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Protein
Submitted name:

3222402P14Rik protein

Gene

Ppp2r3a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi984 – 995PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • protein binding, bridging Source: MGI
  • protein phosphatase regulator activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
3222402P14Rik proteinImported
Submitted name:
MCG15724, isoform CRA_bImported
Submitted name:
Protein phosphatase 2, regulatory subunit B'', alphaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ppp2r3aImported
Synonyms:3222402P14RikImported
ORF Names:mCG_15724Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2442104 Ppp2r3a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000043154 Expressed in 238 organ(s), highest expression level in quadriceps femoris

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000075327

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini765 – 792EF-handInterPro annotationAdd BLAST28
Domaini971 – 1006EF-handInterPro annotationAdd BLAST36

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2562 Eukaryota
ENOG410XRBK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154659

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013216

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000013

KEGG Orthology (KO)

More...
KOi
K11583

Database of Orthologous Groups

More...
OrthoDBi
255081at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105554

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499 EF-hand_7, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B2RXC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATYRLVVS TVNHYSSVVI DRRFEQAIHY CTGTCHTFTH GIDCIVVHHS
60 70 80 90 100
VCADLVHIPV SQFKDVDLNS VFLSHENGLS SAEDYPHQAL TGLPRGKKAS
110 120 130 140 150
TFQNTCNLKD IAGEAISFAS GKIKEFSLEK LRNSNHAAYR KGRKVKSDSF
160 170 180 190 200
NRRSVDFDLL CGHYNNDGTS PPFGLLRSSS VEEKSLSHRN SLDTNLTSML
210 220 230 240 250
FQNLSEEDLV TQILEKHKID HFSSGTDIKM CLDILLKCSE DLKKCTDIIK
260 270 280 290 300
QCIKKKSGGS ISEGSGNEVI SNSETVYMNV MTRLAYYLRK LPFEFMQSGN
310 320 330 340 350
NETVDLTELI NNIPNLQLTP FSPLYGTEQP PKYEDIVHLS ALDSGQFQTV
360 370 380 390 400
ELQDDKHNFK QTDIVKTTPN NTDSLCSLEV NDPGTLKPVQ LQSPLLTINH
410 420 430 440 450
LENVSSGNLM ETLYIEEESD GKKSLLDKEQ KAENGQGQEP LQVNEHKEFS
460 470 480 490 500
DHDTYLKKCP VSMQNEIGKI FEKPIMVHPS KEDSKLEVPT TDLRDQRHFV
510 520 530 540 550
NPNSQEEIDK LLMDLESFSQ KMETSLGEPL AKGKSINSLN SHSHLTAQSH
560 570 580 590 600
KDLEPKPIAS SAMEKVSPSC LTRIIENNGH KMEEEDRALL LRIMESIEDF
610 620 630 640 650
AQELVECKSG RGSLSQEKEM MQILQETLTT SSQPTPSVCR SPVGEKPKDS
660 670 680 690 700
TSVVLIQQTP EVIKIQNKPE KKPATSFPPA ATLPSSPQPA SPVPCVSDVV
710 720 730 740 750
NTPLSINIPQ FYFPEGLPDT CSNHEQILSR IETAFKDIED QKADIHEMGR
760 770 780 790 800
IAKVCGCPLY WKAPMFRAAG GEKTGFVTAQ SFIAMWKKLL SNRHDDAAKF
810 820 830 840 850
IWLLAKPSCS YLEQEDFIPL LQDVVDTHPG LTFLKDAPEF HSRYITTVVQ
860 870 880 890 900
RIFYTVNRSW SGKITSTEIR KSNFLQTLAL LEEEEDINQI TDYFSYEHFY
910 920 930 940 950
VIYCKFWELD GDHDLYISQA DLSRYNDQAS SNRIIERIFS GAVTRGKTVQ
960 970 980 990 1000
KEGRMSYADF VWFLISEEDK RNPTSIEYWF RCMDVDGDGI LSMYELEYFY
1010 1020 1030 1040 1050
EEQCERMEAM GIEPLPFHDL LCQMLDLVKP ASDGRITLRD LKRCRMAHIF
1060 1070 1080 1090 1100
YDTFFNLEKY LDHEQRDPFA VQKDVENDGP EPSDWDRFAA EEYEALVTEE
1110 1120 1130 1140 1150
SAQVQLQEGS FEDYESDEPV SPSELGNKGN KIVTSSLSEK CGKLQSVDEE
Length:1,150
Mass (Da):130,257
Last modified:July 1, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44BCE5CE2B4330BF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X9E8G3X9E8_MOUSE
MCG15724, isoform CRA_a
Ppp2r3a mCG_15724
530Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC120390 Genomic DNA No translation available.
AC138288 Genomic DNA No translation available.
AC242670 Genomic DNA No translation available.
BC151170 mRNA Translation: AAI51171.1
BC151171 mRNA Translation: AAI51172.1
CH466560 Genomic DNA Translation: EDL21039.1

NCBI Reference Sequences

More...
RefSeqi
NP_001154834.1, NM_001161362.3
XP_017168836.1, XM_017313347.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.335386

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000075941; ENSMUSP00000075327; ENSMUSG00000043154

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
235542

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:235542

UCSC genome browser

More...
UCSCi
uc009rfh.3 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC120390 Genomic DNA No translation available.
AC138288 Genomic DNA No translation available.
AC242670 Genomic DNA No translation available.
BC151170 mRNA Translation: AAI51171.1
BC151171 mRNA Translation: AAI51172.1
CH466560 Genomic DNA Translation: EDL21039.1
RefSeqiNP_001154834.1, NM_001161362.3
XP_017168836.1, XM_017313347.1
UniGeneiMm.335386

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075327

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
235542
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075941; ENSMUSP00000075327; ENSMUSG00000043154
GeneIDi235542
KEGGimmu:235542
UCSCiuc009rfh.3 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5523
MGIiMGI:2442104 Ppp2r3a

Phylogenomic databases

eggNOGiKOG2562 Eukaryota
ENOG410XRBK LUCA
GeneTreeiENSGT00940000154659
HOGENOMiHOG000013216
HOVERGENiHBG000013
KOiK11583
OrthoDBi255081at2759
TreeFamiTF105554

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ppp2r3a mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000043154 Expressed in 238 organ(s), highest expression level in quadriceps femoris

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2RXC8_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2RXC8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: January 16, 2019
This is version 86 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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