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Protein

Plexin-B2

Gene

Plxnb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • semaphorin receptor activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Plexin-B2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Plxnb2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:2154239 Plxnb2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 1201ExtracellularSequence analysisAdd BLAST1182
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1202 – 1222HelicalSequence analysisAdd BLAST21
Topological domaini1223 – 1842CytoplasmicSequence analysisAdd BLAST620

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic and perinatal lethality, due to defects in brain and neural tube development. Mice exhibit abnormal cortical layering and defective migration and differentiation of several subtypes of cortical neurons. Cranial neural folds fail to converge in most embryos, leading to an open neural tube and exencephaly. Likewise, mice exhibit defects in the embryonic development of the cerebellum and the olfactory bulb.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000041571020 – 1842Plexin-B2Add BLAST1823

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi78 ↔ 87PROSITE-ProRule annotation
Disulfide bondi112 ↔ 120PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi250 ↔ 366PROSITE-ProRule annotation
Disulfide bondi266 ↔ 313PROSITE-ProRule annotation
Disulfide bondi331 ↔ 353PROSITE-ProRule annotation
Glycosylationi393N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi451N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi471 ↔ 488PROSITE-ProRule annotation
Disulfide bondi477 ↔ 520PROSITE-ProRule annotation
Disulfide bondi480 ↔ 497PROSITE-ProRule annotation
Disulfide bondi491 ↔ 503PROSITE-ProRule annotation
Disulfide bondi557 ↔ 576PROSITE-ProRule annotation
Glycosylationi798N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi919N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1053N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1072N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1240PhosphoserineCombined sources1
Modified residuei1248PhosphoserineCombined sources1
Modified residuei1574PhosphoserineCombined sources1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1168 – 1169Cleavage; by proprotein convertasesBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
B2RXS4

MaxQB - The MaxQuant DataBase

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MaxQBi
B2RXS4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B2RXS4

PeptideAtlas

More...
PeptideAtlasi
B2RXS4

PRoteomics IDEntifications database

More...
PRIDEi
B2RXS4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B2RXS4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
B2RXS4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
B2RXS4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in macrophages from spleen and bone marrow (at protein level). Detected in granule cells in the developing cerebellum, dentate gyrus and olfactory bulb.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSMUSG00000036606 Expressed in 326 organ(s), highest expression level in pyloric antrum

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
B2RXS4 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer, and heterodimer with PLXNB1. Binds MET, ARHGEF11 and ARHGEF12. May also interact with MST1R (By similarity). Interacts with SEMA4C, SEMA4D and SEMA4G.By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Arhgef11Q68FM72EBI-8496724,EBI-2365869

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
228283, 2 interactors

Protein interaction database and analysis system

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IntActi
B2RXS4, 1 interactor

Molecular INTeraction database

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MINTi
B2RXS4

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000051731

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11842
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E6PX-ray3.21A1226-1842[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
B2RXS4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
B2RXS4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 468SemaPROSITE-ProRule annotationAdd BLAST449
Domaini806 – 895IPT/TIG 1Add BLAST90
Domaini898 – 982IPT/TIG 2Add BLAST85
Domaini986 – 1095IPT/TIG 3Add BLAST110

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410KCS6 Eukaryota
ENOG411131Q LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153516

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231376

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053404

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
B2RXS4

KEGG Orthology (KO)

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KOi
K06821

Identification of Orthologs from Complete Genome Data

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OMAi
EDSCPQF

Database of Orthologous Groups

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OrthoDBi
90434at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
B2RXS4

TreeFam database of animal gene trees

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TreeFami
TF312962

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR22625 PTHR22625, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51004 SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

