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Protein

Brevinin-1JDc

Gene
N/A
Organism
Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has antibacterial activity against E.coli ATCC 25992 (MIC=49 µM), E.coli CIB 84492 (MIC=25 µM), S.aureus ATCC 25923 (MIC=6 µM) and S.aureus CIB 85462 (MIC=3 µM).1 Publication

GO - Biological processi

Keywordsi

Molecular functionAmphibian defense peptide, Antibiotic, Antimicrobial, Fungicide

Names & Taxonomyi

Protein namesi
Recommended name:
Brevinin-1JDc1 Publication
OrganismiOdorrana jingdongensis (Jingdong frog) (Rana jingdongensis)
Taxonomic identifieri431936 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaeOdorrana

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00004201391 – 24Brevinin-1JDc1 PublicationAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi18 ↔ 241 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the skin glands.1 Publication

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR012520 Antimicrobial_frog_1
PfamiView protein in Pfam
PF08018 Antimicrobial_1, 1 hit

Sequencei

Sequence statusi: Complete.

B3A0N0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20 
FLPAVLRVAA KVVPTVFCLI SKKC
Length:24
Mass (Da):2,603
Last modified:October 31, 2012 - v1
Checksum:iC2F3F092FBCDBDF4
GO

Mass spectrometryi

Molecular mass is 2600.5215±0.0012 Da from positions 1 - 24. Determined by ESI. 1 Publication

Similar proteinsi

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR012520 Antimicrobial_frog_1
PfamiView protein in Pfam
PF08018 Antimicrobial_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB1JDC_ODOJI
AccessioniPrimary (citable) accession number: B3A0N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: October 31, 2012
Last modified: January 7, 2015
This is version 7 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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