UniProtKB - B2RXC5 (ZN382_MOUSE)
Protein
Zinc finger protein 382
Gene
Znf382
Organism
Mus musculus (Mouse)
Status
Functioni
Functions as a sequence-specific transcriptional repressor.By similarity
Caution
It is uncertain whether Met-1 or Met-37 is the initiator.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 241 – 263 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 325 – 347 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 353 – 375 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 381 – 403 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 409 – 431 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 437 – 459 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 465 – 487 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 493 – 515 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 521 – 543 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 549 – 571 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: MGI
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 382Alternative name(s): KRAB/zinc finger suppressor protein 1 Short name: KS1 Multiple zinc finger and krueppel-associated box protein KS1 |
Gene namesi | Name:Znf382 Synonyms:Zfp382 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3588204, Zfp382 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nuclear chromatin Source: GO_Central
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000361567 | 1 – 579 | Zinc finger protein 382Add BLAST | 579 |
Proteomic databases
MaxQBi | B2RXC5 |
PaxDbi | B2RXC5 |
PRIDEi | B2RXC5 |
PTM databases
PhosphoSitePlusi | B2RXC5 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000074220, Expressed in spermatocyte and 54 other tissues |
Interactioni
Subunit structurei
Interacts with TRIM28; enhances the transcriptional repressor activity.
1 PublicationProtein-protein interaction databases
BioGRIDi | 231361, 27 interactors |
STRINGi | 10090.ENSMUSP00000096196 |
Miscellaneous databases
RNActi | B2RXC5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 42 – 113 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 12 – 135 | Mediates interaction with TRIM28By similarityAdd BLAST | 124 | |
Regioni | 40 – 81 | Represses transcriptionBy similarityAdd BLAST | 42 | |
Regioni | 105 – 240 | Represses transcriptionBy similarityAdd BLAST | 136 | |
Regioni | 325 – 579 | Required for transcriptional repression activity; probably mediates sequence-specific DNA-bindingBy similarityAdd BLAST | 255 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 241 – 263 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 325 – 347 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 353 – 375 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 381 – 403 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 409 – 431 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 437 – 459 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 465 – 487 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 493 – 515 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 521 – 543 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 549 – 571 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162338 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | B2RXC5 |
OMAi | SFEHNEC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | B2RXC5 |
TreeFami | TF337898 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
B2RXC5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRPGRKPRG RARPGLFPFP KEELRQGGSS PANLNAMSKG PVSFKDVTVD
60 70 80 90 100
FTQEEWQRLD PAQKALYRDV MLENYCHFIS VGFHITKPDM IRKLEQGEEL
110 120 130 140 150
WTERIFPSQS YLEEEEVLVK FSDYQDKPPK SIVIIKHKKL IKERSSVYGE
160 170 180 190 200
ALGKNRVVSK TLFEYKSDGK VLKNISEFIS RDINPAMGKL GGSKEWEGSI
210 220 230 240 250
LTSKQEKTHP ASILHKQIGR ALSSEWDLAQ HQKTQIPEQR FEYNKCDSSF
260 270 280 290 300
LMTGVEFPHG RAHRGGGNFN YSKDDITLFE KSDLGIHPHD LMEKKCSSYN
310 320 330 340 350
KYGELLCRKS VFVMHPSSQM DERPFQCPYC GNSFRRKSYL IEHERIHTGE
360 370 380 390 400
KPYICCQCGR AFRQKTALTL HEKTHTEGKP YLCVDCGKSF RQKATLTRHH
410 420 430 440 450
KAHTGEKAYE CTQCGSAFGK KSYLIDHQRT HTGEKPYQCT ECGKAFIQKT
460 470 480 490 500
TLTVHQRTHT GEKPYICSEC GKSFCQKTTL TLHQRIHTGE KPYICSDCGK
510 520 530 540 550
SFRQKAILTV HYRIHTGEKS NGCPQCGKAF SRKSNLIRHQ KIHTGEKPYE
560 570
CQECGKFFSC KSNLITHQKT HKTETMRFQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3YYS3 | D3YYS3_MOUSE | Zinc finger protein 382 | Zfp382 | 87 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 576 | M → T in BAE22072 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH466593 Genomic DNA Translation: EDL24044.1 BC151163 mRNA Translation: AAI51164.1 AK134263 mRNA Translation: BAE22072.1 |
CCDSi | CCDS39877.1 |
RefSeqi | NP_001074476.1, NM_001081007.1 |
Genome annotation databases
Ensembli | ENSMUST00000098596; ENSMUSP00000096196; ENSMUSG00000074220 |
GeneIDi | 233060 |
KEGGi | mmu:233060 |
UCSCi | uc009gdf.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH466593 Genomic DNA Translation: EDL24044.1 BC151163 mRNA Translation: AAI51164.1 AK134263 mRNA Translation: BAE22072.1 |
CCDSi | CCDS39877.1 |
RefSeqi | NP_001074476.1, NM_001081007.1 |
3D structure databases
SMRi | B2RXC5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 231361, 27 interactors |
STRINGi | 10090.ENSMUSP00000096196 |
PTM databases
PhosphoSitePlusi | B2RXC5 |
Proteomic databases
MaxQBi | B2RXC5 |
PaxDbi | B2RXC5 |
PRIDEi | B2RXC5 |
Protocols and materials databases
Antibodypediai | 16319, 29 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000098596; ENSMUSP00000096196; ENSMUSG00000074220 |
GeneIDi | 233060 |
KEGGi | mmu:233060 |
UCSCi | uc009gdf.1, mouse |
Organism-specific databases
CTDi | 233060 |
MGIi | MGI:3588204, Zfp382 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162338 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | B2RXC5 |
OMAi | SFEHNEC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | B2RXC5 |
TreeFami | TF337898 |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 233060, 1 hit in 17 CRISPR screens |
PROi | PR:B2RXC5 |
RNActi | B2RXC5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000074220, Expressed in spermatocyte and 54 other tissues |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 9 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN382_MOUSE | |
Accessioni | B2RXC5Primary (citable) accession number: B2RXC5 Secondary accession number(s): Q3UYY9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 20, 2009 |
Last sequence update: | July 1, 2008 | |
Last modified: | December 2, 2020 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families