Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 104 (02 Jun 2021)
Sequence version 2 (10 Feb 2021)
Previous versions | rss
Add a publicationFeedback
Protein

ATP-binding cassette sub-family C member 3

Gene

Abcc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (By similarity).

Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity).

Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (PubMed:15814571, PubMed:16225954).

By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi660 – 667ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1319 – 1326ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-159418, Recycling of bile acids and salts
R-MMU-382556, ABC-family proteins mediated transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family C member 3 (EC:7.6.2.-By similarity, EC:7.6.2.2By similarity, EC:7.6.2.3By similarity)
Alternative name(s):
Canalicular multispecific organic anion transporter 2
Multidrug resistance-associated protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abcc3
Synonyms:Cmoat2, Mrp3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1923658, Abcc3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei36 – 56Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini57 – 75CytoplasmicSequence analysisAdd BLAST19
Transmembranei76 – 96Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini97 – 102ExtracellularSequence analysis6
Transmembranei103 – 123Helical; Name=3PROSITE-ProRule annotationAdd BLAST21
Topological domaini124 – 129CytoplasmicSequence analysis6
Transmembranei130 – 150Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini151 – 170ExtracellularSequence analysisAdd BLAST20
Transmembranei171 – 191Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini192 – 301CytoplasmicSequence analysisAdd BLAST110
Transmembranei302 – 324Helical; Name=6PROSITE-ProRule annotationAdd BLAST23
Topological domaini325 – 345ExtracellularSequence analysisAdd BLAST21
Transmembranei346 – 366Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini367 – 419CytoplasmicSequence analysisAdd BLAST53
Transmembranei420 – 440Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini441ExtracellularSequence analysis1
Transmembranei442 – 462Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini463 – 535CytoplasmicSequence analysisAdd BLAST73
Transmembranei536 – 556Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini557 – 567ExtracellularSequence analysisAdd BLAST11
Transmembranei568 – 588Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini589 – 967CytoplasmicSequence analysisAdd BLAST379
Transmembranei968 – 988Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini989 – 1013ExtracellularSequence analysisAdd BLAST25
Transmembranei1014 – 1034Helical; Name=13PROSITE-ProRule annotationAdd BLAST21
Topological domaini1035 – 1071CytoplasmicSequence analysisAdd BLAST37
Transmembranei1072 – 1092Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1093 – 1096ExtracellularSequence analysis4
Transmembranei1097 – 1117Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1118 – 1191CytoplasmicSequence analysisAdd BLAST74
Transmembranei1192 – 1212Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1213 – 1219ExtracellularSequence analysis7
Transmembranei1220 – 1240Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1241 – 1523CytoplasmicSequence analysisAdd BLAST283

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deficient mice do not exhibit any overt phenotype under normal conditions. However when challenged with cholestasis induced by bile duct ligation, increased levels of hepatic bile salts and lower serum levels of bilirubin glucuronide are observed, suggesting that Abcc3 provides an alternative route for removal from the liver of these substrates under cholestatic conditions.2 Publications

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2073683

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003562381 – 1523ATP-binding cassette sub-family C member 3Add BLAST1523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi18N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei903PhosphoserineBy similarity1
Modified residuei906PhosphoserineBy similarity1
Glycosylationi1002N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
B2RX12

MaxQB - The MaxQuant DataBase

More...
MaxQBi
B2RX12

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
B2RX12

PeptideAtlas

More...
PeptideAtlasi
B2RX12

PRoteomics IDEntifications database

More...
PRIDEi
B2RX12

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
295655 [B2RX12-1]
295656 [B2RX12-2]
295657 [B2RX12-3]
373304

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
B2RX12, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
B2RX12

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
B2RX12

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
B2RX12

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected throughout the gastrointestinal tract, liver, lung, pancreas, bladder, gall bladder and at low levels in the adrenal gland.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020865, Expressed in stomach and 176 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000021231

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
B2RX12, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
B2RX12

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini310 – 593ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST284
Domaini626 – 850ABC transporter 1PROSITE-ProRule annotationAdd BLAST225
Domaini967 – 1248ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST282
Domaini1287 – 1519ABC transporter 2PROSITE-ProRule annotationAdd BLAST233

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni903 – 923DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0054, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161624

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000604_27_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
B2RX12

Identification of Orthologs from Complete Genome Data

More...
OMAi
WEDGIEP

Database of Orthologous Groups

More...
OrthoDBi
138195at2759

TreeFam database of animal gene trees

More...
TreeFami
TF105199

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR005292, Multidrug-R_assoc
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00957, MRP_assoc_pro, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: B2RX12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDRLCGSGEL GSKFWDSNLS IYTNTPDLTP CFQNSLLAWV PCIYLWAALP
60 70 80 90 100
CYLFYLRHHQ LGYIVLSWLS RLKTALGVLL WCVSWVDLFY SFHGLIHGSS
110 120 130 140 150
PAPVFFVTPL VVGITMLLAT LLIQYERLRG VQSSGVLIIF WLLCVICAII
160 170 180 190 200
PFRSKILSAL AEGKILDPFR FTTFYIYFAL VFCALILSCF KEKPPLFSPE
210 220 230 240 250
NLDTNPCPEA SAGFFSRLSF WWFTRLAILG YRRPLEDRDL WSLSEEDCSH
260 270 280 290 300
KVVQRLLEAW QKQQNQASRS QTATAEPKIP GEDAVLLKPR PKSKQPSFLR
310 320 330 340 350
ALVRTFTSSL LMSACFNLIQ NLLGFVNPQL LSILIRFISD PTAPTWWGFL
360 370 380 390 400
LAGLMFLSST MQTLILHQYY HCIFVMALRL RTAIIGVIYR KALVITNSVK
410 420 430 440 450
RESTVGEMVN LMSVDAQRFM DVSPFINLLW SAPLQVILAI YFLWQILGPS
460 470 480 490 500
ALAGVAVIVL LIPLNGAVSM KMKTYQVKQM KFKDSRIKLM SEILNGIKVL
510 520 530 540 550
KLYAWEPSFL EQVKGIRQSE LQLLRKGAYL QAISTFIWIC TPFLVTLITL
560 570 580 590 600
GVYVYVDESN VLDAEKAFVS LSLFNILKIP LNMLPQLISG LTQASVSLKR
610 620 630 640 650
IQDFLNQNEL DPQCVERKTI SPGYAITIHN GTFTWAQDLP PTLHSLNIQI
660 670 680 690 700
PKGALVAVVG PVGCGKSSLV SALLGEMEKL EGVVSVKGSV AYVPQQAWIQ
710 720 730 740 750
NCTLQENVLF GQPMNPKRYQ QALETCALLA DLDVLPGGDQ TEIGEKGINL
760 770 780 790 800
SGGQRQRVSL ARAVYSDANI FLLDDPLSAV DSHVAKHIFD QVIGPEGVLA
810 820 830 840 850
GKTRVLVTHG ISFLPQTDFI IVLAGGQVSE MGHYSALLQH DGSFANFLRN
860 870 880 890 900
YAPDEDQEDH EAALQNANEE VLLLEDTLST HTDLTDNEPA IYEVRKQFMR
910 920 930 940 950
EMSSLSSEGE VQNRTMPKKH TNSLEKEALV TKTKETGALI KEEIAETGNV
960 970 980 990 1000
KLSVYWDYAK SMGLCTTLSI CLLYGGQSAA AIGANVWLSA WSNDAEEHGQ
1010 1020 1030 1040 1050
QNKTSVRLGV YAALGILQGL LVMLSAFTMV VGAIQAARLL HEALLHNKIR
1060 1070 1080 1090 1100
SPQSFFDTTP SGRILNRFSK DIYVIDEVLA PTILMLLNSF FTSISTIMVI
1110 1120 1130 1140 1150
VASTPLFMVV VLPLAVLYGF VQRFYVATSR QLKRLESISR SPIFSHFSET
1160 1170 1180 1190 1200
VTGTSVIRAY GRIQDFKVLS DTKVDNNQKS SYPYIASNRW LGVHVEFVGN
1210 1220 1230 1240 1250
CVVLFAALFA VIGRNSLNPG LVGLSVSYAL QVTMALNWMI RMISDLESNI
1260 1270 1280 1290 1300
IAVERVKEYS KTKTEAPWVV ESNRAPEGWP TRGMVEFRNY SVRYRPGLEL
1310 1320 1330 1340 1350
VLKNVTVHVQ GGEKVGIVGR TGAGKSSMTL CLFRILEAAE GEIVIDGLNV
1360 1370 1380 1390 1400
AHIGLHDLRS QLTIIPQDPI LFSGTLRMNL DPFGRYSEED IWRALELSHL
1410 1420 1430 1440 1450
NTFVSSQPAG LDFQCAEGGD NLSVGQRQLV CLARALLRKS RVLVLDEATA
1460 1470 1480 1490 1500
AIDLETDDLI QGTIRTQFED CTVLTIAHRL NTIMDYNRVL VLDKGVVAEF
1510 1520
DSPVNLIAAG GIFYGMAKDA GLA
Length:1,523
Mass (Da):169,223
Last modified:February 10, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF25A63BDE6123AC1
GO
Isoform 2 (identifier: B2RX12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     862-862: Missing.

Show »
Length:1,522
Mass (Da):169,152
Checksum:iFA6E23F737F99D62
GO
Isoform 3 (identifier: B2RX12-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     803-827: Missing.

