UniProtKB - B2RYJ8 (ESRP2_RAT)
Epithelial splicing regulatory protein 2
Esrp2
Functioni
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity).
By similarityGO - Molecular functioni
- mRNA binding Source: UniProtKB
- RNA binding Source: GO_Central
GO - Biological processi
- alternative mRNA splicing, via spliceosome Source: RGD
- branching involved in salivary gland morphogenesis Source: RGD
- epithelial tube branching involved in lung morphogenesis Source: RGD
- positive regulation of epithelial cell proliferation Source: RGD
- regulation of RNA splicing Source: UniProtKB
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
Reactomei | R-RNO-6803529, FGFR2 alternative splicing |
Names & Taxonomyi
Protein namesi | Recommended name: Epithelial splicing regulatory protein 2Alternative name(s): RNA-binding motif protein 35B RNA-binding protein 35B |
Gene namesi | Name:Esrp2 Synonyms:Rbm35b |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1310855, Esrp2 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: GO_Central
- nucleus Source: UniProtKB
Other locations
- ribonucleoprotein complex Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000370632 | 1 – 716 | Epithelial splicing regulatory protein 2Add BLAST | 716 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 83 | PhosphoserineBy similarity | 1 | |
Modified residuei | 562 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | B2RYJ8 |
PeptideAtlasi | B2RYJ8 |
PRIDEi | B2RYJ8 |
PTM databases
iPTMneti | B2RYJ8 |
PhosphoSitePlusi | B2RYJ8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 246 – 342 | RRM 1Add BLAST | 97 | |
Domaini | 347 – 427 | RRM 2Add BLAST | 81 | |
Domaini | 464 – 544 | RRM 3Add BLAST | 81 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 20 | Pro residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1365, Eukaryota |
InParanoidi | B2RYJ8 |
PhylomeDBi | B2RYJ8 |
Family and domain databases
Gene3Di | 3.30.420.10, 1 hit 3.30.70.330, 3 hits |
InterProi | View protein in InterPro IPR034431, ESRP2 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf IPR000504, RRM_dom |
PANTHERi | PTHR13976:SF30, PTHR13976:SF30, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 3 hits |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF54928, SSF54928, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MTPPPPPPPP PGPDPAVDSS TDPCPEPQSL VVLFGATAGA LGPDLGSDET
60 70 80 90 100
DLILLVWQVV EPRSRQVGTL HKSLVRAEAA ALSPQCREAS GLSADSLARA
110 120 130 140 150
ESLDKVLQQF SQLVSGDVAL LGGGPYVLCT DGQQLLRQVL HPEASRKNLV
160 170 180 190 200
LPDTFFSFYD LRREFHVQHP STCSARDLTV GTMAQDLGLE TDATEDDFGV
210 220 230 240 250
WEVKTMVAVI LHLLEGPNGH LFSKPEVVKQ KYETGPCKAD VVDNETVVRA
260 270 280 290 300
RGLPWQSSDQ DVARFFKGLN IARGGVALCL NAQGRRNGEA LIRFEDSEQR
310 320 330 340 350
DLALQRHKHH MGVRYIEVYK ATGEEFVKIA GGTSLEVARF LSREDQVILR
360 370 380 390 400
LRGLPFSAGP ADVLDFLGPE CPVTGGVDGL LFVRHPDGRP TGDAFALFAC
410 420 430 440 450
EELAQAALRR HKGMLGKRYI ELFRSTAAEV QQVLNRYAAS PLLPTLTAPL
460 470 480 490 500
LPIPFPLAGG TGRDCVRLRG LPYTATIEDI LSFLGEAAAD IRPHGVHMVL
510 520 530 540 550
NQQGRPSGDA FIQMMSVERA LAAAQRCHKK VMKERYVEVV PCSTEEMSRV
560 570 580 590 600
LMGGSLSRSG LSPPPCKLPC LSPPTYATFQ ASPALIPTET TALYPSSALL
610 620 630 640 650
PAARVPAAAT PLAYYPGPAT QLYMNYTAYY PSPPVSPTTV GYLTTPPTAL
660 670 680 690 700
ASTPTSMLSQ PGALVRMQGV PYTAGMKDLL SVFQAYQLAP DDYATLVPVG
710
DPPRTVLQAP KEWVCL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V8M2 | G3V8M2_RAT | Epithelial splicing regulatory prot... | Esrp2 Rbm35b_predicted, rCG_51538 | 717 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC166804 mRNA Translation: AAI66804.1 |
RefSeqi | XP_006255558.1, XM_006255496.3 |
Genome annotation databases
GeneIDi | 307810 |
UCSCi | RGD:1310855, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC166804 mRNA Translation: AAI66804.1 |
RefSeqi | XP_006255558.1, XM_006255496.3 |
3D structure databases
SMRi | B2RYJ8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000026873 |
PTM databases
iPTMneti | B2RYJ8 |
PhosphoSitePlusi | B2RYJ8 |
Proteomic databases
PaxDbi | B2RYJ8 |
PeptideAtlasi | B2RYJ8 |
PRIDEi | B2RYJ8 |
Genome annotation databases
GeneIDi | 307810 |
UCSCi | RGD:1310855, rat |
Organism-specific databases
CTDi | 80004 |
RGDi | 1310855, Esrp2 |
Phylogenomic databases
eggNOGi | KOG1365, Eukaryota |
InParanoidi | B2RYJ8 |
PhylomeDBi | B2RYJ8 |
Enzyme and pathway databases
Reactomei | R-RNO-6803529, FGFR2 alternative splicing |
Miscellaneous databases
PROi | PR:B2RYJ8 |
Family and domain databases
Gene3Di | 3.30.420.10, 1 hit 3.30.70.330, 3 hits |
InterProi | View protein in InterPro IPR034431, ESRP2 IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf IPR000504, RRM_dom |
PANTHERi | PTHR13976:SF30, PTHR13976:SF30, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 3 hits |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF54928, SSF54928, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ESRP2_RAT | |
Accessioni | B2RYJ8Primary (citable) accession number: B2RYJ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | July 1, 2008 | |
Last modified: | June 2, 2021 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families