B2RXS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPLWALTF LGLTGLGLSL RSRKPESFRS ETELNHLAVD EVTGVVYVGA
60 70 80 90 100
VNALYQLSAD LHVQQHVVTG PFMDNKKCTP PIEASQCHEA VLTDNFNQLL
110 120 130 140 150
LLDPPGKRLV ECGSLFKGIC ALRAMSNISV RLFYEDGSGE KSFVASNDER
160 170 180 190 200
VATVGLVTST RPDGERVLFV GKGNGPHDNG IIVSTRLLDR AEGREAFEAY
210 220 230 240 250
SDHTTFKAGY LSTNTQQFVA AFEDDFYVFF VFNHQDKHPA KNRTLLARMC
260 270 280 290 300
KDDPSYYSYV EMDLQCQDPS DPQDSAFGTC LAASVATSGA GRALYAVFSR
310 320 330 340 350
DGRSTGGPGA GLCVFPLDKV REKIEANRNA CYTGAREAGR TIFYKPFHGE
360 370 380 390 400
IQCGGHLIGA SESFPCGSEH LPYPLGSRDG LVATAVLHRG GLNLTAVTVT
410 420 430 440 450
AENDHTVAFL GTSDGRILKV YLAPDGTSAE YGSIPVDINK KIKQDLALSG
460 470 480 490 500
NLSSLYAMTQ DKVFRLPVQE CLSYVTCAQC RDSQDPYCGW CVIEGRCTRK
510 520 530 540 550
SECSRAEETG HWLWSREKSC VAITDAFPQN MSRRAQGEVR LSVSPLPTLT
560 570 580 590 600
EDDELLCLFG DSPPHPARVE DDTVICNSPS SIPSTPPGQD HVDVSIQLLL
610 620 630 640 650
KSGSVFLTSH QYPFYDCREA MSLVENLPCI SCASNRWTCQ WDLQYYECRE
660 670 680 690 700
ASPNPEEGII RAHMEDNCPQ FLAPDPLVIP MNHETEVTFQ GKNLETVKVS
710 720 730 740 750
SLYVGSELLN FEETVTMHES DTFSFRTPKL SHDGNETLPL HLYVKSFGKN
760 770 780 790 800
IDSKLQVTLY NCSFGRSDCS LCLAADPAYR CVWCRGQNRC VYEALCSNVT
810 820 830 840 850
SECPPPVITR IQPETGPLGG GILVTIHGSN LGVKADDVKK ITVAGQNCAF
860 870 880 890 900
EPRGYSVSTR IVCAIEASEM PFTGGIEVDV NGKLGHSPPH VQFTYQQPQP
910 920 930 940 950
LSVEPRQGPQ AGGTTLTING THLDTGSKED VRVTLNDVPC EVTKFGAQLQ
960 970 980 990 1000
CVTGQQLAPG QVTLEIYYGG SRVPSPGISF TYCENPMIRA FEPLRSFVSG
1010 1020 1030 1040 1050
GRSINVTGQG FSLIQKFAMV VIAEPLRSWR RRRREAGALE RVTVEGMEYV
1060 1070 1080 1090 1100
FYNDTKVVFL SPAVPEEPEA YNLTVLIRMD GHCAPLRTEA GVFEYVADPT
1110 1120 1130 1140 1150
FENFTGGVKK QVNKLIHARG TNLNKAMTLE EAEAFVGAER CIMKTLTETD
1160 1170 1180 1190 1200
LYCEPPEVQP PPKRRQKRDT AHNLPEFIVK FGSREWVLGR VEYDTRASDV
1210 1220 1230 1240 1250
PLSLILPLVM VPMVFIIVVS IYCYWRKSQQ AEREYEKIKS QLEGLEESVR
1260 1270 1280 1290 1300
DRCKKEFTDL MIEMEDQTND VHEAGIPTLD YKTYTDRVFF LPSKDGDKDV
1310 1320 1330 1340 1350
MITGKLDIPE SRRPIVEQAL YQFSNLLNSK SFLINFIHTL ENQREFSARA
1360 1370 1380 1390 1400
KVYFASLLTV ALHGKLEYYT DIMRTLFLEL MEQYVVAKNP KLMLRRSETV
1410 1420 1430 1440 1450
VERMLSNWMS ICLYQYLKDS AGEPLYKLFK AIKHQVEKGP VDAVQKKAKY
1460 1470 1480 1490 1500
TLNDTGLLGD DVEYAPLTVS VIVQDEGIDA IPVKVLNCDT ISQVKEKIID
1510 1520 1530 1540 1550
QVYRTQPCSC WPKPDSVVLE WRPGSTAQIL SDLDLTSQRE GRWKRINTLM
1560 1570 1580 1590 1600
HYNVRDGATL ILSKVGVSQQ PEDSQQDLPG ERHALLEEEN RVWHLVRPTD
1610 1620 1630 1640 1650
EVDEGKSKRG SMKEKERTKA ITEIYLTRLL SVKGTLQQFV DNFFQSVLAP
1660 1670 1680 1690 1700
GHAVPPAVKY FFDFLDEQAE KHDIRDEDTI HIWKTNSLPL RFWVNILKNP
1710 1720 1730 1740 1750
HFIFDVHVHE VVDASLSVIA QTFMDACTRT EHKLSRDSPS NKLLYAKEIS
1760 1770 1780 1790 1800
TYKKMVEDYY KGIRQMVQVS DQDMNTHLAE ISRAHTDSLN TLVALHQLYQ
1810 1820 1830 1840
YTQKYYDEII NALEEDPAAQ KMQLAFRLQQ IAAALENKVT DL
Length:1,842
Mass (Da):206,230
Last modified:July 1, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D445E7354C107FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1382E → G in BAE27981 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK147538 mRNA Translation: BAE27981.1
AC113069 Genomic DNA No translation available.
AC160538 Genomic DNA No translation available.
CH466550 Genomic DNA Translation: EDL04367.1
BC157960 mRNA Translation: AAI57961.1
BC157961 mRNA Translation: AAI57962.1
BC158086 mRNA Translation: AAI58087.1
BC172162 mRNA Translation: AAI72162.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS49698.1

