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Entry version 104 (02 Jun 2021)
Sequence version 2 (06 Feb 2013)
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Protein

RNA-binding protein 25

Gene

Rbm25

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processApoptosis, mRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding protein 25
Alternative name(s):
RNA-binding motif protein 25
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rbm25
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914289, Rbm25

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003681871 – 838RNA-binding protein 25Add BLAST838

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei135N6-acetyllysineCombined sources1
Modified residuei225PhosphoserineBy similarity1
Modified residuei228PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki260Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki272Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki425Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki573Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei578PhosphoserineCombined sources1
Cross-linki666Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei672PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Cross-linki683Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki692Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei698PhosphoserineCombined sources1
Cross-linki717Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
B2RY56

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
B2RY56

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B2RY56

PeptideAtlas

More...
PeptideAtlasi
B2RY56

PRoteomics IDEntifications database

More...
PRIDEi
B2RY56

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
253181

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B2RY56

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
B2RY56

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000010608, Expressed in forelimb bud and 318 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
B2RY56, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
B2RY56, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LUC7L3 and SRRM1 (By similarity). Specifically associates with functional splicing complexes, including Sm proteins and U1, U2, U4, U5 and U6 snRNAs (By similarity). Associates with exon junction complex (EJC) proteins, including APEX1, DDX39B, NCBP1, RBM8A and RNPS1. Interaction with NCBP1 is RNA-dependent (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
211893, 17 interactors

Protein interaction database and analysis system

More...
IntActi
B2RY56, 4 interactors

Molecular INTeraction database

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MINTi
B2RY56

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000048470

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
B2RY56, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
B2RY56

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini87 – 164RRMPROSITE-ProRule annotationAdd BLAST78
Domaini745 – 838PWIPROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni173 – 201DisorderedSequence analysisAdd BLAST29
Regioni220 – 242DisorderedSequence analysisAdd BLAST23
Regioni282 – 437DisorderedSequence analysisAdd BLAST156
Regioni284 – 639Necessary for nuclear speckle localizationBy similarityAdd BLAST356
Regioni493 – 683DisorderedSequence analysisAdd BLAST191

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi227 – 242Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi493 – 575Basic and acidic residuesSequence analysisAdd BLAST83
Compositional biasi576 – 601Acidic residuesSequence analysisAdd BLAST26
Compositional biasi615 – 634Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PWI domain binds nucleic acids with significant help from its N-terminal flanking basic region. It has an equal preference for binding to single- or double-stranded species, and it contributes to RBM25 role in modulation of alternative splicing, maybe by mediating RNA-dependent association with LUC7L3 (By similarity).By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2253, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111019

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009855_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B2RY56

Database of Orthologous Groups

More...
OrthoDBi
885027at2759

TreeFam database of animal gene trees

More...
TreeFami
TF320185

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12446, RRM_RBM25, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR002483, PWI_dom
IPR036483, PWI_dom_sf
IPR035979, RBD_domain_sf
IPR034268, RBM25_RRM
IPR000504, RRM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01480, PWI, 1 hit
PF00076, RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00311, PWI, 1 hit
SM00360, RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101233, SSF101233, 1 hit
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51025, PWI, 1 hit
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

B2RY56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFPPHLNRP PMGIPALPPG IPPPQFPGFP PPVPPGTPMI PVPMSIMAPA
60 70 80 90 100
PTVLVPTVSM VGKHLGARKD HPGLKLKEND ENCGPTTTVF VGNISEKASD
110 120 130 140 150
MLIRQLLAKC GLVLSWKRVQ GASGKLQAFG FCEYKEPEST LRALRLLHDL
160 170 180 190 200
QIGEKKLLVK VDAKTKAQLD EWKAKKKANG NARPETVTND DEEALDEETK
210 220 230 240 250
RRDQMIKGAI EVLIREYSSE LNAPSQESDS HPRKKKKEKK EDIFRRFPVA
260 270 280 290 300
PLIPYPLITK EDINAIEMEE DKRDLISREI SKFRDTHKKL EEEKGKKEKE
310 320 330 340 350
RQEIEKERRE RERERERERE RRERERERER EREREKEKER ERERERDRDR
360 370 380 390 400
DRTKERDRDR ERDRDRDRER SSDRNKDRSR SREKSRDRER ERERERERER
410 420 430 440 450
ERERERERER ERERERERER EKDKKRDREE DEEDAYERRK LERKLREKEA
460 470 480 490 500
AYQERLKNWE IRERKKTREY EKEAEREEER RREMAKEAKR LKEFLEDYDD
510 520 530 540 550
DRDDPKYYRG SALQKRLRDR EKEMEADERD RKREKEELEE IRQRLLAEGH
560 570 580 590 600
PDPDAELQRM EQEAERRRQP QIKQEPESEE EEEEKQEKEE KREEPVEEEE
610 620 630 640 650
EPEQKPCLKP TLRPISSAPS VSSASGNATP NTPGDESPCG IIIPHENSPD
660 670 680 690 700
QQQPEEHRPK IGLSLKLGAS NSPGQPNSVK RKKLPVDSVF NKFEDEDSDD
710 720 730 740 750
VPRKRKLVPL DYGEDDKNAT KGTVNTEEKR KHIKSLIEKI PTAKPELFAY
760 770 780 790 800
PLDWSIVDSI LMERRIRPWI NKKIIEYIGE EEATLVDFVC SKVMAHSSPQ
810 820 830
SILDDVAMVL DEEAEVFIVK MWRLLIYETE AKKIGLVK
Length:838
Mass (Da):99,552
Last modified:February 6, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFD5D178EBDF12E23
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R2B0S4R2B0_MOUSE
RNA-binding protein 25
Rbm25
585Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2A4S4R2A4_MOUSE
RNA-binding protein 25
Rbm25
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2J1S4R2J1_MOUSE
RNA-binding protein 25
Rbm25
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1X9S4R1X9_MOUSE
RNA-binding protein 25
Rbm25
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2B1S4R2B1_MOUSE
RNA-binding protein 25
Rbm25
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1X5S4R1X5_MOUSE
RNA-binding protein 25
Rbm25
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2F7S4R2F7_MOUSE
RNA-binding protein 25
Rbm25
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2J4S4R2J4_MOUSE
RNA-binding protein 25
Rbm25
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH10792 differs from that shown. Probable cloning artifact.Curated
The sequence AAH10792 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH66150 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAH67400 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI58105 differs from that shown. Aberrant splicing.Curated
The sequence BAB27451 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAE24941 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti487E → G in BAB27451 (PubMed:16141072).Curated1
Sequence conflicti578S → F in AAH66150 (PubMed:15489334).Curated1
Sequence conflicti578S → F in AAH67400 (PubMed:15489334).Curated1
Sequence conflicti618A → D in BAB27451 (PubMed:16141072).Curated1
Sequence conflicti666K → R in BAB27451 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK011184 mRNA Translation: BAB27451.2 Different initiation.
AK011403 mRNA Translation: BAB27595.3
AK076553 mRNA Translation: BAC36389.1
AK142132 mRNA Translation: BAE24941.1 Different initiation.
AK151910 mRNA Translation: BAE30791.1
AK164367 mRNA Translation: BAE37760.1
BC158104 mRNA Translation: AAI58105.1 Sequence problems.
BC010792 mRNA Translation: AAH10792.1 Sequence problems.
BC066150 mRNA Translation: AAH66150.1 Different initiation.
BC067400 mRNA Translation: AAH67400.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS49107.1

