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Protein
Submitted name:

Cholinergic receptor, nicotinic, alpha polypeptide 10

Gene

Chrna10

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • acetylcholine-gated cation-selective channel activity Source: MGI
  • transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Cholinergic receptor, nicotinic, alpha polypeptide 10Imported
Submitted name:
MCG6769, isoform CRA_aImported
Gene namesi
Name:Chrna10Imported
ORF Names:mCG_6769Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3609260 Chrna10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei236 – 258HelicalSequence analysisAdd BLAST23
Transmembranei270 – 289HelicalSequence analysisAdd BLAST20
Transmembranei301 – 320HelicalSequence analysisAdd BLAST20
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_501508716025 – 447Sequence analysisAdd BLAST423

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000066279 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Interactioni

Protein-protein interaction databases

ComplexPortaliCPX-223 Neuronal nicotinic acetylcholine receptor complex, alpha9-alpha10

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 235Neur_chan_LBDInterPro annotationAdd BLAST205
Domaini243 – 357Neur_chan_membInterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
HOGENOMiHOG000006756
HOVERGENiHBG003756
KOiK04811
OMAiCHEDWKR
OrthoDBiEOG091G0R20
TreeFamiTF315605

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

B2RX82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTRSHHLGP GFLLLLFLPA ECLGAEGRLA HKLFRDLFAN YTSALRPVAD
60 70 80 90 100
TDQTLNVTLE VTLSQIIDMD ERNQVLTLYL WIRQEWTDAY LHWDPKAYGD
110 120 130 140 150
LDAIRIPSSL VWRPDIVLYN KADTQPPASA STNVVVRHDG AVRWDAPAIT
160 170 180 190 200
RSSCRVDVSA FPFDAQRCGL TFGSWTHGGH QLDVRPRGTS ASLADFVENV
210 220 230 240 250
EWRVLGMPAR RRVLTYGCCS EPYPDVTFTL LLRRRAAAYV CNLLLPCVFI
260 270 280 290 300
SLLAPLAFHL PADSGEKVSL GVTVLLALTV FQLILAESMP PAESVPLIGK
310 320 330 340 350
YYMATMTMVT FSTALTILIM NLHYCGPNAH PVPAWARVLL LGHLAKGLCV
360 370 380 390 400
RERGEPCGQS KPLESAPSLQ PPAGPPAGPC HEPRCLCHQE ALLHHVASIA
410 420 430 440
GTFRSHRAAQ RRHEDWKRLA RVMDRFFLGI FFCMALVMSL LVLVQAL
Length:447
Mass (Da):49,577
Last modified:July 1, 2008 - v1
Checksum:i24B39F5EDD679C3E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GRL8A0A1B0GRL8_MOUSE
Cholinergic receptor, nicotinic, al...
Chrna10
47Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118592 Genomic DNA No translation available.
AC132297 Genomic DNA No translation available.
BC147245 mRNA Translation: AAI47246.1
BC147246 mRNA Translation: AAI47247.1
BC151033 mRNA Translation: AAI51034.1
BC151035 mRNA Translation: AAI51036.1
CH466531 Genomic DNA Translation: EDL16580.1
CH466531 Genomic DNA Translation: EDL16581.1
RefSeqiNP_001074893.1, NM_001081424.1
XP_006508071.1, XM_006508008.3
XP_006508072.1, XM_006508009.2
UniGeneiMm.334074

Genome annotation databases

EnsembliENSMUST00000084830; ENSMUSP00000081891; ENSMUSG00000066279
GeneIDi504186
KEGGimmu:504186
UCSCiuc009iqw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118592 Genomic DNA No translation available.
AC132297 Genomic DNA No translation available.
BC147245 mRNA Translation: AAI47246.1
BC147246 mRNA Translation: AAI47247.1
BC151033 mRNA Translation: AAI51034.1
BC151035 mRNA Translation: AAI51036.1
CH466531 Genomic DNA Translation: EDL16580.1
CH466531 Genomic DNA Translation: EDL16581.1
RefSeqiNP_001074893.1, NM_001081424.1
XP_006508071.1, XM_006508008.3
XP_006508072.1, XM_006508009.2
UniGeneiMm.334074

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-223 Neuronal nicotinic acetylcholine receptor complex, alpha9-alpha10

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084830; ENSMUSP00000081891; ENSMUSG00000066279
GeneIDi504186
KEGGimmu:504186
UCSCiuc009iqw.1 mouse

Organism-specific databases

CTDi57053
MGIiMGI:3609260 Chrna10

Phylogenomic databases

eggNOGiKOG3645 Eukaryota
ENOG410XQGR LUCA
GeneTreeiENSGT00910000144023
HOGENOMiHOG000006756
HOVERGENiHBG003756
KOiK04811
OMAiCHEDWKR
OrthoDBiEOG091G0R20
TreeFamiTF315605

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066279 Expressed in 10 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB2RX82_MOUSE
AccessioniPrimary (citable) accession number: B2RX82
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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