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UniProtKB - B2RX14 (TUT4_MOUSE)

Entry version 91 (16 Oct 2019)
Sequence version 2 (22 Sep 2009)
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Protein

Terminal uridylyltransferase 4

Gene

Tut4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:28792939). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (PubMed:28792939). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (By similarity). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7), miR107, miR-143 and miR-200c. Uridylated miRNAs are not processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cell pluripotency (By similarity). Also catalyzes the 3' uridylation of miR-26A, a miRNA that targets IL6 transcript. This abrogates the silencing of IL6 transcript, hence promoting cytokine expression (PubMed:19703396). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (PubMed:28671666). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (By similarity). May also suppress Toll-like receptor-induced NF-kappa-B activation via binding to T2BP (By similarity). Does not play a role in replication-dependent histone mRNA degradation (By similarity). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:28671666, PubMed:28792939, PubMed:22898984). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (By similarity).By similarity4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi326Zinc 1By similarity1
Metal bindingi329Zinc 1By similarity1
Metal bindingi342Zinc 1By similarity1
Metal bindingi348Zinc 1By similarity1
Metal bindingi1026Magnesium or manganese; catalyticBy similarity1
Metal bindingi1028Magnesium or manganese; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1098UTPBy similarity1
Binding sitei1120UTPBy similarity1
Binding sitei1254UTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri324 – 354Matrin-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri930 – 947CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri1310 – 1327CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri1358 – 1375CCHC-type 3PROSITE-ProRule annotationAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processRNA-mediated gene silencing
LigandMagnesium, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-429947 Deadenylation of mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Terminal uridylyltransferase 4Curated (EC:2.7.7.521 Publication)
Short name:
TUTase 4
Alternative name(s):
Zinc finger CCHC domain-containing protein 11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tut4Imported
Synonyms:Kiaa0191, Zcchc11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2445126 Tut4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Double conditional knockouts that have deleted both TUT4 and TUT7 at the secondary oocyte stage are infertile. Females ovulate normal numbers of oocytes with normal morphology of antral follicles but with a slight decrease in the frequency of surrounded nucleolus state oocytes. Mutant oocytes are unable to support early embryonic development, they fail to complete meiosis I properly.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi326C → A: No effect on basal uridylation activity, but loss of LIN28A-enhanced uridylation; when associated with A-329. 1 Publication1
Mutagenesisi329C → A: No effect on basal uridylation activity, but loss of LIN28A-enhanced uridylation; when associated with A-326. 1 Publication1
Mutagenesisi1026D → A: Loss of nucleotidyltransferase activity and oocytes are unable to support early embryonic development; when associated with A-1028. 2 Publications1
Mutagenesisi1028D → A: Loss of nucleotidyltransferase activity and oocytes are unable to support early embryonic development; when associated with A-1026. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003853301 – 1644Terminal uridylyltransferase 4Add BLAST1644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei102PhosphoserineBy similarity1
Modified residuei131PhosphoserineCombined sources1
Modified residuei176PhosphoserineCombined sources1
Modified residuei1624Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		B2RX14

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		B2RX14

MaxQB - The MaxQuant DataBase

More...MaxQBi		B2RX14

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		B2RX14

PRoteomics IDEntifications database

More...PRIDEi		B2RX14

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		B2RX14

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		B2RX14

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000034610 Expressed in 240 organ(s), highest expression level in dorsal pancreas

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		B2RX14 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		B2RX14 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LIN28A in the presence of pre-let-7 RNA (PubMed:28671666).

Interacts with T2BP.

Interacts with MOV10; the interaction is RNA-dependent.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		230978, 1 interactor

Database of interacting proteins

More...DIPi		DIP-48571N

Protein interaction database and analysis system

More...IntActi		B2RX14, 1 interactor

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000095538

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		B2RX14

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini649 – 698PAP-associated 1Add BLAST50
Domaini1201 – 1254PAP-associated 2Add BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni273 – 353Required for interaction with LIN28A and pre-let-7 RNABy similarityAdd BLAST81
Regioni918 – 1634Sufficient for monouridylation activityBy similarityAdd BLAST717
Regioni1015 – 1018UTP bindingBy similarity4
Regioni1025 – 1028UTP bindingBy similarity4
Regioni1138 – 1142UTP bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1425 – 1598Pro-richAdd BLAST174

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Utilizes two multidomain functional modules during the switch from monouridylation to oligouridylation. The catalytic module (containing the 3 CCHC-type Zinc finger domains) is essential for both activites while the Lin28-interacting module (LIM) at the N-termail part is indispensable for oligouridylation.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B-like family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri324 – 354Matrin-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri930 – 947CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri1310 – 1327CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri1358 – 1375CCHC-type 3PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2277 Eukaryota
COG5260 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156988

