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UniProtKB - B2RVZ0 (B2RVZ0_MOUSE)
Protein
Submitted name:
Kallikrein-related-peptidase 12
Gene
Klk12
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- peptidase activity Source: MGI
- serine-type endopeptidase activity Source: InterPro
- serine-type peptidase activity Source: MGI
GO - Biological processi
- proteolysis Source: MGI
Keywordsi
Molecular function | Hydrolase, Protease, Serine proteaseUniRule annotation |
Protein family/group databases
MEROPSi | S01.020 |
Names & Taxonomyi
Protein namesi | Submitted name: Kallikrein-related-peptidase 12Imported |
Gene namesi | Name:Klk12Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1916761, Klk12 |
VEuPathDBi | HostDB:ENSMUSG00000044430 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5015087156 | 18 – 247 | Sequence analysisAdd BLAST | 230 |
Keywords - PTMi
Disulfide bondARBA annotationProteomic databases
ProteomicsDBi | 334728 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000044430, Expressed in esophagus and 70 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 245 | Peptidase S1InterPro annotationAdd BLAST | 224 |
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT01020000230389 |
HOGENOMi | CLU_006842_1_1_1 |
OMAi | PCGQEGI |
OrthoDBi | 1314811at2759 |
TreeFami | TF331065 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
B2RVZ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRFSILLLLC AVGLSQADRE KIYNGVECVK NSQPWQVGLF HGKYLRCGGV
60 70 80 90 100
LVDRKWVLTA AHCRDKYVVR LGEHSLTKLD WTEQLRHTTF SITHPSYQGA
110 120 130 140 150
YQNHEHDLRL LRLNRPIHLT RAVRPVALPS SCVTTGAMCH VSGWGTTNKP
160 170 180 190 200
WDPFPDRLQC LNLSTVSNET CRAVFPGRVT ENMLCAGGEA GKDACQGDSG
210 220 230 240
GPLVCGGVLQ GLVSWGSVGP CGQKGIPGVY TKVCKYTDWI RIVIRNN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC147442 mRNA Translation: AAI47443.1 BC147463 mRNA Translation: AAI47464.1 |
RefSeqi | NP_081373.1, NM_027097.1 XP_006541237.1, XM_006541174.3 XP_017167777.1, XM_017312288.1 |
Genome annotation databases
Ensembli | ENSMUST00000014063; ENSMUSP00000014063; ENSMUSG00000044430 ENSMUST00000107970; ENSMUSP00000103604; ENSMUSG00000044430 |
GeneIDi | 69511 |
KEGGi | mmu:69511 |
UCSCi | uc012fji.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC147442 mRNA Translation: AAI47443.1 BC147463 mRNA Translation: AAI47464.1 |
RefSeqi | NP_081373.1, NM_027097.1 XP_006541237.1, XM_006541174.3 XP_017167777.1, XM_017312288.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000103604 |
Protein family/group databases
MEROPSi | S01.020 |
Proteomic databases
ProteomicsDBi | 334728 |
Protocols and materials databases
Antibodypediai | 18973, 137 antibodies from 27 providers |
DNASUi | 69511 |
Genome annotation databases
Ensembli | ENSMUST00000014063; ENSMUSP00000014063; ENSMUSG00000044430 ENSMUST00000107970; ENSMUSP00000103604; ENSMUSG00000044430 |
GeneIDi | 69511 |
KEGGi | mmu:69511 |
UCSCi | uc012fji.1, mouse |
Organism-specific databases
CTDi | 43849 |
MGIi | MGI:1916761, Klk12 |
VEuPathDBi | HostDB:ENSMUSG00000044430 |
Phylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT01020000230389 |
HOGENOMi | CLU_006842_1_1_1 |
OMAi | PCGQEGI |
OrthoDBi | 1314811at2759 |
TreeFami | TF331065 |
Miscellaneous databases
BioGRID-ORCSi | 69511, 1 hit in 64 CRISPR screens |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000044430, Expressed in esophagus and 70 other tissues |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B2RVZ0_MOUSE | |
Accessioni | B2RVZ0Primary (citable) accession number: B2RVZ0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 1, 2008 |
Last sequence update: | July 1, 2008 | |
Last modified: | January 19, 2022 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |