Klk12

Protein namesⁱ	Submitted name: Kallikrein-related-peptidase 12Imported
Gene namesⁱ	Name:Klk12Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1916761 Klk12

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST		17
ChainⁱPRO_5015087156	18 – 247	Sequence analysisAdd BLAST		230

Keywords - PTMⁱ

Disulfide bondSAAS annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000044430 Expressed in 35 organ(s), highest expression level in liver

Bgeeⁱ

ENSMUSG00000044430 Expressed in 35 organ(s), highest expression level in liver

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000014063

STRINGⁱ

10090.ENSMUSP00000014063

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	22 – 245	Peptidase S1InterPro annotationAdd BLAST		224

Sequence similaritiesⁱ

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3627 Eukaryota COG5640 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118862
HOGENOMⁱ	HOG000251820
HOVERGENⁱ	HBG013304
KEGG Orthology (KO) More...KOⁱ	K09621
OMAⁱ	CRAVFPG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AH5
TreeFamⁱ	TF331065

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00190 Tryp_SPc, 1 hit
InterProⁱ	View protein in InterPro IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00089 Trypsin, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit
PROSITEⁱ	View protein in PROSITE PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

B2RVZ0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRFSILLLLC AVGLSQADRE KIYNGVECVK NSQPWQVGLF HGKYLRCGGV 
        60         70         80         90        100
LVDRKWVLTA AHCRDKYVVR LGEHSLTKLD WTEQLRHTTF SITHPSYQGA 
       110        120        130        140        150
YQNHEHDLRL LRLNRPIHLT RAVRPVALPS SCVTTGAMCH VSGWGTTNKP 
       160        170        180        190        200
WDPFPDRLQC LNLSTVSNET CRAVFPGRVT ENMLCAGGEA GKDACQGDSG 
       210        220        230        240 
GPLVCGGVLQ GLVSWGSVGP CGQKGIPGVY TKVCKYTDWI RIVIRNN

Length:247

Mass (Da):27,305

Last modified:July 1, 2008 - v1

Checksum:ⁱ79DE6442D2E77CE3

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC151989 Genomic DNA No translation available. BC147442 mRNA Translation: AAI47443.1 BC147463 mRNA Translation: AAI47464.1
NCBI Reference Sequences More...RefSeqⁱ	NP_081373.1, NM_027097.1 XP_006541237.1, XM_006541174.3 XP_017167777.1, XM_017312288.1
UniGeneⁱ	Mm.20163

Genome annotation databases

Ensemblⁱ	ENSMUST00000014063; ENSMUSP00000014063; ENSMUSG00000044430 ENSMUST00000107970; ENSMUSP00000103604; ENSMUSG00000044430
GeneIDⁱ	69511
KEGGⁱ	mmu:69511
UCSC genome browser More...UCSCⁱ	uc012fji.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
B2RVZ0	Kallikrein k		MOUSE		286	UniRef100_A0A1R3UFC6
MCG144712 (Fragment)		MOUSE		234

Protein	Similar proteins		Species	Score	Length	Source
B2RVZ0	Kallikrein related-peptidase 12		MOUSE		247	UniRef90_A0A0B6VPC8
Kallikrein k		RAT		247
UPI000A314A33		MUSCR		247
UPI000A3094EA		MUSPA		247
Kallikrein k		MOUSE		286
+3

Protein	Similar proteins		Species	Score	Length	Source
B2RVZ0	Kallikrein-12		HUMAN		248	UniRef50_Q9UKR0
Kallikrein related peptidase 12		MACFA		248
Uncharacterized protein		MACNE		248
Uncharacterized protein		NOMLE		248
Uncharacterized protein		CERAT		248
+68

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC151989 Genomic DNA No translation available. BC147442 mRNA Translation: AAI47443.1 BC147463 mRNA Translation: AAI47464.1
RefSeqⁱ	NP_081373.1, NM_027097.1 XP_006541237.1, XM_006541174.3 XP_017167777.1, XM_017312288.1
UniGeneⁱ	Mm.20163

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000014063

STRINGⁱ

10090.ENSMUSP00000014063

Protein family/group databases

MEROPSⁱ	S01.020

MEROPSⁱ

S01.020

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000014063; ENSMUSP00000014063; ENSMUSG00000044430 ENSMUST00000107970; ENSMUSP00000103604; ENSMUSG00000044430
GeneIDⁱ	69511
KEGGⁱ	mmu:69511
UCSCⁱ	uc012fji.1 mouse

Organism-specific databases

CTDⁱ	43849
MGIⁱ	MGI:1916761 Klk12

Phylogenomic databases

eggNOGⁱ	KOG3627 Eukaryota COG5640 LUCA
GeneTreeⁱ	ENSGT00760000118862
HOGENOMⁱ	HOG000251820
HOVERGENⁱ	HBG013304
KOⁱ	K09621
OMAⁱ	CRAVFPG
OrthoDBⁱ	EOG091G0AH5
TreeFamⁱ	TF331065

Enzyme and pathway databases

Reactomeⁱ	R-MMU-6809371 Formation of the cornified envelope

Reactomeⁱ

R-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000044430 Expressed in 35 organ(s), highest expression level in liver

Bgeeⁱ

ENSMUSG00000044430 Expressed in 35 organ(s), highest expression level in liver

Family and domain databases

CDDⁱ	cd00190 Tryp_SPc, 1 hit
InterProⁱ	View protein in InterPro IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom IPR018114 TRYPSIN_HIS IPR033116 TRYPSIN_SER
Pfamⁱ	View protein in Pfam PF00089 Trypsin, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit
PROSITEⁱ	View protein in PROSITE PS50240 TRYPSIN_DOM, 1 hit PS00134 TRYPSIN_HIS, 1 hit PS00135 TRYPSIN_SER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B2RVZ0_MOUSE
Accessionⁱ	B2RVZ0Primary (citable) accession number: B2RVZ0
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 1, 2008
	Last sequence update:	July 1, 2008
	Last modified:	November 7, 2018
	This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B2RVZ0 (B2RVZ0_MOUSE)

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Kallikrein-related-peptidase 12

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