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231134

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		B2RX14

KEGG Orthology (KO)

More...KOi		K13291

Identification of Orthologs from Complete Genome Data

More...OMAi		NWIEGFD

Database of Orthologous Groups

More...OrthoDBi		803033at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002058 PAP_assoc
IPR002934 Polymerase_NTP_transf_dom
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01909 NTP_transf_2, 1 hit
PF03828 PAP_assoc, 2 hits
PF00098 zf-CCHC, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00343 ZnF_C2HC, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57756 SSF57756, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50158 ZF_CCHC, 3 hits
PS00028 ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

B2RX14-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEPKTSKNE NHEPKKNIIC EESKAVKIIS NQTLKPRNDK SEIGTSSLNR 
        60         70         80         90        100
NSSKKTKQND ICIEKTEAKS CKVNAASVPG PKDLGLVHRD QSHCKMKKLP 
       110        120        130        140        150
NSPMKAQKGS SQTKLEKTPS LQTKAEKVPK SPNLPVKAEK APCTTAEATT 
       160        170        180        190        200
EKALNSQRKE ENTPTSQMKL QKTPRSPLEP ENVPSLLLKE NVKQTESQQT 
       210        220        230        240        250
GKKLTSSFVS MDKRKSEALQ GEKSALENSS LSQKQQTQTD NIADSDDSAS 
       260        270        280        290        300
GIEDTADDLS KMKSEESNKE NSSEMDYLEN ATVIDESALT PEQRLGLKQA 
       310        320        330        340        350
EERLERDHIF RLEKRSPEYT NCRYLCKLCL IHIENIQGAH KHIKEKRHKK 
       360        370        380        390        400
NILEKQEESE LRSLPSPSSA HLAALSVAVV ELAKEQGITD DDLRIRQDIV 
       410        420        430        440        450
EEMSKVIMTF LPECSLRLYG SSLTKFALKS SDVNIDIKFP PKMNHPDLLI 
       460        470        480        490        500
QVLGILKKSA LYIDVESDFH AKVPVVVCKD RKSALLCRVS AGNDMACLTT 
       510        520        530        540        550
DLLAALGKVE PVFTPLVLAF RYWAKLCYID SQTDGGIPSY CFALMVMFFL 
       560        570        580        590        600
QQRKPPLLPC LLGSWIEGFD PKRMDDFQLK GIVEEKFVKW EYNSSSATEK 
       610        620        630        640        650
NLIADENKAK ADEPKDDTKK TETDNQSNAA KAKHGKSPLT LEAPNQVPLG 
       660        670        680        690        700
QLWLELLKFY TLDFALEEYV ICVRIQDILT RENKNWPKRR IAIEDPFSVK 
       710        720        730        740        750
RNVARSLNSQ LVYEYVVERF RAAYRYFACP QKKGGNKSTM DPKKKEKGKL 
       760        770        780        790        800
SSKKPVKSDC SATNCCILGE SAEKIHMERG QPAKHDETEF TSQRCIVDND 
       810        820        830        840        850
SLLVNELGLA NHGQDSSSLS TASGGSDLKQ KSAEKQGDLT PSETSLKKEL 
       860        870        880        890        900
SQCICIGTPD GAESAGTDCR SNLEMDSSHQ IVCNNVSATS CNCKATEVTS 
       910        920        930        940        950
DLVDEDNLPS QELYYVFDKF ILTSGKPPTI VCSICKKDGH SKNDCPEDFR 
       960        970        980        990       1000
KIDLKPLPPM TNRFREILDL VCKRCFDELS PPCSEQHNRE QILIGLEKFI 
      1010       1020       1030       1040       1050
QKEYDEKARL CLFGSSKNGF GFRDSDLDIC MTLEGHENAE KLNCKEIIEN 
      1060       1070       1080       1090       1100
LAKILKRHPG LRNILPITTA KVPIVKFEHR RSGLEGDISL YNTLAQHNTR 
      1110       1120       1130       1140       1150
MLATYAAIDP RVQYLGYTMK VFAKRCDIGD ASRGSLSSYA YILMVLYFLQ 
      1160       1170       1180       1190       1200
QRKPPVIPVL QEIFDGKQIP QRMVDGWNAF FFDKTEELKK RLPSLGKNTE 
      1210       1220       1230       1240       1250
SLGELWLGLL RFYTEEFDFK EYVISIRQKK LLTTFEKQWT SKCIAIEDPF 
      1260       1270       1280       1290       1300
DLNHNLGAGV SRKMTNFIMK AFINGRKLFG TPFYPLIGRE AEYFFDSRVL 
      1310       1320       1330       1340       1350
TDGELAPNDR CCRVCGKIGH YMKDCPKRKR LKKKDSEEEK EGNEEEKDSR 
      1360       1370       1380       1390       1400
DLLDSRDLRC FICGDAGHVR RECPEVKMAR QRNSSVAAAQ LVRNLVNAQQ 
      1410       1420       1430       1440       1450
VAGSAQQQSD QSIRTRQSSE CSDSPSYSPQ PQPFPQNSPQ PSALPPPPSQ 
      1460       1470       1480       1490       1500
PGSQPKLGPP QQGGQPPHQV QMPLYNFPQS PPAHYSPMHS MGLLPMHPLQ 
      1510       1520       1530       1540       1550
IPAPSWPIHG PMLHSAPGST PSNIGLNDPS IIFAQPAARP MAIPSPSHDG 
      1560       1570       1580       1590       1600
HWPRTVAPNS LVNNGAVGNS EPRFRGLNPP IPWEHAPRHF PLVPASWPYG 
      1610       1620       1630       1640 
LHQNFMHQGN PRFQPKPFYA QADRCATRRC RERCPHPPRG NVSE
Length:1,644
Mass (Da):184,650
Last modified:September 22, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5EE701412E6157A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A8R7A2A8R7_MOUSE
Terminal uridylyltransferase 4
Tut4 Zcchc11
1,648Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQJ6A0A0A0MQJ6_MOUSE
Terminal uridylyltransferase 4
Tut4 Zcchc11
1,006Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A8R1A2A8R1_MOUSE
Terminal uridylyltransferase 4
Tut4 Zcchc11
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2A9H0A2A9H0_MOUSE
Terminal uridylyltransferase 4
Tut4 Zcchc11
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAM23506 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAM25329 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti815D → A in AAI50792 (PubMed:15489334).Curated1
Sequence conflicti815D → A in BAD90397 (Ref. 3) Curated1
Sequence conflicti1336S → R in BAE22125 (PubMed:16141072).Curated1
Sequence conflicti1422S → C in BAE22125 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL626783, AL627238 Genomic DNA Translation: CAM23506.1 Sequence problems.
AL627238, AL626783 Genomic DNA Translation: CAM25329.1 Sequence problems.
BC150791 mRNA Translation: AAI50792.1
AK220327 mRNA Translation: BAD90397.1
AK134388 mRNA Translation: BAE22125.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS18451.1

