Tmem182

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transmembrane protein 182
Gene namesⁱ	Name:Tmem182
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:1923725 Tmem182

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	27 – 114	ExtracellularSequence analysisAdd BLAST	88
Transmembraneⁱ	115 – 135	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	136 – 153	CytoplasmicSequence analysisAdd BLAST	18
Transmembraneⁱ	154 – 174	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	175 – 200	ExtracellularSequence analysisAdd BLAST	26
Transmembraneⁱ	201 – 221	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	222 – 229	CytoplasmicSequence analysis	8

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST		26
ChainⁱPRO_0000369257	27 – 229	Transmembrane protein 182Add BLAST		203

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	47	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	68	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	85	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	102	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	B2RVY9
PaxDbⁱ	B2RVY9
PRIDEⁱ	B2RVY9

Expressionⁱ

Tissue specificityⁱ

Highly expressed in white adipose tissues (WAT), with 10-fold to 20-fold higher levels than in brown adipose tissue (BAT). Also expressed in skeletal muscle, heart and lung. Lower relative levels of expression in kidney, spleen, testis, brain and liver.1 Publication

Developmental stageⁱ

Upregulated in adipogenesis and also markedly up-regulated during in vitro myogenesis of C2C12 myoblasts to myocytes.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000079588 Expressed in 103 organ(s), highest expression level in quadriceps femoris
Genevisibleⁱ	B2RVY9 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000110413

STRINGⁱ

10090.ENSMUSP00000110413

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B2RVY9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TMEM182 family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IQ09 Eukaryota ENOG4111FRX LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017581
HOGENOMⁱ	HOG000043110
InParanoidⁱ	B2RVY9
OMAⁱ	TEVGKCS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0OD5
PhylomeDBⁱ	B2RVY9
TreeFamⁱ	TF331344

Family and domain databases

InterProⁱ	View protein in InterPro IPR004031 PMP22/EMP/MP20/Claudin IPR026763 TMEM182
PANTHERⁱ	PTHR32012 PTHR32012, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13903 Claudin_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

B2RVY9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLNVAVFFG ALFGALGVLL FLVAFGSDYW LLATEVGRCS GEQNIENITF 
        60         70         80         90        100
HHEGFFWRCW FSGVVEENNS NIWKFWYTNQ PPSKNCTHAY LSPYPFMRGE 
       110        120        130        140        150
HNSTSYDSAI IYRGFWAVLL LLGVVAALTA SFLIICAAPF SSHFLYKAGG 
       160        170        180        190        200
GSYIASGVLF SLVVILYVIW VQAVADMESY RALRMRDCWE FTPSILYGWS 
       210        220 
FFLAPAGVFF SLLAGLLFLV VGRHIQIHH

Length:229

Mass (Da):25,845

Last modified:July 1, 2008 - v1

Checksum:ⁱ35617F40902545A4

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH466536 Genomic DNA Translation: EDL14585.1 BC147440 mRNA Translation: AAI47441.1 BC147458 mRNA Translation: AAI47459.1 BC147740 mRNA Translation: AAI47741.1 BC147743 mRNA Translation: AAI47744.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35550.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001074667.1, NM_001081198.1
UniGeneⁱ	Mm.334678 Mm.395273

Genome annotation databases

Ensemblⁱ	ENSMUST00000114765; ENSMUSP00000110413; ENSMUSG00000079588
GeneIDⁱ	381339
KEGGⁱ	mmu:381339
UCSC genome browser More...UCSCⁱ	uc007auq.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
B2RVY9	Transmembrane protein 182		RAT		229	UniRef90_B2RVY9
UPI0003330FAF		JACJA		229
UPI000A30D10A		MUSPA		229
UPI000A316B74		MUSCR		229
UPI000B4E9D53		MERUN		229

Protein	Similar proteins		Species	Score	Length	Source
B2RVY9	Transmembrane protein 182		HUMAN		229	UniRef50_Q6ZP80
Transmembrane protein 182		BOVIN		229
Uncharacterized protein		RABIT		265
Uncharacterized protein		ICTTR		229
Uncharacterized protein		LOXAF		229
+208

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH466536 Genomic DNA Translation: EDL14585.1 BC147440 mRNA Translation: AAI47441.1 BC147458 mRNA Translation: AAI47459.1 BC147740 mRNA Translation: AAI47741.1 BC147743 mRNA Translation: AAI47744.1
CCDSⁱ	CCDS35550.1
RefSeqⁱ	NP_001074667.1, NM_001081198.1
UniGeneⁱ	Mm.334678 Mm.395273

3D structure databases

ProteinModelPortalⁱ	B2RVY9
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000110413

STRINGⁱ

10090.ENSMUSP00000110413

Proteomic databases

MaxQBⁱ	B2RVY9
PaxDbⁱ	B2RVY9
PRIDEⁱ	B2RVY9

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000114765; ENSMUSP00000110413; ENSMUSG00000079588
GeneIDⁱ	381339
KEGGⁱ	mmu:381339
UCSCⁱ	uc007auq.1 mouse

Organism-specific databases

CTDⁱ	130827
MGIⁱ	MGI:1923725 Tmem182

Phylogenomic databases

eggNOGⁱ	ENOG410IQ09 Eukaryota ENOG4111FRX LUCA
GeneTreeⁱ	ENSGT00390000017581
HOGENOMⁱ	HOG000043110
InParanoidⁱ	B2RVY9
OMAⁱ	TEVGKCS
OrthoDBⁱ	EOG091G0OD5
PhylomeDBⁱ	B2RVY9
TreeFamⁱ	TF331344

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:B2RVY9
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000079588 Expressed in 103 organ(s), highest expression level in quadriceps femoris
Genevisibleⁱ	B2RVY9 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR004031 PMP22/EMP/MP20/Claudin IPR026763 TMEM182
PANTHERⁱ	PTHR32012 PTHR32012, 1 hit
Pfamⁱ	View protein in Pfam PF13903 Claudin_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TM182_MOUSE
Accessionⁱ	B2RVY9Primary (citable) accession number: B2RVY9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
	Last sequence update:	July 1, 2008
	Last modified:	September 12, 2018
	This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B2RVY9 (TM182_MOUSE)

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Transmembrane protein 182

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