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Protein

T-cell activation Rho GTPase-activating protein

Gene

Tagap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a GTPase-activating protein. May play a role in transmission ratio distortion (TRD) in mouse, in which heterozygous males for t-locus transmit their t-carrying chromosome to 95% or more of their offspring.1 Publication

Caution

Previously thought to be the same gene as Tagap1. These are distinct loci that encode proteins with identical C-termini but each with a unique N-terminus.Curated

GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

GO - Biological processi

  • defense response to virus Source: MGI
  • signal transduction Source: InterPro

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell activation Rho GTPase-activating protein
Alternative name(s):
T-cell activation GTPase-activating protein
Gene namesi
Name:Tagap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3615484 Tagap

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000567201 – 714T-cell activation Rho GTPase-activating proteinAdd BLAST714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei398PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB2RWW0
PRIDEiB2RWW0

PTM databases

iPTMnetiB2RWW0
PhosphoSitePlusiB2RWW0

Expressioni

Tissue specificityi

Highly expressed in testis.1 Publication

Developmental stagei

Expressed in testis at 7 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000033450 Expressed in 18 organ(s), highest expression level in spleen
GenevisibleiB2RWW0 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047431

Structurei

3D structure databases

ProteinModelPortaliB2RWW0
SMRiB2RWW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 277Rho-GAPPROSITE-ProRule annotationAdd BLAST190

Phylogenomic databases

eggNOGiKOG4724 Eukaryota
ENOG410YV4E LUCA
GeneTreeiENSGT00530000063299
HOGENOMiHOG000139745
HOVERGENiHBG071607
InParanoidiB2RWW0
KOiK20654
OMAiWPFLMRR
OrthoDBiEOG091G02C4
PhylomeDBiB2RWW0
TreeFamiTF331062

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit

Sequencei

Sequence statusi: Complete.

B2RWW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLISSLDGS KTLNANNMET LIECQSEGDI KVPPLLTSCE SEDSICQLTE
60 70 80 90 100
IKKRKKVLSW PSLMRKLSPS SDFSGSLEPE LKVSLFDQPL SIICGENDTL
110 120 130 140 150
PRPIQDILTI LCLKGPSTEG IFRKAASEKA RKELKEGLNC GVSVNLKQLP
160 170 180 190 200
VHLLAVVFKD FLRGIPLKLL SCDLFEDWMG ALEKPTEEDR IEALKQVAGG
210 220 230 240 250
LPRPNLLLLR HLLYVLHLIS KNAEVNKMDS SNLAICIGPN MLTLKNDQSL
260 270 280 290 300
SFQAQKDLNN KVKILVEFLI DNCFEIFGEN IRTRSRITSD DSLEHTDSSD
310 320 330 340 350
VSTLQNDSAY DSNDPDVEPT SGAASPNRQL EGPTPTMAGL DTRGQRDTCE
360 370 380 390 400
SSSESSVSMV VRLKSSIVQQ DRRFSEPNMS PSRECLVGPT SKQKLARSED
410 420 430 440 450
SFTLSQDASC SEGDEAEDPF TEEVFPAVDS KPKRPVDLKI KNWTQGLASP
460 470 480 490 500
QGHITKAFSR SSPGESLGSS PVPSPSCPKR NFFTRHQSFT TKTDKTKPQR
510 520 530 540 550
EIRKHSMSFS FASHKKVLPR TSSIGSEKSK DFSRDQLQKD LRKESQLSGR
560 570 580 590 600
IVQENESEIQ SQTSLGFSLS GTWALSVDNT FQLVDMRKPG SPPSYEEAIY
610 620 630 640 650
YQTSGLTAYG GQTVGSMRSR MFKPSTAVPP VPSHHGGDLS EGTPGGHRLS
660 670 680 690 700
SVTEHWTHSQ TVHVSIETQG RSELHQLRTV SESMQKAKLD CLGPQHSHLV
710
FEADQLCCAR ESYI
Length:714
Mass (Da):78,920
Last modified:July 28, 2009 - v2
Checksum:i35925DE6885B4CAD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti345Q → H in AAI50729 (PubMed:16116428).Curated1
Sequence conflicti387V → M in AAI50729 (PubMed:16116428).Curated1
Sequence conflicti396A → T in AAI50729 (PubMed:16116428).Curated1
Sequence conflicti703A → V in AAI50729 (PubMed:16116428).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC150728 mRNA Translation: AAI50729.1
BC030886 mRNA Translation: AAH30886.1
BC039780 mRNA Translation: AAH39780.1
CCDSiCCDS28379.1
RefSeqiNP_666080.1, NM_145968.2
UniGeneiMm.119680

Genome annotation databases

EnsembliENSMUST00000036370; ENSMUSP00000047431; ENSMUSG00000033450
GeneIDi72536
KEGGimmu:72536
UCSCiuc008air.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC150728 mRNA Translation: AAI50729.1
BC030886 mRNA Translation: AAH30886.1
BC039780 mRNA Translation: AAH39780.1
CCDSiCCDS28379.1
RefSeqiNP_666080.1, NM_145968.2
UniGeneiMm.119680

3D structure databases

ProteinModelPortaliB2RWW0
SMRiB2RWW0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047431

PTM databases

iPTMnetiB2RWW0
PhosphoSitePlusiB2RWW0

Proteomic databases

PaxDbiB2RWW0
PRIDEiB2RWW0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036370; ENSMUSP00000047431; ENSMUSG00000033450
GeneIDi72536
KEGGimmu:72536
UCSCiuc008air.2 mouse

Organism-specific databases

CTDi117289
MGIiMGI:3615484 Tagap

Phylogenomic databases

eggNOGiKOG4724 Eukaryota
ENOG410YV4E LUCA
GeneTreeiENSGT00530000063299
HOGENOMiHOG000139745
HOVERGENiHBG071607
InParanoidiB2RWW0
KOiK20654
OMAiWPFLMRR
OrthoDBiEOG091G02C4
PhylomeDBiB2RWW0
TreeFamiTF331062

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Miscellaneous databases

PROiPR:B2RWW0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033450 Expressed in 18 organ(s), highest expression level in spleen
GenevisibleiB2RWW0 MM

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAGAP_MOUSE
AccessioniPrimary (citable) accession number: B2RWW0
Secondary accession number(s): Q8K2L9, Q920D6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 28, 2009
Last modified: November 7, 2018
This is version 69 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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