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Entry version 85 (02 Jun 2021)
Sequence version 1 (01 Jul 2008)
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Protein

DNA-directed RNA polymerase subunit beta'

Gene

rpoC

Organism
Xanthomonas oryzae pv. oryzae (strain PXO99A)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi70Zinc 1UniRule annotation1
Metal bindingi72Zinc 1UniRule annotation1
Metal bindingi85Zinc 1UniRule annotation1
Metal bindingi88Zinc 1UniRule annotation1
Metal bindingi460MagnesiumUniRule annotation1
Metal bindingi462MagnesiumUniRule annotation1
Metal bindingi464MagnesiumUniRule annotation1
Metal bindingi815Zinc 2UniRule annotation1
Metal bindingi890Zinc 2UniRule annotation1
Metal bindingi897Zinc 2UniRule annotation1
Metal bindingi900Zinc 2UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription
LigandMagnesium, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit beta'UniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit beta'UniRule annotation
Alternative name(s):
RNA polymerase subunit beta'UniRule annotation
Transcriptase subunit beta'UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rpoCUniRule annotation
Ordered Locus Names:PXO_04529
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXanthomonas oryzae pv. oryzae (strain PXO99A)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri360094 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001740 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003534591 – 1405DNA-directed RNA polymerase subunit beta'Add BLAST1405

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
360094.PXO_04529

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11405
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B2SQQ2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1375 – 1405DisorderedSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0086, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000524_3_1_6

Identification of Orthologs from Complete Genome Data

More...
OMAi
YRNIRVE

Database of Orthologous Groups

More...
OrthoDBi
4421at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.132.30, 1 hit
1.10.274.100, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01322, RNApol_bact_RpoC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012754, DNA-dir_RpoC_beta_prime
IPR000722, RNA_pol_asu
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR042102, RNA_pol_Rpb1_3_sf
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR038120, Rpb1_funnel_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 2 hits
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00663, RPOLA_N, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02386, rpoC_TIGR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B2SQQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDLLNLFNQ QRQTLDFDAI KIALASPDLI RSWSYGEVKK PETINYRTFK
60 70 80 90 100
PERDGLFCAA IFGPIKDYEC LCGKYKRMKH RGVVCEKCGT EVTLAKVRRE
110 120 130 140 150
RMGHIDLASP VAHIWFLKSL PSRIGLMLDM TLRDIERVLY FEAYVVTEPG
160 170 180 190 200
LTPLERRQLL TEEQYLTARQ EYNDDFDAAM GAEAVYELLR TIDLQSEMTR
210 220 230 240 250
LREEIASTGS ETKLKRLTKR IKLIEAFLES GNRPEWMVMT VLPVLPPDLR
260 270 280 290 300
PLVPLDGGRF ATSDLNDLYR RVINRNNRLR RLLELNAPDI IVRNEKRMLQ
310 320 330 340 350
ESVDALLDNG RRGRAITGTN KRPLKSLADM IKGKQGRFRQ NLLGKRVDYS
360 370 380 390 400
GRSVITVGPY LKLHQCGLPK KMALELFKPF VFAKLQRRGL ATTIKAAKKL
410 420 430 440 450
VEREEAEVWD ILEEVIREHP VLLNRAPTLH RLGIQAFEPV LIEGKAIQLH
460 470 480 490 500
PLVCTAFNAD FDGDQMAVHV PLSLEAQLEA RALMMSTNNI LSPANGEPII
510 520 530 540 550
VPSQDVVLGL YYMSRALENK KGEGMVFANT SEVKRAYDNR VVELHAKVKV
560 570 580 590 600
RITQVDVDAV DGKRTSGTSI VDTTVGRALL SEILPEGLPF QLANTEMTKK
610 620 630 640 650
NISRLINSSY RLLGLKDTVV FADKLMYTGY AYATRAGVSI GIDDMLIPDE
660 670 680 690 700
KKGILTEAEA EVLEIQEQYQ SGLVTAGERY NKVVDIWSRT SERIAKAMMD
710 720 730 740 750
TIGTEKVENA KGETIDQKSM NSLYIMADSG ARGSQAQIRQ LAGMRGLMAR
760 770 780 790 800
PDGSIIETPI KANFREGLNV QEYFNSTHGA RKGLADTALK TANSGYLTRR
810 820 830 840 850
LVDVAQDVVI TEIDCGTTEG LIMTPIVEGG DVVEPLKERV LGRVVAEDVY
860 870 880 890 900
LPGNDEEPIV TRNTLLDEAW VAKLEDASVQ SVKVRSTISC ESSFGVCARC
910 920 930 940 950
YGRDLARGHQ VNIGEAVGVI AAQSIGEPGT QLTMRTFHIG GAASRAAAVD
960 970 980 990 1000
NITVKTTGSV KFNNLKSVAH ASGSLVAVSR SGELSVLDGH GRERERYKLP
1010 1020 1030 1040 1050
YGATITAKDG DAVKAGQSVA NWDPHNHPIV SEVAGFIRFI DFVDGVTVIE
1060 1070 1080 1090 1100
KTDELTGLAS REITDPKRRG AHAKELRPIV RIVDGKGNDL TIPNTDLPAQ
1110 1120 1130 1140 1150
YLLPPRSIVN LQDGAAVGVG DVVAKIPQEA SKTRDITGGL PRVADLFEAR
1160 1170 1180 1190 1200
KPKDPAILAE RSGIISFGKD TKGKQRLIIK DTDGSEHEEL IPKYRQIIVF
1210 1220 1230 1240 1250
EGEHVTKGET VVDGEPSPQD ILRLLGVEPL AAYLVKEIQD VYRLQGVKIN
1260 1270 1280 1290 1300
DKHIEVITRQ MLRKVEIVDQ GNSKFLNGEQ VERQRVIEEN ARLVKRNELP
1310 1320 1330 1340 1350
AKYDPVLLGI TKASLATESF ISAASFQETT RVLTEAAVRG TRDNLRGLKE
1360 1370 1380 1390 1400
NVIVGRLIPA GTGLAYHAGR RKASGLTDSE METLSGKPAG AEPVAALADA

