UniProtKB - B2RVY9 (TM182_MOUSE)
Protein
Transmembrane protein 182
Gene
Tmem182
Organism
Mus musculus (Mouse)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 182 |
Gene namesi | Name:Tmem182 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1923725 Tmem182 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 114 | ExtracellularSequence analysisAdd BLAST | 88 | |
Transmembranei | 115 – 135 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 136 – 153 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 154 – 174 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 175 – 200 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 222 – 229 | CytoplasmicSequence analysis | 8 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000369257 | 27 – 229 | Transmembrane protein 182Add BLAST | 203 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 47 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 68 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 85 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | B2RVY9 |
PaxDbi | B2RVY9 |
PRIDEi | B2RVY9 |
Expressioni
Tissue specificityi
Highly expressed in white adipose tissues (WAT), with 10-fold to 20-fold higher levels than in brown adipose tissue (BAT). Also expressed in skeletal muscle, heart and lung. Lower relative levels of expression in kidney, spleen, testis, brain and liver.1 Publication
Developmental stagei
Upregulated in adipogenesis and also markedly up-regulated during in vitro myogenesis of C2C12 myoblasts to myocytes.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000079588 Expressed in 103 organ(s), highest expression level in quadriceps femoris |
Genevisiblei | B2RVY9 MM |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM182 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IQ09 Eukaryota ENOG4111FRX LUCA |
GeneTreei | ENSGT00390000017581 |
HOGENOMi | HOG000043110 |
InParanoidi | B2RVY9 |
OMAi | TEVGKCS |
OrthoDBi | 1246131at2759 |
PhylomeDBi | B2RVY9 |
TreeFami | TF331344 |
Family and domain databases
InterProi | View protein in InterPro IPR004031 PMP22/EMP/MP20/Claudin IPR026763 TMEM182 |
PANTHERi | PTHR32012 PTHR32012, 1 hit |
Pfami | View protein in Pfam PF13903 Claudin_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
B2RVY9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLNVAVFFG ALFGALGVLL FLVAFGSDYW LLATEVGRCS GEQNIENITF
60 70 80 90 100
HHEGFFWRCW FSGVVEENNS NIWKFWYTNQ PPSKNCTHAY LSPYPFMRGE
110 120 130 140 150
HNSTSYDSAI IYRGFWAVLL LLGVVAALTA SFLIICAAPF SSHFLYKAGG
160 170 180 190 200
GSYIASGVLF SLVVILYVIW VQAVADMESY RALRMRDCWE FTPSILYGWS
210 220
FFLAPAGVFF SLLAGLLFLV VGRHIQIHH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH466536 Genomic DNA Translation: EDL14585.1 BC147440 mRNA Translation: AAI47441.1 BC147458 mRNA Translation: AAI47459.1 BC147740 mRNA Translation: AAI47741.1 BC147743 mRNA Translation: AAI47744.1 |
CCDSi | CCDS35550.1 |
RefSeqi | NP_001074667.1, NM_001081198.1 |
UniGenei | Mm.334678 Mm.395273 |
Genome annotation databases
Ensembli | ENSMUST00000114765; ENSMUSP00000110413; ENSMUSG00000079588 |
GeneIDi | 381339 |
KEGGi | mmu:381339 |
UCSCi | uc007auq.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH466536 Genomic DNA Translation: EDL14585.1 BC147440 mRNA Translation: AAI47441.1 BC147458 mRNA Translation: AAI47459.1 BC147740 mRNA Translation: AAI47741.1 BC147743 mRNA Translation: AAI47744.1 |
CCDSi | CCDS35550.1 |
RefSeqi | NP_001074667.1, NM_001081198.1 |
UniGenei | Mm.334678 Mm.395273 |
3D structure databases
ProteinModelPortali | B2RVY9 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000110413 |
Proteomic databases
MaxQBi | B2RVY9 |
PaxDbi | B2RVY9 |
PRIDEi | B2RVY9 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENSMUST00000114765; ENSMUSP00000110413; ENSMUSG00000079588 |
GeneIDi | 381339 |
KEGGi | mmu:381339 |
UCSCi | uc007auq.1 mouse |
Organism-specific databases
CTDi | 130827 |
MGIi | MGI:1923725 Tmem182 |
Phylogenomic databases
eggNOGi | ENOG410IQ09 Eukaryota ENOG4111FRX LUCA |
GeneTreei | ENSGT00390000017581 |
HOGENOMi | HOG000043110 |
InParanoidi | B2RVY9 |
OMAi | TEVGKCS |
OrthoDBi | 1246131at2759 |
PhylomeDBi | B2RVY9 |
TreeFami | TF331344 |
Miscellaneous databases
PROi | PR:B2RVY9 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000079588 Expressed in 103 organ(s), highest expression level in quadriceps femoris |
Genevisiblei | B2RVY9 MM |
Family and domain databases
InterProi | View protein in InterPro IPR004031 PMP22/EMP/MP20/Claudin IPR026763 TMEM182 |
PANTHERi | PTHR32012 PTHR32012, 1 hit |
Pfami | View protein in Pfam PF13903 Claudin_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | TM182_MOUSE | |
Accessioni | B2RVY9Primary (citable) accession number: B2RVY9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 14, 2009 |
Last sequence update: | July 1, 2008 | |
Last modified: | January 16, 2019 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot