Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 81 (31 Jul 2019)
Sequence version 1 (01 Jul 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

Arhgap21 protein

Gene

Arhgap21

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Arhgap21 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arhgap21Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918685 Arhgap21

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
B2RWX1

PRoteomics IDEntifications database

More...
PRIDEi
B2RWX1

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
B2RWX1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 164PDZInterPro annotationAdd BLAST110
Domaini934 – 1043PHInterPro annotationAdd BLAST110
Domaini1150 – 1342Rho-GAPInterPro annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 53DisorderedSequence analysisAdd BLAST29
Regioni219 – 238DisorderedSequence analysisAdd BLAST20
Regioni335 – 374DisorderedSequence analysisAdd BLAST40
Regioni508 – 528DisorderedSequence analysisAdd BLAST21
Regioni582 – 656DisorderedSequence analysisAdd BLAST75
Regioni683 – 711DisorderedSequence analysisAdd BLAST29
Regioni861 – 888DisorderedSequence analysisAdd BLAST28
Regioni911 – 930DisorderedSequence analysisAdd BLAST20
Regioni1089 – 1129DisorderedSequence analysisAdd BLAST41
Regioni1382 – 1405DisorderedSequence analysisAdd BLAST24
Regioni1421 – 1640DisorderedSequence analysisAdd BLAST220
Regioni1659 – 1803DisorderedSequence analysisAdd BLAST145
Regioni1855 – 1954DisorderedSequence analysisAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi598 – 613PolarSequence analysisAdd BLAST16
Compositional biasi683 – 705PolarSequence analysisAdd BLAST23
Compositional biasi861 – 875PolarSequence analysisAdd BLAST15
Compositional biasi1098 – 1123PolyampholyteSequence analysisAdd BLAST26
Compositional biasi1384 – 1403PolarSequence analysisAdd BLAST20
Compositional biasi1430 – 1469PolyampholyteSequence analysisAdd BLAST40
Compositional biasi1477 – 1505PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1533 – 1561PolarSequence analysisAdd BLAST29
Compositional biasi1568 – 1605PolarSequence analysisAdd BLAST38
Compositional biasi1609 – 1632PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1664 – 1687PolarSequence analysisAdd BLAST24
Compositional biasi1688 – 1728PolyampholyteSequence analysisAdd BLAST41
Compositional biasi1751 – 1771PolyampholyteSequence analysisAdd BLAST21
Compositional biasi1875 – 1941PolarSequence analysisAdd BLAST67

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KD1S Eukaryota
ENOG410YY7B LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17820 PDZ_6, 1 hit
PF15410 PH_9, 1 hit
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

