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Protein

Inactive heparanase-2

Gene

Hpse2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • extracellular matrix organization Source: MGI
  • positive regulation of cell proliferation Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-2024096 HS-GAG degradation

Protein family/group databases

CAZyiGH79 Glycoside Hydrolase Family 79

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive heparanase-2
Short name:
Hpa2
Gene namesi
Name:Hpse2
Synonyms:Hpa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2685814 Hpse2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 38Sequence analysisAdd BLAST38
ChainiPRO_000041888839 – 592Inactive heparanase-2Add BLAST554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi392N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiB2RY83
PRIDEiB2RY83

PTM databases

iPTMnetiB2RY83
PhosphoSitePlusiB2RY83

Expressioni

Gene expression databases

BgeeiENSMUSG00000074852 Expressed in 12 organ(s), highest expression level in colon

Interactioni

Subunit structurei

Interacts with HPSE. Interacts with SDC1 (via glycan chains) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097026

Structurei

3D structure databases

ProteinModelPortaliB2RY83
SMRiB2RY83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 79 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHNV Eukaryota
ENOG410YDJW LUCA
GeneTreeiENSGT00390000004874
HOGENOMiHOG000007256
HOVERGENiHBG081606
InParanoidiB2RY83
KOiK07965
OMAiHRNPDNS
OrthoDBiEOG091G05QD
PhylomeDBiB2RY83
TreeFamiTF328999

Family and domain databases

InterProiView protein in InterPro
IPR005199 Glyco_hydro_79
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR14363 PTHR14363, 1 hit
PfamiView protein in Pfam
PF03662 Glyco_hydro_79n, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2RY83-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVLCAFPEA MASSSSRPPS CLALVALFLA LLLHLSLSFH AGNRRPLPVD
60 70 80 90 100
RATGLKEKTL ILLDVSTKNP VRTVNENFLS LQLDPSIIHD GWLDFLSSKR
110 120 130 140 150
LVTLARGLSP AFLRFGGKRT DFLQFQNLRN PAKSRGGPGP DYYLKNYEDD
160 170 180 190 200
IVRSDVALDK QKGCKIAQHP DVMLELQREK ASQMHLVLLK EQYSNTYSNL
210 220 230 240 250
ILTARSLDKL YNFADCSGLH LIFALNALRR NPNNSWNSSS ALSLLKYSAS
260 270 280 290 300
KKYNISWELG NEPNNYRSIH GRAVNGSQLG KDYIQLKSLL QPIRVYSRAS
310 320 330 340 350
LYGPNIGRPR KNVIALLDGF MKVAGSTVDA VTWQHCYIDG RVVKVMDFLK
360 370 380 390 400
TRLLDTLSDQ IRKIQKVVNT YTPGKKIWLE GVVTTSAGGT NNLSDSYAAG
410 420 430 440 450
FLWLNTLGML ANQGIDVVIR HSFFDHGYNH LVDQNFNPLP DYWLSLLYKR
460 470 480 490 500
LIGPKVLAVH VAGLQRKPRP GRVIRDKLRI YAHCTNHHNH NYVRGSITLF
510 520 530 540 550
IINLHRSRKK IKLAGTLRDK LVHQYLLQPY GQEGLKSKSV QLNGQPLVMV
560 570 580 590
DDGTLPELKP RPLRAGRTLV IPPVTMGFYV VKNVNALACR YR
Length:592
Mass (Da):66,685
Last modified:July 1, 2008 - v1
Checksum:iC82F7A502B776E1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122312 Genomic DNA No translation available.
AC124716 Genomic DNA No translation available.
AC125458 Genomic DNA No translation available.
AC126795 Genomic DNA No translation available.
AC140375 Genomic DNA No translation available.
BC158131 mRNA Translation: AAI58132.1
BC158133 mRNA Translation: AAI58134.1
BC158136 mRNA Translation: AAI58137.1
CCDSiCCDS37993.1
RefSeqiNP_001074726.1, NM_001081257.2
UniGeneiMm.442200

Genome annotation databases

EnsembliENSMUST00000099428; ENSMUSP00000097026; ENSMUSG00000074852
GeneIDi545291
KEGGimmu:545291
UCSCiuc008hoe.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122312 Genomic DNA No translation available.
AC124716 Genomic DNA No translation available.
AC125458 Genomic DNA No translation available.
AC126795 Genomic DNA No translation available.
AC140375 Genomic DNA No translation available.
BC158131 mRNA Translation: AAI58132.1
BC158133 mRNA Translation: AAI58134.1
BC158136 mRNA Translation: AAI58137.1
CCDSiCCDS37993.1
RefSeqiNP_001074726.1, NM_001081257.2
UniGeneiMm.442200

3D structure databases

ProteinModelPortaliB2RY83
SMRiB2RY83
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097026

Protein family/group databases

CAZyiGH79 Glycoside Hydrolase Family 79

PTM databases

iPTMnetiB2RY83
PhosphoSitePlusiB2RY83

Proteomic databases

PaxDbiB2RY83
PRIDEiB2RY83

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099428; ENSMUSP00000097026; ENSMUSG00000074852
GeneIDi545291
KEGGimmu:545291
UCSCiuc008hoe.2 mouse

Organism-specific databases

CTDi60495
MGIiMGI:2685814 Hpse2

Phylogenomic databases

eggNOGiENOG410IHNV Eukaryota
ENOG410YDJW LUCA
GeneTreeiENSGT00390000004874
HOGENOMiHOG000007256
HOVERGENiHBG081606
InParanoidiB2RY83
KOiK07965
OMAiHRNPDNS
OrthoDBiEOG091G05QD
PhylomeDBiB2RY83
TreeFamiTF328999

Enzyme and pathway databases

ReactomeiR-MMU-2024096 HS-GAG degradation

Miscellaneous databases

PROiPR:B2RY83
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074852 Expressed in 12 organ(s), highest expression level in colon

Family and domain databases

InterProiView protein in InterPro
IPR005199 Glyco_hydro_79
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR14363 PTHR14363, 1 hit
PfamiView protein in Pfam
PF03662 Glyco_hydro_79n, 1 hit
SUPFAMiSSF51445 SSF51445, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHPSE2_MOUSE
AccessioniPrimary (citable) accession number: B2RY83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: July 1, 2008
Last modified: November 7, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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Main funding by: National Institutes of Health

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