NCBI Reference Sequences

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RefSeqi
NP_081625.3, NM_027349.3
XP_006516230.1, XM_006516167.3
XP_006516231.1, XM_006516168.3
XP_006516232.1, XM_006516169.3
XP_017170651.1, XM_017315162.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000048155; ENSMUSP00000048470; ENSMUSG00000010608

Database of genes from NCBI RefSeq genomes

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GeneIDi
67039

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:67039

UCSC genome browser

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UCSCi
uc007odj.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011184 mRNA Translation: BAB27451.2 Different initiation.
AK011403 mRNA Translation: BAB27595.3
AK076553 mRNA Translation: BAC36389.1
AK142132 mRNA Translation: BAE24941.1 Different initiation.
AK151910 mRNA Translation: BAE30791.1
AK164367 mRNA Translation: BAE37760.1
BC158104 mRNA Translation: AAI58105.1 Sequence problems.
BC010792 mRNA Translation: AAH10792.1 Sequence problems.
BC066150 mRNA Translation: AAH66150.1 Different initiation.
BC067400 mRNA Translation: AAH67400.1 Different initiation.
CCDSiCCDS49107.1
RefSeqiNP_081625.3, NM_027349.3
XP_006516230.1, XM_006516167.3
XP_006516231.1, XM_006516168.3
XP_006516232.1, XM_006516169.3
XP_017170651.1, XM_017315162.1

3D structure databases

SMRiB2RY56
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi211893, 17 interactors
IntActiB2RY56, 4 interactors
MINTiB2RY56
STRINGi10090.ENSMUSP00000048470

PTM databases

iPTMnetiB2RY56
PhosphoSitePlusiB2RY56

Proteomic databases

EPDiB2RY56
jPOSTiB2RY56
PaxDbiB2RY56
PeptideAtlasiB2RY56
PRIDEiB2RY56
ProteomicsDBi253181

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
158, 60 antibodies

The DNASU plasmid repository

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DNASUi
67039

Genome annotation databases

EnsembliENSMUST00000048155; ENSMUSP00000048470; ENSMUSG00000010608
GeneIDi67039
KEGGimmu:67039
UCSCiuc007odj.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
58517
MGIiMGI:1914289, Rbm25

Phylogenomic databases

eggNOGiKOG2253, Eukaryota
GeneTreeiENSGT00730000111019
HOGENOMiCLU_009855_0_0_1
InParanoidiB2RY56
OrthoDBi885027at2759
TreeFamiTF320185

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
67039, 25 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Rbm25, mouse

Protein Ontology

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PROi
PR:B2RY56
RNActiB2RY56, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000010608, Expressed in forelimb bud and 318 other tissues
ExpressionAtlasiB2RY56, baseline and differential
GenevisibleiB2RY56, MM

Family and domain databases

CDDicd12446, RRM_RBM25, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR002483, PWI_dom
IPR036483, PWI_dom_sf
IPR035979, RBD_domain_sf
IPR034268, RBM25_RRM
IPR000504, RRM_dom
PfamiView protein in Pfam
PF01480, PWI, 1 hit
PF00076, RRM_1, 1 hit
SMARTiView protein in SMART
SM00311, PWI, 1 hit
SM00360, RRM, 1 hit
SUPFAMiSSF101233, SSF101233, 1 hit
SSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51025, PWI, 1 hit
PS50102, RRM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBM25_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2RY56
Secondary accession number(s): Q3TPH6
, Q3U976, Q3UQU7, Q6NWW2, Q8BVT8, Q91XE6, Q9CT27, Q9CT49
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 6, 2013
Last modified: June 2, 2021
This is version 104 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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