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Protein

Dedicator of cytokinesis protein 5

Gene

Dock5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (PubMed:18396277). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-983231 Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dedicator of cytokinesis protein 5By similarity
Alternative name(s):
Lens rupture protein 2
Rupture of lens cataract protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dock5Imported
Synonyms:Lr21 Publication, Rlc1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2652871 Dock5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Dock5 are the cause of rupture of lens cataract. It affects both eyes and is inherited as an autosomal recessive trait. Homozygotes spontaneously develop opacity of the lens at 35-60 days of age. The initial pathological changes appear at about 35 days of age in the deep layer of the posterior cortex as irregular swelling, condensation, degeneration and fragmentation of the lens fibers, leading to rupture of the lens capsule at the posterior pole at 45-100 days of age. Following rupture, the lens nucleus becomes dislocated behind the lens or occasionally in the anterior chamber.2 Publications

Keywords - Diseasei

Cataract

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003588581 – 1868Dedicator of cytokinesis protein 5Add BLAST1868

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei365PhosphoserineBy similarity1
Modified residuei818N6-acetyllysineBy similarity1
Modified residuei1755PhosphoserineBy similarity1
Modified residuei1765PhosphoserineBy similarity1
Modified residuei1771PhosphoserineBy similarity1
Modified residuei1784PhosphoserineBy similarity1
Modified residuei1788PhosphoserineBy similarity1
Modified residuei1793PhosphothreonineBy similarity1
Modified residuei1832PhosphoserineBy similarity1
Modified residuei1867PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
B2RY04

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
B2RY04

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B2RY04

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B2RY04

PeptideAtlas

More...
PeptideAtlasi
B2RY04

PRoteomics IDEntifications database

More...
PRIDEi
B2RY04

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B2RY04

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
B2RY04

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in lens, where it predominantly localizes to anterior epithelial cells, and is weakly expressed in lens fiber (at protein level). Expressed in brain, eye, lung, spleen and kidney, but not in thymus or peripheral blood leukocytes.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In the lens, expressed from E15.5 to maturity.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000044447 Expressed in 247 organ(s), highest expression level in lens of camera-type eye

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
B2RY04 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CRK and CRKL.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000036674

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
B2RY04

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B2RY04

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 69SH3PROSITE-ProRule annotationAdd BLAST62
Domaini443 – 627DHR-1PROSITE-ProRule annotationAdd BLAST185
Domaini1231 – 1642DHR-2PROSITE-ProRule annotationAdd BLAST412

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1775 – 1853Pro-richSequence analysisAdd BLAST79

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DHR-2 domain may mediate some GEF activity.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1998 Eukaryota
ENOG410XQH7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157734

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006631

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051389

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
B2RY04

KEGG Orthology (KO)

