UniProtKB - B2RZ72 (B2RZ72_RAT)
Protein
Actin-related protein 2/3 complex subunit 4
Gene
Arpc4
Organism
Rattus norvegicus (Rat)
Status
Functioni
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.UniRule annotation
GO - Molecular functioni
- actin filament binding Source: Ensembl
- enzyme binding Source: RGD
- protein-macromolecule adaptor activity Source: Ensembl
- structural constituent of cytoskeleton Source: RGD
GO - Biological processi
- actin filament polymerization Source: UniProtKB-UniRule
- Arp2/3 complex-mediated actin nucleation Source: RGD
Keywordsi
Molecular function | Actin-bindingUniRule annotation |
Enzyme and pathway databases
Reactomei | R-RNO-2029482, Regulation of actin dynamics for phagocytic cup formation R-RNO-3928662, EPHB-mediated forward signaling R-RNO-8856828, Clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Actin-related protein 2/3 complex subunit 4UniRule annotation |
Gene namesi | ORF Names:rCG_56555Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1310096, Arpc4 |
Subcellular locationi
Cytoskeleton
- cytoskeleton UniRule annotation
Other locations
- Cell projection ARBA annotation
Cytoskeleton
- Arp2/3 protein complex Source: RGD
Other locations
- cell projection Source: UniProtKB-SubCell
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, CytoskeletonUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000008994, Expressed in thymus and 21 other tissues |
Interactioni
GO - Molecular functioni
- actin filament binding Source: Ensembl
- enzyme binding Source: RGD
Protein-protein interaction databases
IntActi | B2RZ72, 1 interactor |
STRINGi | 10116.ENSRNOP00000011937 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1876, Eukaryota |
GeneTreei | ENSGT00390000016233 |
HOGENOMi | CLU_084855_1_0_1 |
OMAi | RFMMQRA |
OrthoDBi | 1351067at2759 |
TreeFami | TF105621 |
Family and domain databases
Gene3Di | 3.30.1460.20, 1 hit |
InterProi | View protein in InterPro IPR034666, ARPC2/4 IPR008384, ARPC4 |
PANTHERi | PTHR22629, PTHR22629, 1 hit |
Pfami | View protein in Pfam PF05856, ARPC4, 1 hit |
PIRSFi | PIRSF039100, ARPC4, 1 hit |
SUPFAMi | SSF69645, SSF69645, 1 hit |
i Sequence
Sequence statusi: Complete.
B2RZ72-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP
60 70 80 90 100
VTISRNEKEK VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN
110 120 130 140 150
FFILRRKPVE GYDISFLITN FHTEQMYKHK LVDFVIHFME EIDKEISEMK
160
LSVNARARIV AEEFLKNF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC183952 Genomic DNA No translation available. BC167049 mRNA Translation: AAI67049.1 CH473957 Genomic DNA Translation: EDL91528.1 |
RefSeqi | NP_001100085.2, NM_001106615.2 |
Genome annotation databases
Ensembli | ENSRNOT00000011937; ENSRNOP00000011937; ENSRNOG00000008994 |
GeneIDi | 297518 |
KEGGi | rno:297518 |
UCSCi | RGD:1310096, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC183952 Genomic DNA No translation available. BC167049 mRNA Translation: AAI67049.1 CH473957 Genomic DNA Translation: EDL91528.1 |
RefSeqi | NP_001100085.2, NM_001106615.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | B2RZ72, 1 interactor |
STRINGi | 10116.ENSRNOP00000011937 |
Genome annotation databases
Ensembli | ENSRNOT00000011937; ENSRNOP00000011937; ENSRNOG00000008994 |
GeneIDi | 297518 |
KEGGi | rno:297518 |
UCSCi | RGD:1310096, rat |
Organism-specific databases
CTDi | 10093 |
RGDi | 1310096, Arpc4 |
Phylogenomic databases
eggNOGi | KOG1876, Eukaryota |
GeneTreei | ENSGT00390000016233 |
HOGENOMi | CLU_084855_1_0_1 |
OMAi | RFMMQRA |
OrthoDBi | 1351067at2759 |
TreeFami | TF105621 |
Enzyme and pathway databases
Reactomei | R-RNO-2029482, Regulation of actin dynamics for phagocytic cup formation R-RNO-3928662, EPHB-mediated forward signaling R-RNO-8856828, Clathrin-mediated endocytosis |
Gene expression databases
Bgeei | ENSRNOG00000008994, Expressed in thymus and 21 other tissues |
Family and domain databases
Gene3Di | 3.30.1460.20, 1 hit |
InterProi | View protein in InterPro IPR034666, ARPC2/4 IPR008384, ARPC4 |
PANTHERi | PTHR22629, PTHR22629, 1 hit |
Pfami | View protein in Pfam PF05856, ARPC4, 1 hit |
PIRSFi | PIRSF039100, ARPC4, 1 hit |
SUPFAMi | SSF69645, SSF69645, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | B2RZ72_RAT | |
Accessioni | B2RZ72Primary (citable) accession number: B2RZ72 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | December 2, 2020 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |