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Protein
Submitted name:

Interleukin-1 receptor-associated kinase 1

Gene

Irak1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseImported, ReceptorImported, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-1257604 PIP3 activates AKT signaling
R-RNO-168638 NOD1/2 Signaling Pathway
R-RNO-209543 p75NTR recruits signalling complexes
R-RNO-209560 NF-kB is activated and signals survival
R-RNO-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-RNO-450302 activated TAK1 mediates p38 MAPK activation
R-RNO-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-RNO-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-RNO-9020702 Interleukin-1 signaling
R-RNO-937039 IRAK1 recruits IKK complex
R-RNO-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-RNO-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-RNO-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-RNO-975155 MyD88 dependent cascade initiated on endosome

Names & Taxonomyi

Protein namesi
Submitted name:
Interleukin-1 receptor-associated kinase 1Imported
Submitted name:
Interleukin-1 receptor-associated kinase 1 (Predicted)Imported
Submitted name:
Irak1 proteinImported
Gene namesi
Name:Irak1Imported
Synonyms:Irak1_predictedImported
ORF Names:rCG_43846Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1563841 Irak1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000060869

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000061751

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini212 – 521Protein kinaseInterPro annotationAdd BLAST310

Phylogenomic databases

eggNOGiKOG1187 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00530000063073
HOGENOMiHOG000015226
HOVERGENiHBG052144
KOiK04730
OMAiGFYCLVY
OrthoDBiEOG091G0YKT

Family and domain databases

CDDicd08794 Death_IRAK1, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR035533 Death_IRAK1
IPR035536 IRAK1
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24419:SF1 PTHR24419:SF1, 1 hit
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

B2RYH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGPGPGEP VVPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV
60 70 80 90 100
RDQTELRLCE RSEQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT
110 120 130 140 150
AWHPPASVLP PSTGAPRPSS ISAGSETEDW SPRKLQSSAS TFLSPAFPGS
160 170 180 190 200
QTHSESELLQ VPLSDSLGPP LQSSAPSSIK PSPESPVSGL QRARPSPFCW
210 220 230 240 250
PFCEISQGTC NFSEELRIGE GGFGCVYRAV MRNTTYAVKR LKEEADLEWT
260 270 280 290 300
VVKQSFLTEV EQLSRFRHPN IVDFAGYCAE SGFYCLVYGF LPNGSLEDQL
310 320 330 340 350
HLQTQACSPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE
360 370 380 390 400
RLMPKLGDFG LARFSRFAGA NPSQSSTVAR TCTVRGTLAY LPEEYIKTGR
410 420 430 440 450
LAVDTDTFSF GVVILETLAG QRAVRTQGAK TKYLKDLIED EAEEVGVTLK
460 470 480 490 500
STQPTLWMGV ATDAWTAPIA AQIYKKHLDS RPGPCPPQLG LALAQLACCC
510 520 530 540 550
MHRRAKKRPP MTQVYKRLEG LQAVPPWKLE VAGHGSPSPQ ENSYMSTTGS
560 570 580 590 600
AQSGDEPWQP LVVTTRAPAQ AAQQLQRSPN QPVESDESVP GLSATLHSWH
610 620 630 640 650
LTPDSHPSPV SFREASCTQG GTTRESSLRS GPGFQPTTME GSSMGSSSLL
660 670 680 690 700
SSEPPQIIIN PARQKMVQKL ALYEEGVLDS LQLLSSGFFP GLDLEPEKRK
710
RPEESDEFQS
Length:710
Mass (Da):77,859
Last modified:July 1, 2008 - v1
Checksum:iD6B36D1B306998E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC106169 Genomic DNA No translation available.
BC166780 mRNA Translation: AAI66780.1
CH474099 Genomic DNA Translation: EDL84996.1
RefSeqiNP_001121027.1, NM_001127555.1
UniGeneiRn.22238

Genome annotation databases

EnsembliENSRNOT00000092207; ENSRNOP00000070832; ENSRNOG00000060869
GeneIDi363520
KEGGirno:363520

Similar proteinsi

Entry informationi

Entry nameiB2RYH5_RAT
AccessioniPrimary (citable) accession number: B2RYH5
Secondary accession number(s): F1LSW4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 18, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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