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KOi
K17707

Identification of Orthologs from Complete Genome Data

More...
OMAi
MEMSDNE

Database of Orthologous Groups

More...
OrthoDBi
102580at2759

TreeFam database of animal gene trees

More...
TreeFami
TF300423

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR032376 DOCK_N
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23317 PTHR23317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF16172 DOCK_N, 1 hit
PF00018 SH3_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B2RY04-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARWIPTKRQ KYGVAIYNYN ASQDVELSLQ IGDTVHILEM YEGWYRGYAL
60 70 80 90 100
QNRSKKGIFP ETYIHLKEAT VEDGGQHETV IPGELPLVQE LTNTLREWAV
110 120 130 140 150
IWRKLYVNNK VTLFRQLQQM TYSLIEWRSQ ILSGTLPKDE LAELKKKVTA
160 170 180 190 200
KIDHGNRMLG LDLVVRDDNG NILDPDETST VALFRAHEVA SKRIEEKIQE
210 220 230 240 250
EKSILQNLDL RGQAIFSTVH TYGLYVNFKN FVCNIGEDAE LFIALYDPDQ
260 270 280 290 300
STFISENYLI RWGSNGMPKE IEKLNNLQAV FTDLSSTDLI RPRISLVCQI
310 320 330 340 350
VRVGRMELKE GKKHTCGLRR PFGVAVMDIS DIVHGKVDDE EKQHFIPFQQ
360 370 380 390 400
IAMETYIRQR QLIMSPLITS HVIGENEPLT SVLNKVIAAK EVNHKGQGLW
410 420 430 440 450
VSLKLLPGDL TQVQKNFSHL VDRSTAIARK MGFPEIILPG DVRNDIYVTL
460 470 480 490 500
IHGEFDKGKK KTPKNVEVTM SVFDEEGNLL EKAIHPGAGY EGVSEYKSVV
510 520 530 540 550
YYQVKQPCWY ETVKVFIAIE EVTRCHIRFT FRHRSSQESR DKSERAFGVA
560 570 580 590 600
FVKLMNADGT TLQDGRHDLV VYKGDNKKME DAKYYLTLPG TKAELEEKEL
610 620 630 640 650
QASKNPSVFT PSKDSTKDSF QIATLICSTK LTQNVDLLGL LNWRSNSQNI
660 670 680 690 700
KHNLKKLMEV DGGEIVKFLQ DTLDALFNIM MEMSDNETYD FLVFDALVFI
710 720 730 740 750
ISLIGDIKFQ HFNPVLETYI YKHFSATLAH VKLSKVLNFY VANAEDPSKT
760 770 780 790 800
ELLFAALKAL KYLFRFIIQS RVLYLRFYGQ SEDGDEFNDS IRQLFLAFNT
810 820 830 840 850
LMDRPLEEAV KIKGAALKYL PSIINDVKLV FDPMELSVLF CKFIQSIPDN
860 870 880 890 900
QLVRQKLNCM TKIVESSLFQ QAECREVLLP LLTDQLSGQL DDHSTKPDHE
910 920 930 940 950
ASSQLLSNIL EVLDRTDVGP TSAHVQLIME RLLRRINRTV IGMSRQSPHI
960 970 980 990 1000
GSFVACMIAV LRQMEDSHYS HYISTFKTRQ DIIDFLMETF IMFKDLIGKN
1010 1020 1030 1040 1050
VYAKDWMVMN MTQNRVFLRA INQFAEVLTK SFMDQASFEL QLWNNYFHLA
1060 1070 1080 1090 1100
VAFLTHESLQ LETFSEAKRN KIVKKYGDMR KEIGFRIRDM WYNLGPHKIK
1110 1120 1130 1140 1150
FIPSMVGPIL EVTLTPEVEL RKATIPIFFD MMQCEFNLSG NGNFHMFENE
1160 1170 1180 1190 1200
LITKLDQEVE GGRGDEQYKV LLEKLLLEHC RKHKYLANSG EAFAFLVSSL
1210 1220 1230 1240 1250
LENLLDYRTI IIHDESKENR MSCTVNVLNF YKDKKREDIY IRYLYKLRDL
1260 1270 1280 1290 1300
HRDCENYTEA AYTLLLHAEL LQWSDKPCVP HLLQRDSYYV YTQQELKEKL
1310 1320 1330 1340 1350
YQEIISYFDK GKMWEKAIKL SKELAETYES KVFDYEGLGS LLKKRALFYE
1360 1370 1380 1390 1400
NIIKAMRPQP EYFAVGYYGQ GFPSFLRNKI FIYRGKEYER REDFSLRLLT
1410 1420 1430 1440 1450
QFPNAEKMTS TTPPGEDIKS SPKQYLQCFT VKPVMSLPPS YKDKPVPEQI
1460 1470 1480 1490 1500
LNYYRANEVQ QFSYSRPFRK GEKDPENEFA TMWIERTTYR TAYTFPGILK
1510 1520 1530 1540 1550
WFEAKEISVE EISPLENAIE TMELTNERVS NCVQQHAWDH SLSVHPLSML
1560 1570 1580 1590 1600
LSGIVDPAVM GGFSNYEKAF FTEKYLQEHP EDQEKVELLK RLIALQIPLL
1610 1620 1630 1640 1650
TEGIRIHGEK LTEQLKPLHA RLSSCFRELK EKVEKLYGVI TLPPSMTERK
1660 1670 1680 1690 1700
PSRAGSMVLP YILSSTLRRL SVTSVASSVI STSSNSSDNA SSRPGSDGSI
1710 1720 1730 1740 1750
LEPLFERRAS SGARVEDLPP KEDSENRISK FKRKDWNLSK SQVIAEKAPE
1760 1770 1780 1790 1800
PDVMSPGKKT QRPKSLQLVD SRLTPFHSPS PLQSTALSPP PLTPKATRTL
1810 1820 1830 1840 1850
SSPSLQTDGL TASVPPPPPP KSKPYESSQR NSAEIAPPLP VRRDSKAPPP
1860
PPPKARKSGI LSSEPGSQ
Length:1,868
Mass (Da):214,429
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4AB0D8CD588F73D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti49A → R in AAI58047 (PubMed:15489334).Curated1
Sequence conflicti49A → R in AAI58136 (PubMed:15489334).Curated1
Sequence conflicti49A → R in AAI58139 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC090431 Genomic DNA No translation available.
AC093020 Genomic DNA No translation available.
BC158046 mRNA Translation: AAI58047.1
BC158135 mRNA Translation: AAI58136.1
BC158138 mRNA Translation: AAI58139.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36963.1

NCBI Reference Sequences

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RefSeqi
NP_808448.2, NM_177780.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.258155

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000039135; ENSMUSP00000036674; ENSMUSG00000044447

Database of genes from NCBI RefSeq genomes

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GeneIDi
68813

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:68813

UCSC genome browser

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UCSCi
uc007ull.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090431 Genomic DNA No translation available.
AC093020 Genomic DNA No translation available.
BC158046 mRNA Translation: AAI58047.1
BC158135 mRNA Translation: AAI58136.1
BC158138 mRNA Translation: AAI58139.1
CCDSiCCDS36963.1
RefSeqiNP_808448.2, NM_177780.3
UniGeneiMm.258155

3D structure databases

ProteinModelPortaliB2RY04
SMRiB2RY04
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036674

PTM databases

iPTMnetiB2RY04
PhosphoSitePlusiB2RY04

Proteomic databases

EPDiB2RY04
jPOSTiB2RY04
MaxQBiB2RY04
PaxDbiB2RY04
PeptideAtlasiB2RY04
PRIDEiB2RY04

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039135; ENSMUSP00000036674; ENSMUSG00000044447
GeneIDi68813
KEGGimmu:68813
UCSCiuc007ull.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80005
MGIiMGI:2652871 Dock5

Phylogenomic databases

eggNOGiKOG1998 Eukaryota
ENOG410XQH7 LUCA
GeneTreeiENSGT00940000157734
HOGENOMiHOG000006631
HOVERGENiHBG051389
InParanoidiB2RY04
KOiK17707
OMAiMEMSDNE
OrthoDBi102580at2759
TreeFamiTF300423

Enzyme and pathway databases

ReactomeiR-MMU-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Dock5 mouse

Protein Ontology

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PROi
PR:B2RY04

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000044447 Expressed in 247 organ(s), highest expression level in lens of camera-type eye
GenevisibleiB2RY04 MM

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR032376 DOCK_N
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF16172 DOCK_N, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00326 SH3, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDOCK5_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2RY04
Secondary accession number(s): E9QLI4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 27, 2011
Last modified: January 16, 2019
This is version 79 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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