Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Feline leukemia virus subgroup C receptor-related protein 1

Gene

Flvcr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro.By similarity1 Publication
Isoform 2: Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation.

GO - Molecular functioni

  • heme binding Source: GO_Central
  • heme transporter activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processErythrocyte maturation, Transport

Enzyme and pathway databases

ReactomeiR-MMU-917937 Iron uptake and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Feline leukemia virus subgroup C receptor-related protein 1
Short name:
Feline leukemia virus subgroup C receptor
Alternative name(s):
Major facilitator superfamily domain containing 7B
Short name:
Mfsd7b
Gene namesi
Name:Flvcr1
Synonyms:Mfsd7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2444881 Flvcr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 100CytoplasmicSequence analysisAdd BLAST100
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Topological domaini122 – 140ExtracellularSequence analysisAdd BLAST19
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 167CytoplasmicSequence analysis6
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 192ExtracellularSequence analysis4
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Topological domaini214 – 233CytoplasmicSequence analysisAdd BLAST20
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 280ExtracellularSequence analysisAdd BLAST26
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 336CytoplasmicSequence analysisAdd BLAST35
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Topological domaini358 – 377ExtracellularSequence analysisAdd BLAST20
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Topological domaini399 – 406CytoplasmicSequence analysis8
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Topological domaini428 – 429ExtracellularSequence analysis2
Transmembranei430 – 450HelicalSequence analysisAdd BLAST21
Topological domaini451 – 464CytoplasmicSequence analysisAdd BLAST14
Transmembranei465 – 485HelicalSequence analysisAdd BLAST21
Topological domaini486 – 496ExtracellularSequence analysisAdd BLAST11
Transmembranei497 – 517HelicalSequence analysisAdd BLAST21
Topological domaini518 – 560CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell membrane, Membrane, Mitochondrion

Pathology & Biotechi

Disruption phenotypei

Lack definitive erythropoiesis, have craniofacial and limb deformities, and die in midgestation. Mice with FLVCR1 that is deleted neonatally develop a severe macrocytic anemia with proerythroblast maturation arrest. Mice lacking the plasma membrane isoform (Flvcr1a) but expressing Flvcr1b had normal erythropoiesis, but exhibited hemorrhages, edema, and skeletal abnormalities.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004234241 – 560Feline leukemia virus subgroup C receptor-related protein 1Add BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi270N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei542PhosphoserineBy similarity1

Post-translational modificationi

N-Glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiB2RXV4
MaxQBiB2RXV4
PaxDbiB2RXV4
PeptideAtlasiB2RXV4
PRIDEiB2RXV4

PTM databases

iPTMnetiB2RXV4
PhosphoSitePlusiB2RXV4

Expressioni

Gene expression databases

BgeeiENSMUSG00000066595 Expressed in 235 organ(s), highest expression level in small intestine
ExpressionAtlasiB2RXV4 baseline and differential
GenevisibleiB2RXV4 MM

Interactioni

Subunit structurei

Interacts with HPX.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082777

Structurei

3D structure databases

ProteinModelPortaliB2RXV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2563 Eukaryota
ENOG410XSTK LUCA
GeneTreeiENSGT00530000062892
HOGENOMiHOG000019717
HOVERGENiHBG051631
InParanoidiB2RXV4
KOiK08220
OMAiYVSFIGQ
OrthoDBiEOG091G0FJM
PhylomeDBiB2RXV4
TreeFamiTF314292