NCBI Reference Sequences

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RefSeqi
NP_001152993.1, NM_001159521.2
NP_001271435.1, NM_001284506.1
NP_620088.2, NM_138749.3
XP_006520475.1, XM_006520412.1
XP_006520476.1, XM_006520413.1
XP_011243751.1, XM_011245449.1
XP_011243752.1, XM_011245450.2
XP_011243753.1, XM_011245451.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.267514

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000060808; ENSMUSP00000051731; ENSMUSG00000036606
ENSMUST00000109331; ENSMUSP00000104955; ENSMUSG00000036606

Database of genes from NCBI RefSeq genomes

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GeneIDi
140570

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:140570

UCSC genome browser

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UCSCi
uc007xfr.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK147538 mRNA Translation: BAE27981.1
AC113069 Genomic DNA No translation available.
AC160538 Genomic DNA No translation available.
CH466550 Genomic DNA Translation: EDL04367.1
BC157960 mRNA Translation: AAI57961.1
BC157961 mRNA Translation: AAI57962.1
BC158086 mRNA Translation: AAI58087.1
BC172162 mRNA Translation: AAI72162.1
CCDSiCCDS49698.1
RefSeqiNP_001152993.1, NM_001159521.2
NP_001271435.1, NM_001284506.1
NP_620088.2, NM_138749.3
XP_006520475.1, XM_006520412.1
XP_006520476.1, XM_006520413.1
XP_011243751.1, XM_011245449.1
XP_011243752.1, XM_011245450.2
XP_011243753.1, XM_011245451.2
UniGeneiMm.267514

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5E6PX-ray3.21A1226-1842[»]
ProteinModelPortaliB2RXS4
SMRiB2RXS4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228283, 2 interactors
IntActiB2RXS4, 1 interactor
MINTiB2RXS4
STRINGi10090.ENSMUSP00000051731

PTM databases

iPTMnetiB2RXS4
PhosphoSitePlusiB2RXS4
SwissPalmiB2RXS4

Proteomic databases

jPOSTiB2RXS4
MaxQBiB2RXS4
PaxDbiB2RXS4
PeptideAtlasiB2RXS4
PRIDEiB2RXS4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000060808; ENSMUSP00000051731; ENSMUSG00000036606
ENSMUST00000109331; ENSMUSP00000104955; ENSMUSG00000036606
GeneIDi140570
KEGGimmu:140570
UCSCiuc007xfr.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23654
MGIiMGI:2154239 Plxnb2

Phylogenomic databases

eggNOGiENOG410KCS6 Eukaryota
ENOG411131Q LUCA
GeneTreeiENSGT00940000153516
HOGENOMiHOG000231376
HOVERGENiHBG053404
InParanoidiB2RXS4
KOiK06821
OMAiEDSCPQF
OrthoDBi90434at2759
PhylomeDBiB2RXS4
TreeFamiTF312962

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Plxnb2 mouse

Protein Ontology

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PROi
PR:B2RXS4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036606 Expressed in 326 organ(s), highest expression level in pyloric antrum
GenevisibleiB2RXS4 MM

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 3 hits
SMARTiView protein in SMART
SM00429 IPT, 3 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 1 hit
SSF81296 SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLXB2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2RXS4
Secondary accession number(s): Q3UH76
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: July 1, 2008
Last modified: January 16, 2019
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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