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Protein
Submitted name:

Gamma-aminobutyric acid (GABA) receptor, rho 3

Gene

Gabrr3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotation, ReceptorImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-977442 GABA A (rho) receptor activation

Names & Taxonomyi

Protein namesi
Submitted name:
Gamma-aminobutyric acid (GABA) receptor, rho 3Imported
Submitted name:
MCG129069Imported
Gene namesi
Name:Gabrr3Imported
ORF Names:mCG_129069Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:3588203 Gabrr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei264 – 287HelicalSequence analysisAdd BLAST24
Transmembranei299 – 318HelicalSequence analysisAdd BLAST20
Transmembranei330 – 352HelicalSequence analysisAdd BLAST23
Transmembranei446 – 463HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501508716519 – 464Sequence analysisAdd BLAST446

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000074991 Expressed in 23 organ(s), highest expression level in Ammon's horn

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109980

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 263Neur_chan_LBDInterPro annotationAdd BLAST200
Domaini271 – 353Neur_chan_membInterPro annotationAdd BLAST83

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00760000118821
HOGENOMiHOG000231335
HOVERGENiHBG051707
KOiK05190
OMAiHDTTVEN
OrthoDBiEOG091G0805
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

B2RXA8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLAVWLVSF TYTWITLMLD ASAIKKPHQQ CLSSPKQTRI RETRMRKDDL
60 70 80 90 100
TKVWHPKREQ LLHIEDHDFS TRPGFGGSPV PVGIDVQVES IDSISEVNMD
110 120 130 140 150
FTMTFYLRHY WKDERLSFPS TTNKSMTFDR RLLQKIWVPD IFFVHSKRSF
160 170 180 190 200
IHDTTVENIM LRVHPDGNVL FSLRITVSAM CFMDFSRFPL DTQNCSLELE
210 220 230 240 250
SYAYNEEDLM LYWKHGNKSL NTEERISLSQ FFIEEFSASS GLAFYSSTGW
260 270 280 290 300
YYRLFINFVL RRHVFFFVLQ TYFPAMLMVM LSWVSFWIDR RAVPARVSLG
310 320 330 340 350
ITTVLTMSTV VTGVSASMPQ VSYVKAVDVY MWVSSLFVFL SVIEYATVNY
360 370 380 390 400
LTTVEEWKQL NRRGKISGMY HIDAVQAMAF DGCYHDSETD VDQTSFSLHS
410 420 430 440 450
EEDSMSTKFT GSPCADSSQI KRKSLGGNVG RIILENNHVI DTYSRIVFPT
460
VYIIFNLFYW GIYV
Length:464
Mass (Da):53,935
Last modified:July 1, 2008 - v1
Checksum:iF331D596A4A05952
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154854 Genomic DNA No translation available.
BC151105 mRNA Translation: AAI51106.1
CH466521 Genomic DNA Translation: EDK98223.1
RefSeqiNP_001074659.1, NM_001081190.1
UniGeneiMm.451970

Genome annotation databases

EnsembliENSMUST00000114341; ENSMUSP00000109980; ENSMUSG00000074991
GeneIDi328699
KEGGimmu:328699
UCSCiuc007zpf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC154854 Genomic DNA No translation available.
BC151105 mRNA Translation: AAI51106.1
CH466521 Genomic DNA Translation: EDK98223.1
RefSeqiNP_001074659.1, NM_001081190.1
UniGeneiMm.451970

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109980

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114341; ENSMUSP00000109980; ENSMUSG00000074991
GeneIDi328699
KEGGimmu:328699
UCSCiuc007zpf.1 mouse

Organism-specific databases

CTDi200959
MGIiMGI:3588203 Gabrr3

Phylogenomic databases

eggNOGiKOG3643 Eukaryota
ENOG410XPWH LUCA
GeneTreeiENSGT00760000118821
HOGENOMiHOG000231335
HOVERGENiHBG051707
KOiK05190
OMAiHDTTVEN
OrthoDBiEOG091G0805
TreeFamiTF315453

Enzyme and pathway databases

ReactomeiR-MMU-977442 GABA A (rho) receptor activation

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074991 Expressed in 23 organ(s), highest expression level in Ammon's horn

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB2RXA8_MOUSE
AccessioniPrimary (citable) accession number: B2RXA8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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