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Protein

Transmembrane protein 182

Gene

Tmem182

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 182
Gene namesi
Name:Tmem182
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1923725 Tmem182

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 114ExtracellularSequence analysisAdd BLAST88
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 153CytoplasmicSequence analysisAdd BLAST18
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 200ExtracellularSequence analysisAdd BLAST26
Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 229CytoplasmicSequence analysis8

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000036925727 – 229Transmembrane protein 182Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi68N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiB2RVY9
PaxDbiB2RVY9
PRIDEiB2RVY9

Expressioni

Tissue specificityi

Highly expressed in white adipose tissues (WAT), with 10-fold to 20-fold higher levels than in brown adipose tissue (BAT). Also expressed in skeletal muscle, heart and lung. Lower relative levels of expression in kidney, spleen, testis, brain and liver.1 Publication

Developmental stagei

Upregulated in adipogenesis and also markedly up-regulated during in vitro myogenesis of C2C12 myoblasts to myocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000079588 Expressed in 103 organ(s), highest expression level in quadriceps femoris
GenevisibleiB2RVY9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110413

Structurei

3D structure databases

ProteinModelPortaliB2RVY9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM182 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQ09 Eukaryota
ENOG4111FRX LUCA
GeneTreeiENSGT00390000017581
HOGENOMiHOG000043110
InParanoidiB2RVY9
OMAiTEVGKCS
OrthoDBiEOG091G0OD5
PhylomeDBiB2RVY9
TreeFamiTF331344

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR026763 TMEM182
PANTHERiPTHR32012 PTHR32012, 1 hit
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B2RVY9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLNVAVFFG ALFGALGVLL FLVAFGSDYW LLATEVGRCS GEQNIENITF
60 70 80 90 100
HHEGFFWRCW FSGVVEENNS NIWKFWYTNQ PPSKNCTHAY LSPYPFMRGE
110 120 130 140 150
HNSTSYDSAI IYRGFWAVLL LLGVVAALTA SFLIICAAPF SSHFLYKAGG
160 170 180 190 200
GSYIASGVLF SLVVILYVIW VQAVADMESY RALRMRDCWE FTPSILYGWS
210 220
FFLAPAGVFF SLLAGLLFLV VGRHIQIHH
Length:229
Mass (Da):25,845
Last modified:July 1, 2008 - v1
Checksum:i35617F40902545A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466536 Genomic DNA Translation: EDL14585.1
BC147440 mRNA Translation: AAI47441.1
BC147458 mRNA Translation: AAI47459.1
BC147740 mRNA Translation: AAI47741.1
BC147743 mRNA Translation: AAI47744.1
CCDSiCCDS35550.1
RefSeqiNP_001074667.1, NM_001081198.1
UniGeneiMm.334678
Mm.395273

Genome annotation databases

EnsembliENSMUST00000114765; ENSMUSP00000110413; ENSMUSG00000079588
GeneIDi381339
KEGGimmu:381339
UCSCiuc007auq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH466536 Genomic DNA Translation: EDL14585.1
BC147440 mRNA Translation: AAI47441.1
BC147458 mRNA Translation: AAI47459.1
BC147740 mRNA Translation: AAI47741.1
BC147743 mRNA Translation: AAI47744.1
CCDSiCCDS35550.1
RefSeqiNP_001074667.1, NM_001081198.1
UniGeneiMm.334678
Mm.395273

3D structure databases

ProteinModelPortaliB2RVY9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110413

Proteomic databases

MaxQBiB2RVY9
PaxDbiB2RVY9
PRIDEiB2RVY9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114765; ENSMUSP00000110413; ENSMUSG00000079588
GeneIDi381339
KEGGimmu:381339
UCSCiuc007auq.1 mouse

Organism-specific databases

CTDi130827
MGIiMGI:1923725 Tmem182

Phylogenomic databases

eggNOGiENOG410IQ09 Eukaryota
ENOG4111FRX LUCA
GeneTreeiENSGT00390000017581
HOGENOMiHOG000043110
InParanoidiB2RVY9
OMAiTEVGKCS
OrthoDBiEOG091G0OD5
PhylomeDBiB2RVY9
TreeFamiTF331344

Miscellaneous databases

PROiPR:B2RVY9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079588 Expressed in 103 organ(s), highest expression level in quadriceps femoris
GenevisibleiB2RVY9 MM

Family and domain databases

InterProiView protein in InterPro
IPR004031 PMP22/EMP/MP20/Claudin
IPR026763 TMEM182
PANTHERiPTHR32012 PTHR32012, 1 hit
PfamiView protein in Pfam
PF13903 Claudin_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM182_MOUSE
AccessioniPrimary (citable) accession number: B2RVY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: July 1, 2008
Last modified: September 12, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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