B2RWX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATHWTGLPE EDGDKLKACG AASACEVSKN KDGKDQGEPV SPSEDEPFSW
60 70 80 90 100
PGPKTVMLKR TSQGFGFTLR HFIVYPPESA IQFSYKDEEN GNRGGKQRNR
110 120 130 140 150
LEPMDTIFVK QVKEGGPAFE AGLCTGDRII KVNGESVIGK TYSQVIALIQ
160 170 180 190 200
NSDTTLELSV MPKDEDILQV LQFTKDVTAL AYSQDAYLKG NEAYSGNARN
210 220 230 240 250
IPEPPPVCYP WLPSTPSATA QPVETCPPDS LPNKQQTSAP VLTQPGRAYR
260 270 280 290 300
MEIQVPPSPT DVAKSNTAVC VCNESVRTVI VPSEKVVDLL ANRNNPSGPS
310 320 330 340 350
HRTEEVRYGV NEQASTKAAS RTTSPASVPT AHLIHQTTGS RSLEPSGILL
360 370 380 390 400
KSGNYSGHSE GISSSRSQAV DSPPVSVNHY SANSHQHIDW KNYKTYKEYI
410 420 430 440 450
DNRRLHIGCR TIQERLDSLR AASQSAADYN QVVPTRTTLQ VRRRSTSHDR
460 470 480 490 500
VPQSVQIRQR SVSQERLEDS VLMKYCPRSA SQGALTSPPV SFNNHRTRSW
510 520 530 540 550
DYIEGQTEAT ATVNSESQIP DSNGERKQTY KWSGFTEQDD RRGIHERPRQ
560 570 580 590 600
QEMHKPFRGS NLTVAPVVNS DNRRLVGRGV GPVSQFKKIP PDLRPPHSNR
610 620 630 640 650
NFPTTTGVSL QRGIAQDRSP LVKVRSNSLK VPPPPVSKPS FSQHSLASMK
660 670 680 690 700
DQRPVNHLHQ HSVLSQQTQF RSESTFEHQL ETEVSSCLPG TSAKTSPQLS
710 720 730 740 750
ENLGTSDLEL PAIPRNGDIN LQEAEIQQPD VLDNKESVIL REKPQSGRQT
760 770 780 790 800
PQPLRHQSYI LAVNDQETGS DTTCWLPNDA RREVHIKRME ERKASSTSPP
810 820 830 840 850
GDSLASIPFI DEPTSPSIDH EIAHIPASAV ISASTAHVPS IATVPPSLTT
860 870 880 890 900
SAPLIRRQLS HDQESVGPPS LDGQHSSKTE RSKSYDEGLD DYREDAKLSF
910 920 930 940 950
KHVSSLKGIK ITDSQKSSED SGSRKGSSSE VFSDAAREGW LQFRPLVTDK
960 970 980 990 1000
GKRVGGSIRP WKQMYVVLRG HSLYLYKDRR EQTTPSEEEQ PISVNACLID
1010 1020 1030 1040 1050
ISYSETKRRN VFRLTTSDCE CLFQAEDRDD MLSWIKTIQE SSNLNEEDTG
1060 1070 1080 1090 1100
VTNRDLISRR IKEYNSLLSK TEQLPKTPRQ SLSIRQTLLG AKSEPKTQSP
1110 1120 1130 1140 1150
HSPKEESERK LLSKDDTSPP KDKGTWRRGI PSIVRKTFEK KPAATGTFGV
1160 1170 1180 1190 1200
RLDDCPPAHT NRYIPLIVDI CCKLVEERGL EYTGIYRVPG NNAAISSMQE
1210 1220 1230 1240 1250
ELNKGMADID IQDDKWRDLN VISSLLKSFF RKLPEPLFTN DKYADFIEAN
1260 1270 1280 1290 1300
RKEDPLDRLR TLKRLIHDLP EHHFETLKFL SAHLKTVAEN SEKNKMEPRN
1310 1320 1330 1340 1350
LAIVFGPTLV RTSEDNMTHM VTHMPDQYKI VETLIQHHDW FFTEEGAEEP
1360 1370 1380 1390 1400
LTAVQEENTV DSQPVPNIDH LLTNIGRTGV LPGDVSDSAT SDSAKSKGSW
1410 1420 1430 1440 1450
GSGKDQYSRE LLVSSIFAAA SRKRKKPKEK AQPSSSEDEL DSVFFKKENT
1460 1470 1480 1490 1500
EQSHSEIKEE SKRESETSGS KQRVVVAKES NTKKDSGTTK EEKKIPWEEP
1510 1520 1530 1540 1550
SPPHSSKRNR SPTLSCRLAM LKEGPRSLLT QKPHCEETGS DSGTLLSTSS
1560 1570 1580 1590 1600
QASLLRSSTK KSTSPETKHS EFLSIAGTTT SDYSTTSSTT YLTSLDSSRL
1610 1620 1630 1640 1650
SPEVQSVAES KGDEADDERS ELVSEGRPVE TDSESEFPVF PATLTSDRLF
1660 1670 1680 1690 1700
RGKFQDVARV SRRNSEGSEA SCTEGSLTPS LDSRRQQFSS HRLIECDTLS
1710 1720 1730 1740 1750
RKKSARFKSD SGSPGDTRTE KETPALAKMF DVMKKGKSTG SLLTPSRSES
1760 1770 1780 1790 1800
EKQEATWKTK IADRLKLRPR APADDMFGVG NQKPTAETAK RKNIKRRHTL
1810 1820 1830 1840 1850
GGHRDATEIS VLSFWKAHEQ SADKESELSA VNRLKPKCSA QDLSISDWLA
1860 1870 1880 1890 1900
RERVRTSASD LSRGEGLEPQ AESPSVLGTP ISTHSPPSQQ PEARVAATST
1910 1920 1930 1940 1950
LASTSQSPLF TPPQSPDQIN RESFQNMSQN ASSTANIHPH KQSESPDTKA

ETPP
Length:1,954
Mass (Da):216,806
Last modified:July 1, 2008 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B1DDF7BC1317500
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC150741 mRNA Translation: AAI50742.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC150741 mRNA Translation: AAI50742.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiB2RWX1

Proteomic databases

PeptideAtlasiB2RWX1
PRIDEiB2RWX1

Organism-specific databases

MGIiMGI:1918685 Arhgap21

Phylogenomic databases

eggNOGiENOG410KD1S Eukaryota
ENOG410YY7B LUCA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Arhgap21 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR041681 PH_9
IPR001849 PH_domain
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF17820 PDZ_6, 1 hit
PF15410 PH_9, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiB2RWX1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: B2RWX1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 31, 2019
This is version 81 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again