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Protein

Sodium/hydrogen exchanger

Gene

Slc9a5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • potassium:proton antiporter activity Source: GO_Central
  • sodium:proton antiporter activity Source: MGI

GO - Biological processi

Keywordsi

Biological processAntiportUniRule annotationSAAS annotation, Ion transport, Sodium transportUniRule annotation, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-425986 Sodium/Proton exchangers

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchangerUniRule annotation
Gene namesi
Name:Slc9a5Imported
ORF Names:mCG_23530Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2685542 Slc9a5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Transmembranei81 – 98HelicalSequence analysisAdd BLAST18
Transmembranei138 – 160HelicalSequence analysisAdd BLAST23
Transmembranei172 – 196HelicalSequence analysisAdd BLAST25
Transmembranei205 – 226HelicalSequence analysisAdd BLAST22
Transmembranei246 – 270HelicalSequence analysisAdd BLAST25
Transmembranei367 – 388HelicalSequence analysisAdd BLAST22
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Transmembranei432 – 452HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_501508716820 – 898Sodium/hydrogen exchangerSequence analysisAdd BLAST879

Expressioni

Gene expression databases

BgeeiENSMUSG00000014786 Expressed in 158 organ(s), highest expression level in cerebellum

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072893

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 458Na_H_ExchangerInterPro annotationAdd BLAST405

Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]UniRule annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1966 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00760000119074
HOGENOMiHOG000247044
HOVERGENiHBG052615
KOiK14723
OMAiPLMGHKD
OrthoDBiEOG091G02Q0
TreeFamiTF317212

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR018410 Na/H_exchanger_3/5
IPR004709 NaH_exchanger
PANTHERiPTHR10110 PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PRINTSiPR01084 NAHEXCHNGR
PR01087 NAHEXCHNGR3
TIGRFAMsiTIGR00840 b_cpa1, 1 hit

Sequencei

Sequence statusi: Complete.

B2RXE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSAALLLLP GLPLAGAGAT EEPTQESGPL GEPPPGLALF RWQWHEVEAP
60 70 80 90 100
YLVALWILVA SLAKIVFHLS RKVTSLVPES CLLILLGLVL GGIVLAVAKK
110 120 130 140 150
AEYQLEPGTF FLFLLPPIVL DSGYFMPSRL FFDNLGAILT YAVVGTLWNA
160 170 180 190 200
FTTGVALWGL QQAGLVAPRV QAGLLDFLLF GSLISAVDPV AVLAVFEEVH
210 220 230 240 250
VNQTLFIIIF GESLLNDAVT VVLYKVCNSF VEMGSANVQA TDYLKGVASL
260 270 280 290 300
FVVSLGGAAV GLVFAFLLAL TTRFTKRVRI IEPLLVFLLA YAAYLTAEMA
310 320 330 340 350
SLSAILAVTM CGLGCKKYVE ANISHKSRTA VKYTMKTLAS CAETVIFMLL
360 370 380 390 400
GISAVDSSKW AWDSGLVLGT LFFILFFRAL GVVLQTWALN QFRLVPLDKI
410 420 430 440 450
DQVVMSYGGL RGAVAFALVI LLDRTKVPAK DYFVATTIVV VFFTVIVQGL
460 470 480 490 500
TIKPLVKWLR VKRSDYHKPT LNQELHEHTF DHILAAVEDV VGHHGYHYWR
510 520 530 540 550
DRWEQFDKKY LSQLLMRRSA YRIRDQIWDV YYRLNIRDAI SFVDQGGHVL
560 570 580 590 600
SSTGLTLPSM PSRNSVAETS VTNLLRESGS GACLDLQVID TVRSGRDRED
610 620 630 640 650
AVMHHLLCGG LYKPRRRYKA SCGRHFISED AQERQDKEIF QQNMKRRLES
660 670 680 690 700
FKSTKHNICF TKSKPRPRKT SHKKKDGVAN PEATNGKPPR DLGFQDTAAV
710 720 730 740 750
ILTVESEEEE ESDSSETEKE DDEGIIFVAR ATSEVLQEGK VSGSLEVCPS
760 770 780 790 800
PRIIPPSPTC AEKELPWKSG QGDLAVYVSS ETTKIVPVDM QTGWNQSISS
810 820 830 840 850
LESLASPPCT QPPTLTRLPP HPLVTEEPQV PIDLSSDPRS SFAFPPSLAK
860 870 880 890
AGRSRSESSA DIPQQELQPL MGHKDHTHLS PGTANSHWCI QFNRGGRL
Length:898
Mass (Da):99,009
Last modified:July 1, 2008 - v1
Checksum:iAE5BBB8A4426BB42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124584 Genomic DNA No translation available.
BC151197 mRNA Translation: AAI51198.1
CH466525 Genomic DNA Translation: EDL11276.1
RefSeqiNP_001074801.1, NM_001081332.1
UniGeneiMm.334766

Genome annotation databases

EnsembliENSMUST00000073149; ENSMUSP00000072893; ENSMUSG00000014786
GeneIDi277973
KEGGimmu:277973
UCSCiuc009ncu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124584 Genomic DNA No translation available.
BC151197 mRNA Translation: AAI51198.1
CH466525 Genomic DNA Translation: EDL11276.1
RefSeqiNP_001074801.1, NM_001081332.1
UniGeneiMm.334766

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072893

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073149; ENSMUSP00000072893; ENSMUSG00000014786
GeneIDi277973
KEGGimmu:277973
UCSCiuc009ncu.1 mouse

Organism-specific databases

CTDi6553
MGIiMGI:2685542 Slc9a5

Phylogenomic databases

eggNOGiKOG1966 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00760000119074
HOGENOMiHOG000247044
HOVERGENiHBG052615
KOiK14723
OMAiPLMGHKD
OrthoDBiEOG091G02Q0
TreeFamiTF317212

Enzyme and pathway databases

ReactomeiR-MMU-425986 Sodium/Proton exchangers

Miscellaneous databases

ChiTaRSiSlc9a5 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014786 Expressed in 158 organ(s), highest expression level in cerebellum

Family and domain databases

InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR018410 Na/H_exchanger_3/5
IPR004709 NaH_exchanger
PANTHERiPTHR10110 PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999 Na_H_Exchanger, 1 hit
PRINTSiPR01084 NAHEXCHNGR
PR01087 NAHEXCHNGR3
TIGRFAMsiTIGR00840 b_cpa1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB2RXE2_MOUSE
AccessioniPrimary (citable) accession number: B2RXE2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 12, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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