NCBI Reference Sequences

More...RefSeqi		NP_780681.2, NM_175472.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000043368; ENSMUSP00000044836; ENSMUSG00000034610

Database of genes from NCBI RefSeq genomes

More...GeneIDi		230594

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:230594

UCSC genome browser

More...UCSCi		uc008ubd.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL626783, AL627238 Genomic DNA Translation: CAM23506.1 Sequence problems.
AL627238, AL626783 Genomic DNA Translation: CAM25329.1 Sequence problems.
BC150791 mRNA Translation: AAI50792.1
AK220327 mRNA Translation: BAD90397.1
AK134388 mRNA Translation: BAE22125.1
CCDSiCCDS18451.1
RefSeqiNP_780681.2, NM_175472.3

3D structure databases

SMRiB2RX14
ModBaseiSearch...

Protein-protein interaction databases

BioGridi230978, 1 interactor
DIPiDIP-48571N
IntActiB2RX14, 1 interactor
STRINGi10090.ENSMUSP00000095538

PTM databases

iPTMnetiB2RX14
PhosphoSitePlusiB2RX14

Proteomic databases

EPDiB2RX14
jPOSTiB2RX14
MaxQBiB2RX14
PaxDbiB2RX14
PRIDEiB2RX14

Genome annotation databases

EnsembliENSMUST00000043368; ENSMUSP00000044836; ENSMUSG00000034610
GeneIDi230594
KEGGimmu:230594
UCSCiuc008ubd.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23318
MGIiMGI:2445126 Tut4

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG2277 Eukaryota
COG5260 LUCA
GeneTreeiENSGT00940000156988
HOGENOMiHOG000231134
InParanoidiB2RX14
KOiK13291
OMAiNWIEGFD
OrthoDBi803033at2759

Enzyme and pathway databases

ReactomeiR-MMU-429947 Deadenylation of mRNA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Zcchc11 mouse

Protein Ontology

More...PROi		PR:B2RX14

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000034610 Expressed in 240 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiB2RX14 baseline and differential
GenevisibleiB2RX14 MM

Family and domain databases

InterProiView protein in InterPro
IPR002058 PAP_assoc
IPR002934 Polymerase_NTP_transf_dom
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF01909 NTP_transf_2, 1 hit
PF03828 PAP_assoc, 2 hits
PF00098 zf-CCHC, 2 hits
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 3 hits
SUPFAMiSSF57756 SSF57756, 2 hits
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 3 hits
PS00028 ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTUT4_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2RX14
Secondary accession number(s): A2A8R8, Q3UYT6, Q5DU43
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 22, 2009
Last modified: October 16, 2019
This is version 91 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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