Show »
Length:1,498
Mass (Da):166,558
Checksum:iF8EC4A0DE64AFFA8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J015A0A0R4J015_MOUSE
ABC-type glutathione-S-conjugate tr...
Abcc3
1,522Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81W → R in AAQ10530 (Ref. 2) Curated1
Sequence conflicti81W → R in AAQ10531 (Ref. 2) Curated1
Sequence conflicti247D → N in BAE33375 (PubMed:16141072).Curated1
Sequence conflicti269R → G in AAX39010 (PubMed:15814571).1
Sequence conflicti269R → G in AAX33774 (PubMed:15814571).1
Sequence conflicti269R → G in AAQ10530 (Ref. 2) 1
Sequence conflicti269R → G in AAQ10531 (Ref. 2) 1
Sequence conflicti269R → G in BAE33375 (PubMed:16141072).1
Sequence conflicti269R → G in AAH48825 (PubMed:15489334).1
Sequence conflicti269R → G in AAI50789 (PubMed:15489334).1
Sequence conflicti742E → G in BAE33375 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036011803 – 827Missing in isoform 3. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_036012862Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY841885 mRNA Translation: AAX39010.1
AY795569 mRNA Translation: AAX33774.1
AF534127 mRNA Translation: AAQ10530.1
AF534128 mRNA Translation: AAQ10531.1
AK149551 mRNA Translation: BAE28953.1
AK155664 mRNA Translation: BAE33375.1
AL645965 Genomic DNA No translation available.
BC048825 mRNA Translation: AAH48825.1
BC150788 mRNA Translation: AAI50789.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25254.1 [B2RX12-2]
CCDS88225.1 [B2RX12-1]

NCBI Reference Sequences

More...
RefSeqi
NP_083876.3, NM_029600.3 [B2RX12-2]
XP_006534491.1, XM_006534428.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000021231; ENSMUSP00000021231; ENSMUSG00000020865 [B2RX12-2]
ENSMUST00000178136; ENSMUSP00000136343; ENSMUSG00000020865 [B2RX12-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
76408

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:76408

UCSC genome browser

More...
UCSCi
uc007kym.1, mouse [B2RX12-2]
uc011ycu.1, mouse [B2RX12-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY841885 mRNA Translation: AAX39010.1
AY795569 mRNA Translation: AAX33774.1
AF534127 mRNA Translation: AAQ10530.1
AF534128 mRNA Translation: AAQ10531.1
AK149551 mRNA Translation: BAE28953.1
AK155664 mRNA Translation: BAE33375.1
AL645965 Genomic DNA No translation available.
BC048825 mRNA Translation: AAH48825.1
BC150788 mRNA Translation: AAI50789.1
CCDSiCCDS25254.1 [B2RX12-2]
CCDS88225.1 [B2RX12-1]
RefSeqiNP_083876.3, NM_029600.3 [B2RX12-2]
XP_006534491.1, XM_006534428.3

3D structure databases

SMRiB2RX12
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021231

Chemistry databases

ChEMBLiCHEMBL2073683

PTM databases

GlyGeniB2RX12, 2 sites
iPTMnetiB2RX12
PhosphoSitePlusiB2RX12
SwissPalmiB2RX12

Proteomic databases

jPOSTiB2RX12
MaxQBiB2RX12
PaxDbiB2RX12
PeptideAtlasiB2RX12
PRIDEiB2RX12
ProteomicsDBi295655 [B2RX12-1]
295656 [B2RX12-2]
295657 [B2RX12-3]
373304

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18128, 311 antibodies

The DNASU plasmid repository

More...
DNASUi
76408

Genome annotation databases

EnsembliENSMUST00000021231; ENSMUSP00000021231; ENSMUSG00000020865 [B2RX12-2]
ENSMUST00000178136; ENSMUSP00000136343; ENSMUSG00000020865 [B2RX12-1]
GeneIDi76408
KEGGimmu:76408
UCSCiuc007kym.1, mouse [B2RX12-2]
uc011ycu.1, mouse [B2RX12-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8714
MGIiMGI:1923658, Abcc3

Phylogenomic databases

eggNOGiKOG0054, Eukaryota
GeneTreeiENSGT00940000161624
HOGENOMiCLU_000604_27_1_1
InParanoidiB2RX12
OMAiWEDGIEP
OrthoDBi138195at2759
TreeFamiTF105199

Enzyme and pathway databases

ReactomeiR-MMU-159418, Recycling of bile acids and salts
R-MMU-382556, ABC-family proteins mediated transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
76408, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Abcc3, mouse

Protein Ontology

More...
PROi
PR:B2RX12
RNActiB2RX12, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020865, Expressed in stomach and 176 other tissues

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR005292, Multidrug-R_assoc
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits
TIGRFAMsiTIGR00957, MRP_assoc_pro, 1 hit
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRP3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2RX12
Secondary accession number(s): J3QML2
, Q3U1W8, Q56PH0, Q59DK9, Q59DL0, Q5SUF4, Q80ZK8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: February 10, 2021
Last modified: June 2, 2021
This is version 104 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again