 450
KLAWKAIHPV LPDKSEFPYT IRVVSEIMES DGSSSMATVC GTSIALMDTG
460 470 480 490 500
VPIKAPVAGI AMGLIKDKNE HIILSDILGD EDYLGDMDFK VAGTSEGITA
510 520 530 540 550
LQMDMKIPGI SFEIVEKSLE QAKVGRLHIL EKMNAVISEH RKDIKDHVPR
560 570 580 590 600
VLSFYIDKDK ISAAIGTKGK NIRSVCERSN AKIEIGDDGK VSVFAISSTE
610 620 630 640 650
AEAAKNMMID SITELEQGSI IDAKVVKIEK SIVELELLNG RKGKMHISEV
660 670 680 690 700
ANQHVESIED ILKQGDTFKA LIIDFEKGGC PKLSRRRVDQ ETGEFFEGKL
710 720 730 740 750
YNEERRDGLN NRDNYYNNSF NKKPEDNYHS NRPTRPRSGF SNRSRPKFGN

NDSSSGFY
Length:758
Mass (Da):84,663
Last modified:July 22, 2008 - v1
Checksum:i256402174A833358
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM999887 Genomic DNA Translation: CAQ54939.1

Genome annotation databases

EnsemblBacteriaiCAQ54939; CAQ54939; WP0831
KEGGiwpi:WP0831

Entry informationi

Entry nameiPNP_WOLPP
AccessioniPrimary (citable) accession number: B3CM21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 22, 2008
Last modified: February 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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