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Protein

Kinase

Gene

Itpkb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei686ATPCombined sources1
Binding sitei893ATPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi669 – 670ATPCombined sources2
Nucleotide bindingi726 – 728ATPCombined sources3
Nucleotide bindingi739 – 741ATPCombined sources3

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • inositol-1,4,5-trisphosphate 3-kinase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
LigandATP-bindingCombined sources, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.127 3474
ReactomeiR-MMU-1855204 Synthesis of IP3 and IP4 in the cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
KinaseUniRule annotation (EC:2.7.-.-UniRule annotation)
Gene namesi
Name:ItpkbImported
ORF Names:mCG_6217Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:109235 Itpkb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3714704

Expressioni

Gene expression databases

BgeeiENSMUSG00000038855 Expressed in 256 organ(s), highest expression level in urinary bladder

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069851

Structurei

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the inositol phosphokinase (IPK) family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1621 Eukaryota
ENOG410Y8AC LUCA
GeneTreeiENSGT00390000017438
HOGENOMiHOG000060305
HOVERGENiHBG052139
KOiK00911
OMAiEPLPCWE
OrthoDBiEOG091G03J3
TreeFamiTF318394

Family and domain databases

Gene3Di1.10.510.50, 1 hit
InterProiView protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf
PANTHERiPTHR12400 PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770 IPK, 1 hit

Sequencei

Sequence statusi: Complete.

B2RXC2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVYCYALNS LVIMNSTNEL KSGGPRPSGS ETPQPSGRAA LSPGSVFSPG
60 70 80 90 100
RGASFLFPPA ESLSLEEPGS PGGWRSGRRR LNSSSGSGGG SSSSNSSSSS
110 120 130 140 150
GVGSPSWAGR LRGDAQQVVA ARILSPPGPE EAQRKLRILQ RELQNVQVNQ
160 170 180 190 200
KVGMFEAQIQ AQSSAIQAPR SPRLGRARSP SPCPFRSSSQ PPERVLAPCS
210 220 230 240 250
PSEERRTKSW GEQCTETPDT NSGRRSRLST HPSKDKEGVA PLLGPASPTR
260 270 280 290 300
LGTQSPSTSV RMERGTPASP RCGSPTPMET DKRVAPSLER FGTSLTLATK
310 320 330 340 350
VAASAASAGP HPGHDSALME TGCELGGMRP WEAQMERRGQ FLGKETGSTP
360 370 380 390 400
EPVRTHMREP PGRVGRGIHS VGGQGSWTPE VIKRPEERAV TAQSSEPSED
410 420 430 440 450
PRWSRLPVDL DSVGPEKGGN RIPGMRGPQQ TLDSEREGSP ALGLLGGSQA
460 470 480 490 500
AQPGARGVEE DVHYGRMLEP LPPGEVTTKL KEPQCLPGDR MGMQPESSIV
510 520 530 540 550
WPSALEEAPL IWTRDTGVQS KGTWGSQLPD GDAHPSCQEM PPDQKDKASL
560 570 580 590 600
KEACSPSNIP AIPAVIITDM GAQEDGGLEE IQGSPRGPLP LRKLSSSSAS
610 620 630 640 650
STGFSSSYDD SEEDISSDPE RTLDPNSAFL HTLDQQKPRV SKSWRKIKNM
660 670 680 690 700
VQWSPFVMSF KKKYPWIQLA GHAGSFKAAA NGRILKKHCE SEQRCLDRLM
710 720 730 740 750
ADVLRPFVPA YHGDVVKDGE RYNQMDDLLA DFDSPCVMDC KMGVRTYLEE
760 770 780 790 800
ELTKARKKPS LRKDMYQKMV EVDPEAPTEE EKAQRAVTKP RYMQWRETIS
810 820 830 840 850
STATLGFRIE GIKKEDGSVN RDFKKTKTRE QVTEAFREFT KGNQNILIAY
860 870 880 890 900
RDRLKAIRAT LEISPFFKCH EVIGSSLLFI HDKKEQAKVW MIDFGKTTPL
910 920 930 940
PEGQTLQHDV PWQEGNREDG YLSGLDNLID ILTEMSQGSP LT
Length:942
Mass (Da):102,673
Last modified:July 1, 2008 - v1
Checksum:iDABAEE912F737114
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121838 Genomic DNA No translation available.
BC151160 mRNA Translation: AAI51161.1
BC157986 mRNA Translation: AAI57987.1
BC158000 mRNA Translation: AAI58001.1
CH466555 Genomic DNA Translation: EDL13155.1
RefSeqiNP_001074644.1, NM_001081175.1
UniGeneiMm.132535
Mm.383297

Genome annotation databases

EnsembliENSMUST00000070181; ENSMUSP00000069851; ENSMUSG00000038855
GeneIDi320404
KEGGimmu:320404
UCSCiuc007dwg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121838 Genomic DNA No translation available.
BC151160 mRNA Translation: AAI51161.1
BC157986 mRNA Translation: AAI57987.1
BC158000 mRNA Translation: AAI58001.1
CH466555 Genomic DNA Translation: EDL13155.1
RefSeqiNP_001074644.1, NM_001081175.1
UniGeneiMm.132535
Mm.383297

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2AQXX-ray2.50A/B650-938[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069851

Chemistry databases

ChEMBLiCHEMBL3714704

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070181; ENSMUSP00000069851; ENSMUSG00000038855
GeneIDi320404
KEGGimmu:320404
UCSCiuc007dwg.1 mouse

Organism-specific databases

CTDi3707
MGIiMGI:109235 Itpkb

Phylogenomic databases

eggNOGiKOG1621 Eukaryota
ENOG410Y8AC LUCA
GeneTreeiENSGT00390000017438
HOGENOMiHOG000060305
HOVERGENiHBG052139
KOiK00911
OMAiEPLPCWE
OrthoDBiEOG091G03J3
TreeFamiTF318394

Enzyme and pathway databases

BRENDAi2.7.1.127 3474
ReactomeiR-MMU-1855204 Synthesis of IP3 and IP4 in the cytosol

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038855 Expressed in 256 organ(s), highest expression level in urinary bladder

Family and domain databases

Gene3Di1.10.510.50, 1 hit
InterProiView protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf
PANTHERiPTHR12400 PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770 IPK, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB2RXC2_MOUSE
AccessioniPrimary (citable) accession number: B2RXC2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 7, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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