GADEE
Length:1,405
Mass (Da):155,232
Last modified:July 1, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16AAA34E5554208F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP000967 Genomic DNA Translation: ACD57879.1

NCBI Reference Sequences

More...
RefSeqi
WP_011260033.1, NC_010717.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
ACD57879; ACD57879; PXO_04529

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xop:PXO_04529

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000967 Genomic DNA Translation: ACD57879.1
RefSeqiWP_011260033.1, NC_010717.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6J9Eelectron microscopy3.41D1-1405[»]
6J9Felectron microscopy3.95D1-1405[»]
SMRiB2SQQ2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi360094.PXO_04529

Genome annotation databases

EnsemblBacteriaiACD57879; ACD57879; PXO_04529
KEGGixop:PXO_04529

Phylogenomic databases

eggNOGiCOG0086, Bacteria
HOGENOMiCLU_000524_3_1_6
OMAiYRNIRVE
OrthoDBi4421at2

Family and domain databases

Gene3Di1.10.132.30, 1 hit
1.10.274.100, 1 hit
HAMAPiMF_01322, RNApol_bact_RpoC, 1 hit
InterProiView protein in InterPro
IPR012754, DNA-dir_RpoC_beta_prime
IPR000722, RNA_pol_asu
IPR006592, RNA_pol_N
IPR007080, RNA_pol_Rpb1_1
IPR007066, RNA_pol_Rpb1_3
IPR042102, RNA_pol_Rpb1_3_sf
IPR007083, RNA_pol_Rpb1_4
IPR007081, RNA_pol_Rpb1_5
IPR038120, Rpb1_funnel_sf
PfamiView protein in Pfam
PF04997, RNA_pol_Rpb1_1, 1 hit
PF00623, RNA_pol_Rpb1_2, 2 hits
PF04983, RNA_pol_Rpb1_3, 1 hit
PF05000, RNA_pol_Rpb1_4, 1 hit
PF04998, RNA_pol_Rpb1_5, 1 hit
SMARTiView protein in SMART
SM00663, RPOLA_N, 1 hit
TIGRFAMsiTIGR02386, rpoC_TIGR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPOC_XANOP
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2SQQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: July 1, 2008
Last modified: June 2, 2021
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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