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Entry version 97 (31 Jul 2019)
Sequence version 1 (01 Jul 2008)
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Protein
Submitted name:

Anapc2 protein

Gene

Anapc2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-RNO-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-RNO-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-RNO-174154 APC/C:Cdc20 mediated degradation of Securin
R-RNO-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-RNO-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-RNO-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-RNO-176408 Regulation of APC/C activators between G1/S and early anaphase
R-RNO-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-RNO-176412 Phosphorylation of the APC/C
R-RNO-179409 APC-Cdc20 mediated degradation of Nek2A
R-RNO-2467813 Separation of Sister Chromatids
R-RNO-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-RNO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Anapc2 proteinImported
Submitted name:
Anaphase-promoting complex subunit 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Anapc2Imported
ORF Names:rCG_45762Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...
RGDi
1305546 Anapc2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000011295 Expressed in 10 organ(s), highest expression level in brain

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000015099

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini516 – 714CULLIN_2InterPro annotationAdd BLAST199

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni477 – 508DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi480 – 497AcidicSequence analysisAdd BLAST18

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cullin family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2165 Eukaryota
ENOG410XRBY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016127

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033936

KEGG Orthology (KO)

More...
KOi
K03349

Identification of Orthologs from Complete Genome Data

More...
OMAi
SMVVDIY

Database of Orthologous Groups

More...
OrthoDBi
570797at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105442

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014786 APC_su2_C
IPR016158 Cullin_homology
IPR036317 Cullin_homology_sf
IPR001373 Cullin_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08672 ANAPC2, 1 hit
PF00888 Cullin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01013 APC2, 1 hit
SM00182 CULLIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit
SSF75632 SSF75632, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50069 CULLIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B2RYJ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAEGVAVSV AAAAAATTTI VATDDCDSRP GQELVVAWNT VSTGLVPPAA
60 70 80 90 100
LGLASSRTSG AVPPKEEELR AAVEVLRAHG LHSVLEEWFV EVLQNDLQGN
110 120 130 140 150
IATEFWNAIS LRENSVDEPQ CLVLLLDAFG LLESRLDPYL HSLELLEKWT
160 170 180 190 200
RLGLLMGAGA QGLREKVHTM LRGVLFFSTP RTFQEMVQRL YGRFLRVYMQ
210 220 230 240 250
SKRKGEGGTD PELEGELDSR YARRRYYRLL QSPLCAGCGS DKQQCWCRQA
260 270 280 290 300
LEQFNQLSQV LHRLSLLERV SAEAVTTTLH QVTRERMEDR CRGEYERSFL
310 320 330 340 350
REFHKWIERV VGWLGKVFLQ DNPSRPTSPE AGNTLRRWRC HVQRFFYRIY
360 370 380 390 400
ASLRIEELFS IIRDFPDSRP AIEDLKYCLE RTDQRQQLLV SLKVALETRL
410 420 430 440 450
LHPGVNTCDI ITLYISAIKA LRVLDPSMVI LEVACEPIRR YLRTREDTVR
460 470 480 490 500
QIVAGLTGDS DGTGDLAVEL SKTDPACLET GQDSEDDSGE PEDWVPDPVD
510 520 530 540 550
ADPAKSSSKR RSSDIISLLV SIYGSKDLFI NEYRSLLADR LLHQFSFSPE
560 570 580 590 600
REIRNVELLK LRFGEAPMHF CEVMLKDMAD SRRINANIRE EDEKRPVEEQ
610 620 630 640 650
PPFGVYAVIL SSEFWPPFKD EKLEVPEDIR AALDVYCKKY EKLKAMRTLS
660 670 680 690 700
WKHTLGLVTM DVELADRTLS VAVTPVQAVV LLYFQDQASW TLEELSKVVK
710 720 730 740 750
MPVALLRRRM SVWLQQGVLR EEPPGTFSVI EEERPQDRDN MVLIDSDDES
760 770 780 790 800
DSGMASQADQ KEEELLLFWT YIQAMLTNLE SLSLERIYSM LRMFVMTGPA
810 820 830
LAEIDLQELQ GYLQKKVRDQ QLIYSAGVYR LPKNCN
Length:836
Mass (Da):95,373
Last modified:July 1, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1951710BE2400FA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07051241 Genomic DNA No translation available.
BC166796 mRNA Translation: AAI66796.1
CH474001 Genomic DNA Translation: EDL93618.1

NCBI Reference Sequences

More...
RefSeqi
NP_001094002.1, NM_001100532.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000015099; ENSRNOP00000015099; ENSRNOG00000011295

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
296558

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:296558

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07051241 Genomic DNA No translation available.
BC166796 mRNA Translation: AAI66796.1
CH474001 Genomic DNA Translation: EDL93618.1
RefSeqiNP_001094002.1, NM_001100532.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015099

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000015099; ENSRNOP00000015099; ENSRNOG00000011295
GeneIDi296558
KEGGirno:296558

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29882
RGDi1305546 Anapc2

Phylogenomic databases

eggNOGiKOG2165 Eukaryota
ENOG410XRBY LUCA
GeneTreeiENSGT00390000016127
HOGENOMiHOG000033936
KOiK03349
OMAiSMVVDIY
OrthoDBi570797at2759
TreeFamiTF105442

Enzyme and pathway databases

ReactomeiR-RNO-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-RNO-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-RNO-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-RNO-174154 APC/C:Cdc20 mediated degradation of Securin
R-RNO-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-RNO-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-RNO-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-RNO-176408 Regulation of APC/C activators between G1/S and early anaphase
R-RNO-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-RNO-176412 Phosphorylation of the APC/C
R-RNO-179409 APC-Cdc20 mediated degradation of Nek2A
R-RNO-2467813 Separation of Sister Chromatids
R-RNO-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-RNO-69017 CDK-mediated phosphorylation and removal of Cdc6
R-RNO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

BgeeiENSRNOG00000011295 Expressed in 10 organ(s), highest expression level in brain

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR014786 APC_su2_C
IPR016158 Cullin_homology
IPR036317 Cullin_homology_sf
IPR001373 Cullin_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF08672 ANAPC2, 1 hit
PF00888 Cullin, 1 hit
SMARTiView protein in SMART
SM01013 APC2, 1 hit
SM00182 CULLIN, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF75632 SSF75632, 1 hit
PROSITEiView protein in PROSITE
PS50069 CULLIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2RYJ1_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2RYJ1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 31, 2019
This is version 97 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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