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Protein
Submitted name:

Kallikrein-related-peptidase 12

Gene

Klk12

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-6809371 Formation of the cornified envelope

Protein family/group databases

MEROPSiS01.020

Names & Taxonomyi

Protein namesi
Submitted name:
Kallikrein-related-peptidase 12Imported
Gene namesi
Name:Klk12Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1916761 Klk12

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_501508715618 – 247Sequence analysisAdd BLAST230

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000044430 Expressed in 35 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000014063

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 245Peptidase S1InterPro annotationAdd BLAST224

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00920000149034
HOGENOMiHOG000251820
HOVERGENiHBG013304
KOiK09621
OMAiCRAVFPG
OrthoDBiEOG091G0AH5
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

B2RVZ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFSILLLLC AVGLSQADRE KIYNGVECVK NSQPWQVGLF HGKYLRCGGV
60 70 80 90 100
LVDRKWVLTA AHCRDKYVVR LGEHSLTKLD WTEQLRHTTF SITHPSYQGA
110 120 130 140 150
YQNHEHDLRL LRLNRPIHLT RAVRPVALPS SCVTTGAMCH VSGWGTTNKP
160 170 180 190 200
WDPFPDRLQC LNLSTVSNET CRAVFPGRVT ENMLCAGGEA GKDACQGDSG
210 220 230 240
GPLVCGGVLQ GLVSWGSVGP CGQKGIPGVY TKVCKYTDWI RIVIRNN
Length:247
Mass (Da):27,305
Last modified:July 1, 2008 - v1
Checksum:i79DE6442D2E77CE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151989 Genomic DNA No translation available.
BC147442 mRNA Translation: AAI47443.1
BC147463 mRNA Translation: AAI47464.1
RefSeqiNP_081373.1, NM_027097.1
XP_006541237.1, XM_006541174.3
XP_017167777.1, XM_017312288.1
UniGeneiMm.20163

Genome annotation databases

EnsembliENSMUST00000014063; ENSMUSP00000014063; ENSMUSG00000044430
ENSMUST00000107970; ENSMUSP00000103604; ENSMUSG00000044430
GeneIDi69511
KEGGimmu:69511
UCSCiuc012fji.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151989 Genomic DNA No translation available.
BC147442 mRNA Translation: AAI47443.1
BC147463 mRNA Translation: AAI47464.1
RefSeqiNP_081373.1, NM_027097.1
XP_006541237.1, XM_006541174.3
XP_017167777.1, XM_017312288.1
UniGeneiMm.20163

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000014063

Protein family/group databases

MEROPSiS01.020

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000014063; ENSMUSP00000014063; ENSMUSG00000044430
ENSMUST00000107970; ENSMUSP00000103604; ENSMUSG00000044430
GeneIDi69511
KEGGimmu:69511
UCSCiuc012fji.1 mouse

Organism-specific databases

CTDi43849
MGIiMGI:1916761 Klk12

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00920000149034
HOGENOMiHOG000251820
HOVERGENiHBG013304
KOiK09621
OMAiCRAVFPG
OrthoDBiEOG091G0AH5
TreeFamiTF331065

Enzyme and pathway databases

ReactomeiR-MMU-6809371 Formation of the cornified envelope

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044430 Expressed in 35 organ(s), highest expression level in liver

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB2RVZ0_MOUSE
AccessioniPrimary (citable) accession number: B2RVZ0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: September 12, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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