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Protein
Submitted name:

Ppfia1 protein

Gene

Ppfia1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-181429 Serotonin Neurotransmitter Release Cycle
R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle
R-MMU-210500 Glutamate Neurotransmitter Release Cycle
R-MMU-212676 Dopamine Neurotransmitter Release Cycle
R-MMU-264642 Acetylcholine Neurotransmitter Release Cycle
R-MMU-388844 Receptor-type tyrosine-protein phosphatases

Names & Taxonomyi

Protein namesi
Submitted name:
Ppfia1 proteinImported
Submitted name:
Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF),-interacting protein (liprin), alpha 1Imported
Gene namesi
Name:Ppfia1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1924750 Ppfia1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000037519 Expressed in 245 organ(s), highest expression level in placenta

Interactioni

Protein-protein interaction databases

IntActiB2RXQ2, 2 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini912 – 978SAMInterPro annotationAdd BLAST67
Domaini1034 – 1091SAMInterPro annotationAdd BLAST58
Domaini1115 – 1184SAMInterPro annotationAdd BLAST70

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 60Sequence analysisAdd BLAST21
Coiled coili97 – 131Sequence analysisAdd BLAST35
Coiled coili265 – 334Sequence analysisAdd BLAST70
Coiled coili338 – 387Sequence analysisAdd BLAST50
Coiled coili412 – 467Sequence analysisAdd BLAST56
Coiled coili493 – 541Sequence analysisAdd BLAST49
Coiled coili653 – 687Sequence analysisAdd BLAST35
Coiled coili885 – 905Sequence analysisAdd BLAST21
Coiled coili1088 – 1108Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0249 Eukaryota
ENOG410XP8Z LUCA
GeneTreeiENSGT00760000119138
HOVERGENiHBG052330
OMAiEQNNQKK
OrthoDBiEOG091G14UK

Family and domain databases

CDDicd09562 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09565 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09568 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
InterProiView protein in InterPro
IPR029515 Liprin
IPR037620 Liprin-alpha_SAM_rpt_1
IPR037621 Liprin-alpha_SAM_rpt_2
IPR037622 Liprin-alpha_SAM_rpt_3
IPR030438 PPFIA1
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF15 PTHR12587:SF15, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 1 hit
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

B2RXQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMCEVMPTIS EAEGPPGGGG SHGSGSPSQP DADSHFEQLM VSMLEERDRL
60 70 80 90 100
LDTLRETQET LALTQGKLHE VGHERDSLQR QLNTALPQEF AALTKELNVC
110 120 130 140 150
REQLLEREEE IAELKAERNN TRLLLEHLEC LVSRHERSLR MTVVKRQAQS
160 170 180 190 200
PAGVSSEVEV LKALKSLFEH HKALDEKVRE RLRVALERCS LLEEELGATH
210 220 230 240 250
KELMILKEQN NQKKTLTDGL LDGNHEQESA PSTNGKRSSD GSLSHEDLAK
260 270 280 290 300
VLELQEVIDR QAREQSQMKE RLASLSSHAA ELEEDLDTAR KDLIKSEEMN
310 320 330 340 350
TKLQREVREA MAQKEDMEER ITTLEKRYLA AQREATSVHD LNDKLENEIA
360 370 380 390 400
NKDSMHRQTE DKNRQLQERL ELAEQKLQQT LRKAETLPEV EAELAQRVAA
410 420 430 440 450
LSKSGPLSSG SSAAKEAKLL ELTSKLRKAE ERHGNIEERL RQMEAQLEEK
460 470 480 490 500
NQELQRARQR EKMNEEHNKR LSDTVDKLLS ESNERLQLHL KERMAALEDK
510 520 530 540 550
NSLLREVENA KKQLEETQHD KDQLVVTIEA LKAELEQMRL RGPSLHHGRP
560 570 580 590 600
HLGSVPDFRF SVADGHVDAY STSAVLRRPQ KGRLAALRDE PSKVQTLNEQ
610 620 630 640 650
DWERAQQASV LANVAQAFES DVDVSDGEDD RDTLLSSVDL LSPSGQADAQ
660 670 680 690 700
TLAMMLQEQL DAINKEIRLI QEEKENTEQR AEEIESRVGS GSLDNLGRFR
710 720 730 740 750
SMSSIPPYPA SSLAGSSPPG SGRSTPRRVP HSPAREVDRL GVMTLPSDLR
760 770 780 790 800
KHRRQLPASR EEVRDDKTTI KCETSPPSSP RPLRLDRMHK GAPHTVSHED
810 820 830 840 850
IRDLRNSTGS QDGPVSNPSS SNSSQDSLHK APKKKGIKSS IGRLFGKKEK
860 870 880 890 900
GRPGPLGKES PGQVGVSETE NSSQDALGLS KLGGQAEKNR KLQKKHELLE
910 920 930 940 950
EARRQGLPFA QWDGPTVVVW LELWVGMPAW YVAACRANVK SGAIMSALSD
960 970 980 990 1000
TEIQREIGIS NPLHRLKLRL AIQEIMSLTS PSAPPTSRTT TGNVWLTHEE
1010 1020 1030 1040 1050
METLTATPQT EDEEGSWAQT LAYGDMNHEW IGNEWLPSLG LPQYRSYFME
1060 1070 1080 1090 1100
CLVDARMLDH LTKKDLRGQL KMVDSFHRNS FQCGIMCLRR LNYDRKELER
1110 1120 1130 1140 1150
KREESQNETR DVLVWSNDRV IRWILSIGLK EYANNLIESG VHGALLALDE
1160 1170 1180 1190 1200
TFDFSALALL LQIPTQNTQA RAVLEREFNN LLITGTDRRF DEDDDKSFRR
1210 1220 1230 1240 1250
APSWRKKFRP KDIRGLASGS AETLPANFRV TSSMSSPSMQ PKKVQMDGSV
1260
SGAQRLDSAT VRTYSC
Length:1,266
Mass (Da):142,676
Last modified:July 1, 2008 - v1
Checksum:i545C3EFBF1067EBC
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2RXW8B2RXW8_MOUSE
Ppfia1 protein
Ppfia1
1,241Annotation score:
S4R1D4S4R1D4_MOUSE
Protein tyrosine phosphatase, recep...
Ppfia1
562Annotation score:
S4R1I7S4R1I7_MOUSE
Protein tyrosine phosphatase, recep...
Ppfia1
94Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140268 Genomic DNA No translation available.
AC153792 Genomic DNA No translation available.
BC157936 mRNA Translation: AAI57937.1
BC172096 mRNA Translation: AAI72096.1
RefSeqiNP_001182015.1, NM_001195086.1
UniGeneiMm.490347

Genome annotation databases

EnsembliENSMUST00000182226; ENSMUSP00000138312; ENSMUSG00000037519
GeneIDi233977
UCSCiuc012fxz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140268 Genomic DNA No translation available.
AC153792 Genomic DNA No translation available.
BC157936 mRNA Translation: AAI57937.1
BC172096 mRNA Translation: AAI72096.1
RefSeqiNP_001182015.1, NM_001195086.1
UniGeneiMm.490347

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB2RXQ2, 2 interactors

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000182226; ENSMUSP00000138312; ENSMUSG00000037519
GeneIDi233977
UCSCiuc012fxz.1 mouse

Organism-specific databases

CTDi8500
MGIiMGI:1924750 Ppfia1

Phylogenomic databases

eggNOGiKOG0249 Eukaryota
ENOG410XP8Z LUCA
GeneTreeiENSGT00760000119138
HOVERGENiHBG052330
OMAiEQNNQKK
OrthoDBiEOG091G14UK

Enzyme and pathway databases

ReactomeiR-MMU-181429 Serotonin Neurotransmitter Release Cycle
R-MMU-181430 Norepinephrine Neurotransmitter Release Cycle
R-MMU-210500 Glutamate Neurotransmitter Release Cycle
R-MMU-212676 Dopamine Neurotransmitter Release Cycle
R-MMU-264642 Acetylcholine Neurotransmitter Release Cycle
R-MMU-388844 Receptor-type tyrosine-protein phosphatases

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037519 Expressed in 245 organ(s), highest expression level in placenta

Family and domain databases

CDDicd09562 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09565 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
cd09568 SAM_liprin-alpha1_2_3_4_repeat, 1 hit
InterProiView protein in InterPro
IPR029515 Liprin
IPR037620 Liprin-alpha_SAM_rpt_1
IPR037621 Liprin-alpha_SAM_rpt_2
IPR037622 Liprin-alpha_SAM_rpt_3
IPR030438 PPFIA1
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR12587 PTHR12587, 1 hit
PTHR12587:SF15 PTHR12587:SF15, 1 hit
PfamiView protein in Pfam
PF00536 SAM_1, 1 hit
PF07647 SAM_2, 1 hit
SMARTiView protein in SMART
SM00454 SAM, 3 hits
SUPFAMiSSF47769 SSF47769, 3 hits
PROSITEiView protein in PROSITE
PS50105 SAM_DOMAIN, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiB2RXQ2_MOUSE
AccessioniPrimary (citable) accession number: B2RXQ2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 12, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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