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: B2RXV4-1) [UniParc]FASTAAdd to basket
Also known as: Flvcr1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARPDDEVGP AVAPGHPLGK GYLPVPKGAP DGEARLVPQN GPEALNGGPG
60 70 80 90 100
LGPLIAGAQG GPQALIAAEE ETQARLLPAG DGEDVPCPAC PPRTALSPRR
110 120 130 140 150
FVVLLIFSLY SLVNAFQWIQ YSSISNVFED FYEVSPLHIN WLSMVYMVAY
160 170 180 190 200
VPLIFPATWL LDTRGLRLTA LLGSGLNCLG AWVKCGSVQR HLFWVTMLGQ
210 220 230 240 250
ILCSVAQVFI LGLPSPVASV WFGPKEVSTA CATAVLGNQL GTAVGFLLPP
260 270 280 290 300
VLVPALGTQN STGLLAHTQN NTDLLAHNIN TMFYGTAFIS TFLFFLTIIA
310 320 330 340 350
FKEKPPLPPS QAQAVLRDSP PEEYSYKSSI WNLCRNIPFV LLLVSYGIMT
360 370 380 390 400
GAFYSISTLL NQIILTYYVG EEVNAGRIGL TLVVAGMVGS ILCGLWLDYT
410 420 430 440 450
KTYKQTTLIV YVLSFIGMLI FTFTLNLGYI IVVFFTGGIL GFFMTGYLPL
460 470 480 490 500
GFEFAVEITY PESEGMSSGL LNTAAQILGI FFTLAQGKIT TDYNSPEAGN
510 520 530 540 550
IFLCAWMFVG IILTALIKSD LRRHNINTGL TNIDVKAVPV DSRVDPKPKV
560
MVSIQSESSL
Length:560
Mass (Da):60,469
Last modified:July 1, 2008 - v1
Checksum:i2FD8691D8E55BE52
GO
Isoform 2 (identifier: B2RXV4-2) [UniParc]FASTAAdd to basket
Also known as: Flvcr1b, mitochondrial

The sequence of this isoform differs from the canonical sequence as follows:
     1-281: Missing.

Note: Has a probable mitochondrial transit peptide at positions 1-38.
Show »
Length:279
Mass (Da):30,838
Checksum:i1A289900C1085AF9
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A6YWJ7A0A0A6YWJ7_MOUSE
Feline leukemia virus subgroup C re...
Flvcr1 Mfsd7b
246Annotation score:
A0A0A6YXG8A0A0A6YXG8_MOUSE
Feline leukemia virus subgroup C re...
Flvcr1 Mfsd7b
246Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0478671 – 281Missing in isoform 2. CuratedAdd BLAST281

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138229 Genomic DNA No translation available.
BC157992 mRNA Translation: AAI57993.1
CCDSiCCDS35823.1 [B2RXV4-1]
RefSeqiNP_001074728.1, NM_001081259.1 [B2RXV4-1]
NP_001300676.1, NM_001313747.1
UniGeneiMm.134053
Mm.472263

Genome annotation databases

EnsembliENSMUST00000085635; ENSMUSP00000082777; ENSMUSG00000066595 [B2RXV4-1]
GeneIDi226844
KEGGimmu:226844
UCSCiuc007ebv.1 mouse [B2RXV4-1]
uc011wyn.1 mouse [B2RXV4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138229 Genomic DNA No translation available.
BC157992 mRNA Translation: AAI57993.1
CCDSiCCDS35823.1 [B2RXV4-1]
RefSeqiNP_001074728.1, NM_001081259.1 [B2RXV4-1]
NP_001300676.1, NM_001313747.1
UniGeneiMm.134053
Mm.472263

3D structure databases

ProteinModelPortaliB2RXV4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000082777

PTM databases

iPTMnetiB2RXV4
PhosphoSitePlusiB2RXV4

Proteomic databases

EPDiB2RXV4
MaxQBiB2RXV4
PaxDbiB2RXV4
PeptideAtlasiB2RXV4
PRIDEiB2RXV4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085635; ENSMUSP00000082777; ENSMUSG00000066595 [B2RXV4-1]
GeneIDi226844
KEGGimmu:226844
UCSCiuc007ebv.1 mouse [B2RXV4-1]
uc011wyn.1 mouse [B2RXV4-2]

Organism-specific databases

CTDi28982
MGIiMGI:2444881 Flvcr1

Phylogenomic databases

eggNOGiKOG2563 Eukaryota
ENOG410XSTK LUCA
GeneTreeiENSGT00530000062892
HOGENOMiHOG000019717
HOVERGENiHBG051631
InParanoidiB2RXV4
KOiK08220
OMAiYVSFIGQ
OrthoDBiEOG091G0FJM
PhylomeDBiB2RXV4
TreeFamiTF314292

Enzyme and pathway databases

ReactomeiR-MMU-917937 Iron uptake and transport

Miscellaneous databases

PROiPR:B2RXV4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066595 Expressed in 235 organ(s), highest expression level in small intestine
ExpressionAtlasiB2RXV4 baseline and differential
GenevisibleiB2RXV4 MM

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR011701 MFS
IPR020846 MFS_dom
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFLVC1_MOUSE
AccessioniPrimary (citable) accession number: B2RXV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: July 1, 2008
Last modified: November 7, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again