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Protein

Olfactory receptor

Gene

Olfr221

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • G protein-coupled receptor activity Source: UniProtKB-KW
  • odorant binding Source: GO_Central
  • olfactory receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer
Biological processOlfactionUniRule annotationSAAS annotation, Sensory transduction

Enzyme and pathway databases

ReactomeiR-MMU-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptorUniRule annotation
Gene namesi
Name:Olfr221Imported
Synonyms:Olfr1514Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:3030055 Olfr221

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 48HelicalUniRule annotationAdd BLAST23
Transmembranei94 – 117HelicalUniRule annotationAdd BLAST24
Transmembranei123 – 145HelicalUniRule annotationAdd BLAST23
Transmembranei198 – 225HelicalUniRule annotationAdd BLAST28
Transmembranei237 – 260HelicalUniRule annotationAdd BLAST24
Transmembranei272 – 292HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell membraneUniRule annotationSAAS annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000044286 Expressed in 6 organ(s), highest expression level in testis

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063109

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 290G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST250

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410J9KZ Eukaryota
ENOG41113B2 LUCA
GeneTreeiENSGT00910000144101
HOGENOMiHOG000041364
HOVERGENiHBG017625
KOiK04257
OMAiSECYLIA
OrthoDBiEOG091G0AZH
TreeFamiTF352750

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

B2RVX8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERTNLSHEM EFELLGLTSD PQLQKLLFVV FLVMYAITVL GNLVMFFLIH
60 70 80 90 100
VSTTLHTPMY SLLKSLSLLD FCYSSTVVPQ TLLNFLVERK VISYFGCMAQ
110 120 130 140 150
MFFFAGFATS ECYLIAAMAY DRYVAVCSPL LYPTIVSPNV CASLIGGSYG
160 170 180 190 200
AGFLNSLIHT SCIFSLNFCG AHVVTHFFCD GPPILSLSCV DTSLCEILLF
210 220 230 240 250
IFAGFNLLSC TLTILISYLL IFIAILQMRS NQGRFKAFST CSSHLTAVCF
260 270 280 290 300
FFGTTLFMYL RPKSSYSLTQ DRTVAVIYTA VIPMLNPLIY SLRNKDVKEA
310
LRRVWGWKAM G
Length:311
Mass (Da):34,847
Last modified:July 1, 2008 - v1
Checksum:i37C2B043DE7869A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157572 Genomic DNA No translation available.
BC147427 mRNA Translation: AAI47428.1
BC147428 mRNA Translation: AAI47429.1
BC151091 mRNA Translation: AAI51092.1
BC151095 mRNA Translation: AAI51096.1
RefSeqiNP_001001808.2, NM_001001808.2
UniGeneiMm.377946

Genome annotation databases

EnsembliENSMUST00000052560; ENSMUSP00000063109; ENSMUSG00000044286
ENSMUST00000214071; ENSMUSP00000150675; ENSMUSG00000044286
ENSMUST00000214342; ENSMUSP00000150231; ENSMUSG00000044286
ENSMUST00000216188; ENSMUSP00000149854; ENSMUSG00000044286
ENSMUST00000216907; ENSMUSP00000151163; ENSMUSG00000044286
GeneIDi258420
KEGGimmu:258420
UCSCiuc007toa.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC157572 Genomic DNA No translation available.
BC147427 mRNA Translation: AAI47428.1
BC147428 mRNA Translation: AAI47429.1
BC151091 mRNA Translation: AAI51092.1
BC151095 mRNA Translation: AAI51096.1
RefSeqiNP_001001808.2, NM_001001808.2
UniGeneiMm.377946

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063109

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052560; ENSMUSP00000063109; ENSMUSG00000044286
ENSMUST00000214071; ENSMUSP00000150675; ENSMUSG00000044286
ENSMUST00000214342; ENSMUSP00000150231; ENSMUSG00000044286
ENSMUST00000216188; ENSMUSP00000149854; ENSMUSG00000044286
ENSMUST00000216907; ENSMUSP00000151163; ENSMUSG00000044286
GeneIDi258420
KEGGimmu:258420
UCSCiuc007toa.1 mouse

Organism-specific databases

CTDi258420
MGIiMGI:3030055 Olfr221

Phylogenomic databases

eggNOGiENOG410J9KZ Eukaryota
ENOG41113B2 LUCA
GeneTreeiENSGT00910000144101
HOGENOMiHOG000041364
HOVERGENiHBG017625
KOiK04257
OMAiSECYLIA
OrthoDBiEOG091G0AZH
TreeFamiTF352750

Enzyme and pathway databases

ReactomeiR-MMU-381753 Olfactory Signaling Pathway

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044286 Expressed in 6 organ(s), highest expression level in testis

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB2RVX8_MOUSE
AccessioniPrimary (citable) accession number: B2RVX8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 2008
Last sequence update: July 1, 2008
Last modified: November 7, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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