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Protein

Phosphoenolpyruvate carboxykinase [GTP]

Gene

pckG

Organism
Treponema pallidum subsp. pallidum (strain SS14)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei71SubstrateUniRule annotation1
Metal bindingi222ManganeseUniRule annotation1
Metal bindingi242Manganese; via tele nitrogenUniRule annotation1
Binding sitei264SubstrateUniRule annotation1
Active sitei266UniRule annotation1
Metal bindingi289ManganeseUniRule annotation1
Binding sitei387GTPUniRule annotation1
Binding sitei418GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi265 – 270GTPUniRule annotation6
Nucleotide bindingi514 – 517GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processGluconeogenesis
LigandGTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation (EC:4.1.1.32UniRule annotation)
Short name:
PEP carboxykinaseUniRule annotation
Short name:
PEPCKUniRule annotation
Gene namesi
Name:pckGUniRule annotation
Ordered Locus Names:TPASS_0122
OrganismiTreponema pallidum subsp. pallidum (strain SS14)
Taxonomic identifieri455434 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000001202 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001250481 – 618Phosphoenolpyruvate carboxykinase [GTP]Add BLAST618

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB2S270
SMRiB2S270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni213 – 215Substrate bindingUniRule annotation3
Regioni385 – 387Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000191700
KOiK01596
OMAiCWLALTD

Family and domain databases

CDDicd00819 PEPCK_GTP, 1 hit
Gene3Di3.40.449.10, 2 hits
3.90.228.20, 2 hits
HAMAPiMF_00452 PEPCK_GTP, 1 hit
InterProiView protein in InterPro
IPR018091 PEP_carboxykin_GTP_CS
IPR013035 PEP_carboxykinase_C
IPR008209 PEP_carboxykinase_GTP
IPR035077 PEP_carboxykinase_GTP_C
IPR035078 PEP_carboxykinase_GTP_N
IPR008210 PEP_carboxykinase_N
PANTHERiPTHR11561 PTHR11561, 1 hit
PfamiView protein in Pfam
PF00821 PEPCK_C, 1 hit
PF17297 PEPCK_N, 1 hit
PIRSFiPIRSF001348 PEP_carboxykinase_GTP, 1 hit
SUPFAMiSSF68923 SSF68923, 1 hit
PROSITEiView protein in PROSITE
PS00505 PEPCK_GTP, 1 hit

Sequencei

Sequence statusi: Complete.

B2S270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELHEIAHAR AKAWIEEMVA LCAPDTVYVC DGSKKEYDTI MQKMVDAGLA
60 70 80 90 100
TPLKKRKNCF LFRSQPSDVA RVEARTFIAS KREDDAGPTN HWTDPAELKK
110 120 130 140 150
TMTGLYSQCM KGRTMYVIPF SMGPVGSPIS KNGIEITDSE YVVCNMHIMT
160 170 180 190 200
RVGTRVLEAL GTDGEFVPCL HSVGKPLGPG VTDAGQWPCA DMERKYISHF
210 220 230 240 250
PEERLVWSFG SGYGGNALLG KKCFALRIAS VLARDEGWLA EHMLILKITN
260 270 280 290 300
PAGKTKYIGA AFPSACGKTN LAMMIPTLPG WKVETVGDDI AWMKFGKDGR
310 320 330 340 350
LYAINPEAGF FGVAPGTSDF SNKNAMDSIK ENAIFTNCGL TEDGDVWWEG
360 370 380 390 400
IGYPAKGTII DWHGVSRPAP TRDKSPKGEE IAHPNARFTA PARQCPAIAS
410 420 430 440 450
NWEDPEGVPI DAFLFGGRRP STVPLVHQAR DWNHGVFLGS IIGSEVTAAV
460 470 480 490 500
ISDQVGQIRR DPFAMLPFCG YHMADYFSHW IKLGSQARAE NLPKIFCVNW
510 520 530 540 550
FRKDAEGNFL WPGYGDNSRV LAWIFDRCDG VDNAVETAIG WMPKEGALNT
560 570 580 590 600
EGLNVSTQAV KELLSVDIAG WKKEIKDIRE NHYPKFGARL PQQLRDALEV
610
LEARINGSEG AACTRDMC
Length:618
Mass (Da):68,125
Last modified:July 1, 2008 - v1
Checksum:i4230B8F77DDD4AA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000805 Genomic DNA Translation: ACD70549.1
RefSeqiWP_010881571.1, NC_021508.1

Genome annotation databases

EnsemblBacteriaiACD70549; ACD70549; TPASS_0122
GeneIDi34332254
KEGGitpp:TPASS_0122
PATRICifig|455434.6.peg.125

Similar proteinsi

Entry informationi

Entry nameiPCKG_TREPS
AccessioniPrimary (citable) accession number: B2S270
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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