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Entry version 61 (07 Oct 2020)
Sequence version 1 (01 Jul 2008)
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Protein
Submitted name:

ABCB/p-glycoprotein-like protein

Gene
N/A
Organism
Mytilus californianus (California mussel)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi439 – 446ATPPROSITE-ProRule annotation8
Nucleotide bindingi1104 – 1111ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotationARBA annotation, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.201.12, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ABCB/p-glycoprotein-like proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMytilus californianus (California mussel)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6549 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaMolluscaBivalviaPteriomorphiaMytiloidaMytiloideaMytilidaeMytilinaeMytilus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei56 – 75HelicalSequence analysisAdd BLAST20
Transmembranei120 – 144HelicalSequence analysisAdd BLAST25
Transmembranei195 – 214HelicalSequence analysisAdd BLAST20
Transmembranei220 – 237HelicalSequence analysisAdd BLAST18
Transmembranei299 – 321HelicalSequence analysisAdd BLAST23
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Transmembranei748 – 772HelicalSequence analysisAdd BLAST25
Transmembranei792 – 813HelicalSequence analysisAdd BLAST22
Transmembranei867 – 887HelicalSequence analysisAdd BLAST21
Transmembranei971 – 991HelicalSequence analysisAdd BLAST21
Transmembranei1011 – 1029HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
B2WTH9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B2WTH9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini59 – 369ABC transmembrane type-1InterPro annotationAdd BLAST311
Domaini404 – 640ABC transporterInterPro annotationAdd BLAST237
Domaini752 – 1034ABC transmembrane type-1InterPro annotationAdd BLAST283
Domaini1069 – 1306ABC transporterInterPro annotationAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 41DisorderedSequence analysisAdd BLAST41
Regioni661 – 736DisorderedSequence analysisAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 37PolyampholyteSequence analysisAdd BLAST37
Compositional biasi672 – 693PolyampholyteSequence analysisAdd BLAST22
Compositional biasi694 – 712PolarSequence analysisAdd BLAST19

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR030275, MDR3
IPR027417, P-loop_NTPase
IPR039421, Type_I_exporter

The PANTHER Classification System

More...
PANTHERi
PTHR24221, PTHR24221, 1 hit
PTHR24221:SF241, PTHR24221:SF241, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B2WTH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSESEERKPL LADASDEQES YTDDKKTKDE EKKKPEGPPP ATLGQLFRYA
60 70 80 90 100
TSVDTICILF GSLFSLAHGA GWPVLSIVMG QMTDTFVAGP NGSLIPEGPN
110 120 130 140 150
ATFNPNATTE SFEDKMTTYA IYYLIIGGAV LFSGYLQIAC FMTACERQVN
160 170 180 190 200
KIRKHFFRAI LRQEIGWFDK HQSGELTTRL SDDLERVREG IGDKLSLLIQ
210 220 230 240 250
FTAQFFAGFA IGFWKSWKMT LVMMSLTPVL AILAAYFSSL MQNFAKREQA
260 270 280 290 300
LYADAGSVAE EVISCMRTVV SFNGQKQEVK RYGKSLEETK QIGIKKSMVT
310 320 330 340 350
GLLLGSLYLV MFGDYALSFW YGNEQVKEYI TSMGAEGITP GTVLTVFFCV
360 370 380 390 400
MIGSFSIGNA APNIGSFVTA KGAAAVVYEI IDREPKIDAS SEKGQRPLSI
410 420 430 440 450
QGALEFLGVN FTYPTREDVQ VLTNFNLSIK PGQTVALVGS SGCGKSTIVN
460 470 480 490 500
LIQRFYDPDA GQVLLDGNNI KDLNLNWLRQ NIGVVSQEPV LFGCTIAENI
510 520 530 540 550
RLGNPNATIT EIEQAAKQAN AHDFIKSLPQ SYNTLVGERG AQLSGGQKQR
560 570 580 590 600
VAIARALIRD PRILLLDEAT SALDSESENI VQEALEKARQ GRTTLVIAHR
610 620 630 640 650
LSTIQKADII YVVDKGEIIE QGTHGDLMDK QGLYHSLVTA QTLVNEDAGF
660 670 680 690 700
QNQCEDVEFA LEEEEEEEAV DAVPDQTVKR PRSRIKSTSS DDKSPQKLSR
710 720 730 740 750
QMSRQLSRQM SGQPDGKDKA DKEEEPEEQE EYEPPKYFRM IHENQPECGF
760 770 780 790 800
IVLGIMASCV AGCTMPAFAI FFGEMIKVFI ELGNNGLLWS MMFLALGGIN
810 820 830 840 850
FLVYFVQASS FGISGEKLTQ RLRLGTFNAY MRQDIAFFDD KFHSTGALTT
860 870 880 890 900
RLATDASLVK TATGVRIGMV FQSLFGLVAA LVIAFYYGWA LALVVLGIVP
910 920 930 940 950
VIGFASSLQI KVLKGRHEED KGKLEDAGKT AAETIENIRT VQSLTTEKHF
960 970 980 990 1000
YHEYSHALVG PLRSMIKQAH WYGIAFGLGQ GVIFMTYAGA FRFGAWQVEI
1010 1020 1030 1040 1050
GEMTADNVFK VFFAIAFTAM VIGQSSSFLP EYAKAKHAAG LIFKAFDTIP
1060 1070 1080 1090 1100
PIDIYSKRGT YLQKVDGLIQ FKEVNFCYPT RLEVKVLKGV NMKVEPGQTV
1110 1120 1130 1140 1150
ALVGQSGCGK STVISLLQRF YDPESGEIMI DGIDIKDLHL HKMRSFISVV
1160 1170 1180 1190 1200
SQEPILFNCS IRDNIAYGLE ETAGMDDIIT AARDANIHEF ITSQPMGYDT
1210 1220 1230 1240 1250
VVGEKGTQLS GGQKQRVAIA RALIRNPKIL LLDEATSALD SESEKLVQEA
1260 1270 1280 1290 1300
LDKAQEGRTC IVIAHRLSTI QNADVIFVMD NGTIVESGTH QTLLAKKGVY
1310
NSLVSAQQFI K
Length:1,311
Mass (Da):144,505
Last modified:July 1, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i21BD121CF2A46A36
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF521414 mRNA Translation: ABS83556.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF521414 mRNA Translation: ABS83556.1

3D structure databases

SMRiB2WTH9
ModBaseiSearch...

Protein family/group databases

TCDBi3.A.1.201.12, the atp-binding cassette (abc) superfamily

Proteomic databases

PRIDEiB2WTH9

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR030275, MDR3
IPR027417, P-loop_NTPase
IPR039421, Type_I_exporter
PANTHERiPTHR24221, PTHR24221, 1 hit
PTHR24221:SF241, PTHR24221:SF241, 1 hit
PfamiView protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2WTH9_MYTCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2WTH9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: October 7, 2020
This is version 61 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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